Hidradenitis Suppurativa and Related Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 24984
Special Issue Editors
Interests: chronic inflammatory skin diseases; epithelia-targeting cytokines; cytokine networks; epidermal immune defense; skin barrier; epigenetic memory of the inflamed skin
Interests: chronic inflammatory skin diseases; link between local inflammation and systemic comorbidity; novel cytokines; T cell subpopulations; transplantation immunology; innovative treatments for chronic inflammation; biomarkers; biologics
Interests: chronic inflammatory skin diseases; autoimmunity; sex bias; stromal-immune interactions; keratinocytes; fibroblasts; bioinformatics; single-cell and spatial-seq technologies
Special Issue Information
Dear Colleagues,
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting ~1% of the Western population. HS manifests with painful, deep-seated inflamed nodules, abscesses and pus-draining epithelialized tunnels that develop primarily in axillary, inguinal, gluteal and perianal body areas (1). In addition, patients often suffer from systemic comorbidities, such as metabolic syndrome, arteriosclerosis and spondyloarthritis. HS not only profoundly impairs affected individuals’ private and professional lives but also reduces their life expectancy. The pathomechanisms underlying the skin inflammation in HS are only partially understood. Skin lesions are known to harbor highly activated immune cells, including neutrophils, macrophages, T cells and B cells. As the disease progresses, these cells provoke pus formation and local destruction of the physiological skin architecture. IL-1, TNF-α, IL-17 and G-CSF apper to play important roles in these processes. Interestingly, some similar molecular pathomechanisms have been found in other chronic skin diseases, such as folliculitis decalvans (FD), pyoderma gangrenosum (PG), acne conglobate (AC), palmoplantar pustulosis (PPP) and pityriasis rubra pilaris (PRP).
The paucity of knowledge about the pathogenesis of HS, FD, PG, AC, PPP or PRP is largely responsible for the currently very limited treatment options for these diseases. This Special Issue aims to provide a platform for dedicated scientists to publish recent discoveries on the pathogenesis of HS and related skin disorders, thereby advancing our understanding of the molecular mechanisms of these diseases and stimulating the development of innovative, targeted therapeutics.
Topics of interest for this Special Issue include, but are not limited to:
- Molecular mechanisms through which lifestyle factors drive the onset of the diseases;
- Molecular and immunological pathomechanisms underling skin inflammation;
- Role of innate immune receptors (PRPs);
- Crosstalk between tissue and immune cells in the inflamed skin;
- Mediators of the dysfunction of keratinocytes, fibroblasts, or endothelial cells;
- Molecular markers of immune cell heterogeneity;
- Elements linking cutaneous inflammation to systemic commodities;
- Potential novel therapeutic targets for the treatment of the diseases;
- Molecular or immunological biomarkers for the severity or progressive course of the diseases.
(1) Hidradenitis suppurativa. Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K. Nat Rev Dis Primers. 2020 Mar 12;6(1):18.
Dr. Kerstin Wolk
Dr. Robert Sabat
Prof. Dr. Johann Gudjonsson
Guest Editors
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Keywords
- hidradenitis suppurativa
- acne inversa
- palmoplantar pustulosis
- pyoderma gangrenosum
- inflammation
- cytokines
- IL-1
- IL-17
- TNF
- G-CSF
- inflammasome
- intercellular communication
- T cells
- B cells
- plasma cells
- neutrophilic granulocytes
- omics
- therapeutic targets
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