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Serotonin in Health and Diseases
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Serotonin in Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3360

Special Issue Editor

Dr. Elena E. Voronezhskaya

E-Mail Website
Guest Editor
Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow 119334, Russia
Interests: development; neurogenesis; ciliogenesis; serotonylation; invertebrates

Special Issue Information

Dear Colleagues,

What do you imagine when you hear the word "serotonin"? Probably the brain, neurons, mammalian behavior, and migraines. However, serotonin is much more! This biogenic amine (5-hydroxytryptamine, 5- HT) is an ancient substance with a wide variety of functions. It is found in almost all representatives of the animal kingdom, appears in development as early as the single-cell stage, and accompanies the life of the organism until its last days. Normally, serotonin exerts its physiological effects through the activation of more than 14 different receptors on the cell membrane. In addition, it has recently been found that 5-HT as an intracellular agent causes posttranslational protein modification—serotonylation—and is thus involved in important physiological and pathophysiological processes, including permissive gene expression.

In this Special Issue, we would like to encourage all researchers whose work is related to serotonin to present their latest findings, in-depth expertise, and methodological benefits to the wide audience of IJMS. The issue will cover a broad area of serotonin as a biological substance, from distribution to functions, in the course of development, growth, and aging. Any subtleties of serotonin action in health and disease that you have uncovered using model systems in vertebrates and invertebrates are welcome!

Dr. Elena E. Voronezhskaya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • components of serotonergic system
  • serotonin targets
  • related systems
  • serotonergic mechanisms
  • experimental models

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Published Papers (2 papers)

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Research

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10 pages, 1811 KiB  
Communication
Serotonin Transporter Activity in Mouse Oocytes Is a Positive Indicator of Follicular Growth and Oocyte Maturity
by Nina M. Alyoshina, Maria D. Tkachenko, Yulia O. Nikishina and Denis A. Nikishin
Int. J. Mol. Sci. 2023, 24(14), 11247; https://doi.org/10.3390/ijms241411247 - 8 Jul 2023
Viewed by 1807
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) is known to be a regulator of oocyte maturation in a large number of animal species. In maturing mammalian oocytes, the accumulation of exogenous, maternal serotonin occurs due to the activity of the membrane transporter SERT. In this work, we [...] Read more.
Serotonin (5-hydroxytryptamine, 5-HT) is known to be a regulator of oocyte maturation in a large number of animal species. In maturing mammalian oocytes, the accumulation of exogenous, maternal serotonin occurs due to the activity of the membrane transporter SERT. In this work, we investigated how SERT activity in oocytes correlates with indicators of follicular selection and oocyte maturity. An immunohistochemical study showed that the difference in the 5-HT intake activity in oocytes does not correlate with the marker of apoptosis in follicular cells, but positively correlates with markers of follicular growth, such as granulosa proliferation and follicle size. Functional analysis of oocytes at different stages of maturation showed that the expression and activity of SERT increases with oocyte maturation. An in vivo experiment on administration of the selective serotonin reuptake inhibitor fluoxetine (20 mg/kg) for 7 days showed a significant decrease in the content of serotonin in both growing GV-oocytes and ovulated mature MII-oocytes. The data obtained clearly indicate that the mechanism of specific membrane transport of serotonin normally ensures the accumulation of serotonin in maturing oocytes, and can be considered as a promising positive marker of their mature status. Full article
(This article belongs to the Special Issue Serotonin in Health and Diseases)
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Review

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15 pages, 699 KiB  
Review
The Serotonin 4 Receptor Subtype: A Target of Particular Interest, Especially for Brain Disorders
by Véronique Sgambato
Int. J. Mol. Sci. 2024, 25(10), 5245; https://doi.org/10.3390/ijms25105245 - 11 May 2024
Viewed by 778
Abstract
In recent years, particular attention has been paid to the serotonin 4 receptor, which is well expressed in the brain, but also peripherally in various organs. The cerebral distribution of this receptor is well conserved across species, with high densities in the basal [...] Read more.
In recent years, particular attention has been paid to the serotonin 4 receptor, which is well expressed in the brain, but also peripherally in various organs. The cerebral distribution of this receptor is well conserved across species, with high densities in the basal ganglia, where they are expressed by GABAergic neurons. The 5-HT4 receptor is also present in the cerebral cortex, hippocampus, and amygdala, where they are carried by glutamatergic or cholinergic neurons. Outside the central nervous system, the 5-HT4 receptor is notably expressed in the gastrointestinal tract. The wide distribution of the 5-HT4 receptor undoubtedly contributes to its involvement in a plethora of functions. In addition, the modulation of this receptor influences the release of serotonin, but also the release of other neurotransmitters such as acetylcholine and dopamine. This is a considerable asset, as the modulation of the 5-HT4 receptor can therefore play a direct or indirect beneficial role in various disorders. One of the main advantages of this receptor is that it mediates a much faster antidepressant and anxiolytic action than classical selective serotonin reuptake inhibitors. Another major benefit of the 5-HT4 receptor is that its activation enhances cognitive performance, probably via the release of acetylcholine. The expression of the 5-HT4 receptor is also altered in various eating disorders, and its activation by the 5-HT4 agonist negatively regulates food intake. Additionally, although the cerebral expression of this receptor is modified in certain movement-related disorders, it is still yet to be determined whether this receptor plays a key role in their pathophysiology. Finally, there is no longer any need to demonstrate the value of 5-HT4 receptor agonists in the pharmacological management of gastrointestinal disorders. Full article
(This article belongs to the Special Issue Serotonin in Health and Diseases)
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