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Advance Research about Ocular Surface in Ophthalmology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4514

Special Issue Editor


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Guest Editor
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Interests: ophthalmology; inflammation and regenerative medicine

Special Issue Information

Dear Colleagues,

In recent years, several novel treatment options have been investigated for the treatment of ocular surface diseases. This Special Issue titled “Advance Research about Ocular Surface in Ophthalmology” will focus on recent molecular research in the field of the ocular surface in ophthalmology. However, although promising clinical outcomes have been revealed in real-life studies by the current agents available for treating these diseases, there is still a need for improving the long-term clinical efficacy, by simultaneously decreasing the treatment burden and patients’ compliance. We welcome publications on new findings concerning the pathogenesis, genetic analysis, diagnostics, and therapy of ocular surface diseases, such as Stevens–Johnson syndrome, ocular cicatricial pemphigoid, and dry eye syndrome, as well as all the involved molecular pathways.

Hence, this Special Issue aims to collect papers focusing on the molecular mechanisms of the latest developments in treatment options for the management of ocular diseases. Data on molecular mechanisms or pathophysiology are essential, and papers that only contain clinical trials/data are not acceptable. We invite contributions including reviews and/or original papers that report new results about biological ocular rehabilitation.

Dr. Mayumi Ueta
Guest Editor

Manuscript Submission Information

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Keywords

  • Stevens-Johnson syndrome
  • ocular cicatricial pemphigoid
  • dry eye syndrome
  • stye
  • uveitis
  • keratitis
  • ophthalmology

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Published Papers (1 paper)

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Review

42 pages, 3395 KiB  
Review
Animal Models in Eye Research: Focus on Corneal Pathologies
by Alexis Loiseau, Gabrielle Raîche-Marcoux, Cloé Maranda, Nicolas Bertrand and Elodie Boisselier
Int. J. Mol. Sci. 2023, 24(23), 16661; https://doi.org/10.3390/ijms242316661 - 23 Nov 2023
Cited by 6 | Viewed by 4062
Abstract
The eye is a complex sensory organ that enables visual perception of the world. The dysfunction of any of these tissues can impair vision. Conduction studies on laboratory animals are essential to ensure the safety of therapeutic products directly applied or injected into [...] Read more.
The eye is a complex sensory organ that enables visual perception of the world. The dysfunction of any of these tissues can impair vision. Conduction studies on laboratory animals are essential to ensure the safety of therapeutic products directly applied or injected into the eye to treat ocular diseases before eventually proceeding to clinical trials. Among these tissues, the cornea has unique homeostatic and regenerative mechanisms for maintaining transparency and refraction of external light, which are essential for vision. However, being the outermost tissue of the eye and directly exposed to the external environment, the cornea is particularly susceptible to injury and diseases. This review highlights the evidence for selecting appropriate animals to better understand and treat corneal diseases, which rank as the fifth leading cause of blindness worldwide. The development of reliable and human-relevant animal models is, therefore, a valuable research tool for understanding and translating fundamental mechanistic findings, as well as for assessing therapeutic potential in humans. First, this review emphasizes the unique characteristics of animal models used in ocular research. Subsequently, it discusses current animal models associated with human corneal pathologies, their utility in understanding ocular disease mechanisms, and their role as translational models for patients. Full article
(This article belongs to the Special Issue Advance Research about Ocular Surface in Ophthalmology)
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