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Molecular Research on the Gut Microbiota in Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 462

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Guest Editor
Anaesthesia and Intensive Care Assistant Medical Director (EMS-PA) Researcher, Pneumology and Respiratory Rehabilitation Unit, Clinical Scientific Institutes Maugeri (ICS), Research Hospitals of National Interest (IRCCS), Section of Bari, Pavia, Italy
Interests: anesthesia and intensive care; human microbiota; metabolomics; respiratory diseases; mechanical ventilation; respiratory emergencies/urgencies; xenobiotic poisoning; history and ethics of medicine
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Special Issue Information

Dear Colleagues,

In recent years, the scientific community has been increasingly interested in studying the multitude of microbes found in our bodies and how they affect human health. Traditionally, this population of microbes, which normally grows in certain sites (such as the gut, respiratory tract, and blood) of the body, is referred to as microbiota, while the term microbiome is currently used and also refers to the genotypes of these microbes which, thanks to the progress of molecular biology, can now be decoded. There is a great variety of genera of microorganisms found in the human body, and they characterize each person. They contribute directly or indirectly to processes such as immune reactions, the regulation of certain neurotransmitters and hormones, and the production of antioxidant molecules. Studies also support their antibiotic, anti-inflammatory, antidiabetic, and anticancer roles. They can even affect systemic diseases (coronary heart disease, irritable bowel syndrome, diabetes mellitus) and infectious diseases. The gut microbiota is considered an “organ” of our body mainly because of the interaction of microorganisms with the host. Thus, there is crosstalk between axes of the microbiota such as gut/lung and gut/brain. When diversity is lost, homeostasis is disturbed, sometimes with other consequences—a condition called dysbiosis—which can lead to certain disorders and diseases.

The purpose of this Special Issue is to invite submissions of research articles to present modern data and the most relevant research on the correlation of the microbiota with the onset, progression, and treatment of related diseases.

We look forward to receiving your submission.

Dr. Ioannis Alexandros Charitos
Guest Editor

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Keywords

  • gut microbiota
  • molecular research
  • dysbiosis

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Published Papers (1 paper)

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27 pages, 1311 KiB  
Review
Intestinal Microbiota Dysbiosis Role and Bacterial Translocation as a Factor for Septic Risk
by Ioannis Alexandros Charitos, Salvatore Scacco, Antonella Cotoia, Francesca Castellaneta, Giorgio Castellana, Federico Pasqualotto, Maria Venneri, Angela Ferrulli, Maria Aliani, Luigi Santacroce and Mauro Carone
Int. J. Mol. Sci. 2025, 26(5), 2028; https://doi.org/10.3390/ijms26052028 - 26 Feb 2025
Viewed by 102
Abstract
The human immune system is closely linked to microbiota such as a complex symbiotic relationship during the coevolution of vertebrates and microorganisms. The transfer of microorganisms from the mother’s microbiota to the newborn begins before birth during gestation and is considered the initial [...] Read more.
The human immune system is closely linked to microbiota such as a complex symbiotic relationship during the coevolution of vertebrates and microorganisms. The transfer of microorganisms from the mother’s microbiota to the newborn begins before birth during gestation and is considered the initial phase of the intestinal microbiota (IM). The gut is an important site where microorganisms can establish colonies. The IM contains polymicrobial communities, which show complex interactions with diet and host immunity. The tendency towards dysbiosis of the intestinal microbiota is influenced by local but also extra-intestinal factors such as inflammatory processes, infections, or a septic state that can aggravate it. Pathogens could trigger an immune response, such as proinflammatory responses. In addition, changes in the host immune system also influence the intestinal community and structure with additional translocation of pathogenic and non-pathogenic bacteria. Finally, local intestinal inflammation has been found to be an important factor in the growth of pathogenic microorganisms, particularly in its role in sepsis. The aim of this article is to be able to detect the current knowledge of the mechanisms that can lead to dysbiosis of the intestinal microbiota and that can cause bacterial translocation with a risk of infection or septic state and vice versa. Full article
(This article belongs to the Special Issue Molecular Research on the Gut Microbiota in Diseases)
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