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Ion Channels in the Nervous System
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Ion Channels in the Nervous System

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 4977

Special Issue Editor

Dr. Hana Zemkova

E-Mail Website
Guest Editor
Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic
Interests: release of neurotransmitters and hormones; ion channels; P2X receptors; molecular structure
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ion channels are fundamentally involved in most neuronal functions, and their abnormal functioning plays a role in a number of disorders and diseased states often accompanied by neurodegeneration in the central and peripheral nervous systems. Understanding the processes regulating the trafficking and functioning of ion channels in the brain is crucial for developing new therapeutic strategies for the wide variety of channelopathies and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, as well as for neuropathic pain states that manifest neuronal damage. In this Special Issue, original studies or review articles on all aspects of trafficking and functioning of voltage-gated and ligand-gated ion channels (Na+, K+, Ca2+, and Cl- channels, and ionotrophic glutamate- and GABA-gated and purinergic P2X receptor channels, for example) expressed in neurons and glia cells are welcome. In particular, molecular analyses of their structure and function, ion selectivity, localization, physiology, and pharmacology, as well as the impact of novel screening technologies on understanding neuronal activity in vivo, are favorable. It will also cover the reports providing new insights into modeling the diversity of spontaneous and agonist-induced patterns of action potentials.

Dr. Hana Zemkova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • voltage-gated ion channels
  • ligand-gated ion channels
  • neurons
  • glia cells
  • electrical activity
  • molecular structure
  • molecular pathway

Published Papers (3 papers)

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Research

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15 pages, 4881 KiB  
Article
Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model
by Hsien-Yin Liao, Chia-Ming Yen, I-Han Hsiao, Hsin-Cheng Hsu and Yi-Wen Lin
Int. J. Mol. Sci. 2024, 25(5), 2901; https://doi.org/10.3390/ijms25052901 - 1 Mar 2024
Viewed by 998
Abstract
Pain is an unpleasant sensory and emotional experience accompanied by tissue injury. Often, an individual’s experience can be influenced by different physiological, psychological, and social factors. Fibromyalgia, one of the most difficult-to-treat types of pain, is characterized by general muscle pain accompanied by [...] Read more.
Pain is an unpleasant sensory and emotional experience accompanied by tissue injury. Often, an individual’s experience can be influenced by different physiological, psychological, and social factors. Fibromyalgia, one of the most difficult-to-treat types of pain, is characterized by general muscle pain accompanied by obesity, fatigue, sleep, and memory and psychological concerns. Fibromyalgia increases nociceptive sensations via central sensitization in the brain and spinal cord level. We used intermittent cold stress to create a mouse fibromyalgia pain model via a von Frey test (day 0: 3.69 ± 0.14 g; day 5: 2.13 ± 0.12 g). Mechanical pain could be reversed by eicosapentaenoic acid (EPA) administration (day 0: 3.72 ± 0.14 g; day 5: 3.69 ± 0.13 g). A similar trend could also be observed for thermal hyperalgesia. The levels of elements in the transient receptor potential V1 (TRPV1) signaling pathway were increased in the ascending pain pathway, including the thalamus, medial prefrontal cortex, somatosensory cortex, anterior cingulate cortex, and cerebellum. EPA intake significantly attenuated this overexpression. A novel chemogenetics method was used to inhibit SSC and ACC activities, which presented an analgesic effect through the TRPV1 downstream pathway. The present results provide insights into the role of the TRPV1 signaling pathway for fibromyalgia and its potential as a clinical target. Full article
(This article belongs to the Special Issue Ion Channels in the Nervous System)
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Review

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22 pages, 880 KiB  
Review
Pathological Functions of Lysosomal Ion Channels in the Central Nervous System
by Jianke Cen, Nan Hu, Jiawen Shen, Yongjing Gao and Huanjun Lu
Int. J. Mol. Sci. 2024, 25(12), 6565; https://doi.org/10.3390/ijms25126565 - 14 Jun 2024
Viewed by 878
Abstract
Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl−, Na+, [...] Read more.
Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl−, Na+, H+, and K+ across lysosomal membranes in response to osmotic stimulus, nutrient-dependent signals, and cellular stresses. These ion channels serve as the crucial transducers of cell signals and are essential for the regulation of lysosomal biogenesis, motility, membrane contact site formation, and lysosomal homeostasis. In terms of pathophysiology, genetic variations in these channel genes have been associated with the development of lysosomal storage diseases, neurodegenerative diseases, inflammation, and cancer. This review aims to discuss the current understanding of the role of these ion channels in the central nervous system and to assess their potential as drug targets. Full article
(This article belongs to the Special Issue Ion Channels in the Nervous System)
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20 pages, 3410 KiB  
Review
Ion Channel Disturbances in Migraine Headache: Exploring the Potential Role of the Kynurenine System in the Context of the Trigeminovascular System
by Eleonóra Spekker, Gábor Nagy-Grócz and László Vécsei
Int. J. Mol. Sci. 2023, 24(23), 16574; https://doi.org/10.3390/ijms242316574 - 21 Nov 2023
Cited by 4 | Viewed by 2651
Abstract
Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. [...] Read more.
Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. In recent decades, it has been suggested that ion channels may be important participants in the pathogenesis of migraine. Numerous ion channels are expressed in the peripheral and central nervous systems, including the trigeminovascular system, affecting neuron excitability, synaptic energy homeostasis, inflammatory signaling, and pain sensation. Dysfunction of ion channels could result in neuronal excitability and peripheral or central sensitization. This narrative review covers the current understanding of the biological mechanisms leading to activation and sensitization of the trigeminovascular pain pathway, with a focus on recent findings on ion channel activation and modulation. Furthermore, we focus on the kynurenine pathway since this system contains kynurenic acid, which is an endogenous glutamate receptor antagonist substance, and it has a role in migraine pathophysiology. Full article
(This article belongs to the Special Issue Ion Channels in the Nervous System)
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