Hepatitis B Virus and Carcinogenesis—Pathophysiology, Disease and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 36634
Special Issue Editor
Interests: viral hepatitis; viral carcinogenesis; liver cancer; HBV molecular variants and integration; biomarkers; clinical and translational researches in liver diseases
Special Issue Information
Dear Colleagues,
Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). Despite advances in anti-HBV therapies, there is still no cure for HBV. Current antiviral drugs improve overall patient outcomes through the effective suppression of viral replication, but they do not eradicate HBV, particularly the cccDNA, which often causes viral reactivation as well as liver disease progression after cessation of treatment. HCC still occurs in a subset of patients on therapy, even with maintained HBV remission. HBV can drive liver carcinogenesis through direct oncogenic potential such as HBV integration or viral oncoproteins (HBx and LHBs) from intrahepatic cccDNA, which cannot be targeted by current antiviral therapy. In addition, other direct or indirect viral factors can induce HCC, including HBV genotypes, molecular variants (pre-S deletion, mutations in the HBx/precore regions), and viral antigens (HBsAg, HBcrAg, and HBx).
This Special Issue “Hepatitis B Virus and Carcinogenesis—Pathophysiology, Disease and Treatment” of the International Journal of Molecular Sciences aims at providing an updated overview of basic, translational, and clinical knowledge on the virology, pathophysiology, immunology, and molecular genomics of HBV and HBV-associated HCC as well as on the development of innovative diagnostic and therapeutic approaches, while debating their promises and pitfalls.
Prof. Dr. Jeong-Won Jang
Guest Editor
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Keywords
- direct oncogenic potential of HBV
- HBV molecular variants
- liver inflammation and immunology
- intrahepatic cccDNA
- HBx/HBs oncoproteins
- HBV integration
- genomics of HBV and liver cancer
- targeting for the cure of HBV
- biomarkers of HBV
- Basic-clinical translational research in HBV
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