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Recent Research on Hypertension and Related Complications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 4375

Special Issue Editor


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Guest Editor
Department of Internal Medicine, Nephrology Division, Ghent University Hospital, 9000 Ghent, Belgium
Interests: biochemistry; biomarkers; hypertension; cardiovascular disease; kidney disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hypertension remains the most common cardiovascular illness and a major public health concern worldwide. It is a significant risk factor for a variety of serious consequences, including myocardial infarction, cerebrovascular accidents and chronic kidney disease. Despite significant advances in medical study, the precise pathophysiological pathways driving hypertension and its complications are not fully understood. In order to gain a better understanding of the causes, treatment methods and preventive measures for hypertension, it is important to continue conducting research. This highlights the importance of having a dedicated platform where new scientific discoveries on this critical topic can be shared.

The main objective of this Special Issue is to gather the most recent research on hypertension and its associated issues, which are known for their complex nature. We invite papers that explore innovative diagnostic techniques, effective therapeutic strategies and preventive measures. Furthermore, we are quite supportive of studies that investigate the biochemical, environmental and genetic components of hypertension. We also promote research on novel strategies for management and intervention. This Special Issue will include review articles, original research papers and case reports to provide a comprehensive picture of recent advances in hypertension research. This Special Issue aims to expand our understanding of hypertension and contribute to the development of effective measures to reduce its impact on global health through collaboration among various scientific views.

Prof. Dr. Marijn Speeckaert
Guest Editor

Manuscript Submission Information

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Keywords

  • arterial hypertension
  • cardiovascular disease
  • pathophysiology
  • molecular mechanisms
  • complications

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Published Papers (2 papers)

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Review

18 pages, 1049 KiB  
Review
Hypertension: A Continuing Public Healthcare Issue
by Samaneh Goorani, Somaye Zangene and John D. Imig
Int. J. Mol. Sci. 2025, 26(1), 123; https://doi.org/10.3390/ijms26010123 - 26 Dec 2024
Cited by 1 | Viewed by 2318
Abstract
Hypertension is a cardiovascular disease defined by an elevated systemic blood pressure. This devastating disease afflicts 30–40% of the adult population worldwide. The disease burden for hypertension is great, and it greatly increases the risk of cardiovascular morbidity and mortality. Unfortunately, there are [...] Read more.
Hypertension is a cardiovascular disease defined by an elevated systemic blood pressure. This devastating disease afflicts 30–40% of the adult population worldwide. The disease burden for hypertension is great, and it greatly increases the risk of cardiovascular morbidity and mortality. Unfortunately, there are a myriad of factors that result in an elevated blood pressure. These include genetic factors, a sedentary lifestyle, obesity, salt intake, aging, and stress. Although lifestyle modifications have had limited success, anti-hypertensive drugs have been moderately effective in lowering blood pressure. New approaches to control and treat hypertension include digital health tools and compounds that activate the angiotensin receptor type 2 (AT2), which can promote cardiovascular health. Nonetheless, research on hypertension and its management is vital for lessening the significant health and economic burden of this condition. Full article
(This article belongs to the Special Issue Recent Research on Hypertension and Related Complications)
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17 pages, 1311 KiB  
Review
An Overview on Renal and Central Regulation of Blood Pressure by Neuropeptide FF and Its Receptors
by Hewang Lee, Jun B. Feranil and Pedro A. Jose
Int. J. Mol. Sci. 2024, 25(24), 13284; https://doi.org/10.3390/ijms252413284 - 11 Dec 2024
Viewed by 1407
Abstract
Neuropeptide FF (NPFF) is an endogenous octapeptide that was originally isolated from the bovine brain. It belongs to the RFamide family of peptides that has a wide range of physiological functions and pathophysiological effects. NPFF and its receptors, NPFFR1 and NPFFR2, abundantly expressed [...] Read more.
Neuropeptide FF (NPFF) is an endogenous octapeptide that was originally isolated from the bovine brain. It belongs to the RFamide family of peptides that has a wide range of physiological functions and pathophysiological effects. NPFF and its receptors, NPFFR1 and NPFFR2, abundantly expressed in rodent and human brains, participate in cardiovascular regulation. However, the expressions of NPFF and its receptors are not restricted within the central nervous system but are also found in peripheral organs, including the kidneys. Both NPFFR1 and NPFFR2 mainly couple to Gαi/o, which inhibits cyclic adenosine monophosphate (cAMP) production. NPFF also weakly binds to other RFamide receptors and the Mas receptor. Relevant published articles were searched in PubMed, Google Scholar, Web of Science, and Scopus. Herein, we review evidence for the role of NPFF in the regulation of blood pressure, in the central nervous system, particularly within the hypothalamic paraventricular nucleus and the brainstem, and the kidneys. NPFF is a potential target in the treatment of hypertension. Full article
(This article belongs to the Special Issue Recent Research on Hypertension and Related Complications)
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