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Plant Bioactive Substances and Potential Applications
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Plant Bioactive Substances and Potential Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 712

Special Issue Editors

Dr. Magdalena Woźniak

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Guest Editor
Department of Chemistry, Faculty of Wood Technology, Poznań University of Life Sciences, Wojska Polskiego 75, 60625 Poznań, Poland
Interests: natural products; propolis; plant extracts; quantitative analysis of active compounds in natural products; biological activity of natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Karolina Hoppe

E-Mail Website
Guest Editor
Department of Chemistry, Faculty of Forest and Wood Technology, Poznan University of Life Sciences, Wojska Polskiego 75, 60-625 Poznań, Poland
Interests: analysis of mycotoxins in crops and in the environment; biological protection of cereals; Fusarium species; the use of natural endophytes to protect against fungal diseases; the use of oils in plant biological protection; PAH analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants are a rich source of bioactive compounds exhibiting a wide spectrum of biological activities, including: antibacterial, antioxidant, anti-inflammatory and anticancer. Biocomponents found in plants include groups of compounds such as phenolic compounds (flavonoids, as well as phenolic acids and their esters), tannins, alkaloids and terpenes. However, these are not the only groups of compounds with biological activity identified in the plant world. Therefore, the aim of this special issue is to collect original and review articles in order to provide the most up-to-date knowledge about plant extracts.

Suggested topics include:

  • identification of bioactive compounds found in plants
  • assessment of the biological activity of plant extracts and components isolated from them
  • development and validation of analytical methods for the identification and quantification of bioactive compounds in plants
  • indication of potential applications of plant extracts and their bioactive ingredients, including: in food, crop and wood protection.

Dr. Magdalena Woźniak
Dr. Karolina Gromadzka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • chemical composition
  • natural-based extracts
  • biological activity
  • antimicrobial activity
  • antioxidant effect

Published Papers (1 paper)

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Review

13 pages, 624 KiB  
Review
Investigation into the Neuroprotective and Therapeutic Potential of Plant-Derived Chk2 Inhibitors
by Monika Kisielewska, Michał Filipski, Kamil Sebastianka, Dobrawa Karaś, Klaudia Molik and Anna Choromańska
Int. J. Mol. Sci. 2024, 25(14), 7725; https://doi.org/10.3390/ijms25147725 - 15 Jul 2024
Viewed by 382
Abstract
Nature provides us with a rich source of compounds with a wide range of applications, including the creation of innovative drugs. Despite advancements in chemically synthesized therapeutics, natural compounds are increasingly significant, especially in cancer treatment, a leading cause of death globally. One [...] Read more.
Nature provides us with a rich source of compounds with a wide range of applications, including the creation of innovative drugs. Despite advancements in chemically synthesized therapeutics, natural compounds are increasingly significant, especially in cancer treatment, a leading cause of death globally. One promising approach involves the use of natural inhibitors of checkpoint kinase 2 (Chk2), a critical regulator of DNA repair, cell cycle arrest, and apoptosis. Chk2’s activation in response to DNA damage can lead to apoptosis or DNA repair, influencing glycolysis and mitochondrial function. In cancer therapy, inhibiting Chk2 can disrupt DNA repair and cell cycle progression, promoting cancer cell death and enhancing the efficacy of radiotherapy and chemotherapy. Additionally, Chk2 inhibitors can safeguard non-cancerous cells during these treatments by inhibiting p53-dependent apoptosis. Beyond oncology, Chk2 inhibition shows potential in treating hepatitis C virus (HCV) infections, as the virus relies on Chk2 for RNA replication in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), in which DNA damage plays a crucial role. Plant-derived Chk2 inhibitors, such as artemetin, rhamnetin, and curcumin, offer a promising future for treating various diseases with potentially milder side effects and broader metabolic impacts compared to conventional therapies. The review aims to underscore the immense potential of natural Chk2 inhibitors in various therapeutic contexts, particularly in oncology and the treatment of other diseases involving DNA damage and repair mechanisms. These natural Chk2 inhibitors hold significant promise for revolutionizing the landscape of cancer treatment and other diseases. Further research into these compounds could lead to the development of innovative therapies that offer hope for the future with fewer side effects and enhanced efficacy. Full article
(This article belongs to the Special Issue Plant Bioactive Substances and Potential Applications)
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