Molecular Advances in Glomerular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 9511
Special Issue Editors
Interests: glomerulonephritis; nephrotic syndrome genetics and mechanisms; therapy of nephrotic syndrome; systemic lupus erythematosus; lupus nephritis; mechanisms for autoimmunity
Interests: autoimmunity clinical trials rheumatic diseases; cell adhesion renal rheumatoid arthritis; autoimmune disease autoantibodies clinical immunology
Special Issue Information
Dear Colleagues,
Glomerular diseases are a heterogeneous group of inflammatory diseases that represent an important cause of chronic morbidity, potentially evolving to renal failure. Pathology features, specific mechanisms causing glomerular damage, and association with extra-renal conditions represent the basis for a general classification that has clinical implications. Renal pathology varies from minimal lesions to diffuse glomerular proliferation, thickening of the basement membrane, and alteration of the microvasculature; circulating autoantibodies versus intrinsic or implanted antigens are often involved as a starting mechanism, and deposition of elements of the complement cascade may be involved as a main pathogenetic feature. Variable degrees of proteinuria, including nephrotic syndrome and hematuria, are the classical hallmarks that aggregate different conditions.
Evolutions in the pathogenesis of 'glomerular diseases' are sound and include the recognition of new autoantibodies causative of primary and secondary forms (Membranous nephropathy, Lupus nephritis), regulatory cells involved in inflammation, and other mechanisms of direct damage. Therapies do not witness those evolutions and have been substantially based, for many years, on the same drugs (steroids, CNI, mycophenolate mofetyl, anti-CD20).
Recognizing molecular factors would help us to implement potential targets of therapeutics, which is of particular interest in an era in which many new drugs targeting specific actors of inflammation, such as T/B cells, interleukins, intracellular factors, etc., have been developed and are already utilized with success in other inflammatory conditions.
Dr. Gian Marco Ghiggeri
Dr. Renato Alberto Sinico
Dr. Andrea Angeletti
Guest Editors
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Keywords
- glomerulonephritis
- proteinuria
- autoantibodies
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