Molecular and Therapeutic Research in Rheumatoid Arthritis, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 October 2024 | Viewed by 755
Special Issue Editor
Interests: rheumatoid arthritis; cardiovascular risk; microRNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects approximately 1% of the world’s population. It is characterized by inflammation and damage of the joints, which causes pain, stiffness, and a loss of general function. Over the last few decades, researchers have made great advances in understanding the mechanisms behind this condition and how can they be targeted to treat it. However, the exact etiology of this disease is not yet fully understood.
RA is a complex disease that involves a multitude of factors, such as environmental, genetic, and epigenetic factors. Additionally, molecular research has revealed multiple molecular factors that contribute to this disease’s pathogenesis, including a variety of immune cells, such as T-cells, B-cells, macrophages, and neutrophils, and has provided better molecular insights into the various cytokines and chemokines involved in the immune response. Targeting these cytokines with biologic drugs has revolutionized RA treatment, but researchers continue to search for new drug targets to address the underlying immune dysfunction. New research has also shown promise in identifying other molecular targets for RA therapy, including molecules that impact the activation and differentiation of immune cells, enzymes that regulate cellular signaling pathways, as well as small non-coding RNAs and microRNAs that can regulate gene expression in the RA pathogenesis process. Overall, these molecular advances in RA research hold promise for more precise and personalized treatment approaches, allowing for earlier intervention and improved patient outcomes.
This Special Issue aims to showcase the recent advances in research related to RA, with the aim of identifying novel effective molecular targets for the development of preventive and therapeutic strategies. We encourage investigators to submit original research focused on the molecular mechanisms underlying the development, progression, or treatment of RA. Manuscripts should focus on cutting-edge research to provide new insights into the physiological and pathophysiological processes involved in the development and progression of rheumatoid arthritis. The scope of this Special Issue includes experimental medical approaches and human studies that provide opportunities for “back translation” into basic research. We welcome proposals aimed at improving our understanding of the molecular mechanisms underlying RA at the cellular, systemic, and whole-body levels in humans or model systems. Clinical papers that focus on the molecular pathways or intermediates involved in the development and progression of rheumatoid arthritis are also welcome in this Special Issue, and manuscripts that examine the relationship between clinical outcomes and molecular targets, biomarkers, or pathways are particularly welcome. Additionally, review articles that critically and systematically cover related research, with concluding remarks and an outlook, will be considered for inclusion in this Special Issue.
This Special Issue is a continuation of our previous Special Issue, “Molecular and Therapeutic Research in Rheumatoid Arthritis”.
Dr. Joan Carles Vallvé
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- rheumatoid arthritis
- inflammation
- cytokines
- autoimmunity
- microRNAs
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