MicroRNAs and Stem Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 40968
Special Issue Editor
Interests: stem cells; cell senescence; stem cell differentiation; adipogenesis; osteogenesis; cardiogenesis; conditioned media; nutraceuticals; gene expression; epigenetics; cellular mechanisms; cell-based therapies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
MicroRNAs are involved in cellular processes such as differentiation, growth, and apoptosis. Stem cells have peculiar properties such as differentiation and self-renewal, which can be strongly influenced by epigenetic changes. In particular, miRNAs are able to fine-tune stem cell behavior by suppressing the translation of many target mRNAs, thus inducing fluctuations in gene expression and protein translation. In particular, two large miRNA families (i.e., the miR-200 and the miR-302 families) are pluripotent activators able to modulate pluripotent genes. These two miRNA families can be down-regulated by the activation of TGF-β, itself being directly modulated by both miR-200 and miR-302 and consequently involved in cell differentiation and reprogramming. Unraveling epigenetic factors and their role in influencing pluripotency and stem cell differentiation capabilities could pave the way for new therapeutic approaches in regenerative medicine. The Special Issue, “MicroRNAs and Stem cells” of the International Journal of Molecular Sciences will include a selection of research papers and reviews about various aspects of the molecular regulation of stem cell behavior and cellular phenotype by miRNA. In addition, clinical studies evaluating miRNA and stem cells in regenerative medicine are suitable.
Assoc. Prof. Margherita Maioli
Guest Editor
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Keywords
- miRNA
- Epigenetic
- Stem cells
- Pluripotency
- Stem cell differentiation
- Gene expression
- New therapeutic targets
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