Molecular Pathology and Immunotherapy of Lymphoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 5461
Special Issue Editor
Special Issue Information
Dear Colleagues,
Lymphomas are a large group of malignancies involving lymphoid tissues, and are divided into two large subgroups: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphomas (NHL). CAR-T therapy and immune checkpoint inhibitors have been introduced in the clinical practice of malignant lymphomas. On the other hand, there are many histopathological subtypes that cannot directly receive the benefits of immunotherapy, and sufficient improvement in the prognosis of these subtypes is not observed.
Over the past decade, advances in high-throughput sequencing technologies have provided a wealth of information on the role of both genomic and epigenomic deregulations in the malignant transformation and pathophysiology of B- and T-lymphoid malignancies. A broad range of genetic alterations are now incorporated into World Health Organization-defined criteria for the diagnostic evaluation of patients with lymphoid malignancies. Future advances in molecular methods will enable the expansion of the knowledge of lymphomagenesis by increasing the variety of tools used in daily clinical practice, including diagnosis, risk stratification, identification of therapeutic targets, treatment resistance, and the determination of minimal measures of residual disease in lymphomas. By carrying this out, each patient will be provided with more effective treatments with fewer side effects and with the ultimate goal of prolonging survival and/or curing the disease.
Dr. Monica Civallero
Guest Editor
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Keywords
- lymphoma diagnostics
- immunotherapy
- molecular diagnostics
- non-Hodgkin lymphoma
- sequencing
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