New Advances in Aquaporinopathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 4726
Special Issue Editors
Interests: aquaporin; kidney transporters; kidney channels, water and electrolyte metabolism; diabetes insipidus; hereditary kidney diseases
2. Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
Interests: aquaporin; membrane protein trafficking; kidney transporters; water and electrolyte metabolism; diabetes insipidus; chronic kidney disease
Special Issue Information
Dear Colleagues,
The first aquaporin (AQP) was discovered as a water channel protein of human red blood cell, but many of later AQP members permeate not only water but many small solutes, ions (chloride and nitrate), arsenate, boron, silicon and even gases (CO2, NH3 and NO). Beyond these heterogeneities in channel function, functions other than channel have been discovered, such as cell membrane adhesion (AQP4), signal transduction (AQP2), stimulator of cell migration and wound recovery (AQP1, 3), trigger of auto-immune system (AQP4) and mediator of inflammation (AQP3). However, until now, aquaporinopathy which includes diseases and disordered conditions caused by AQP's disfunction is recognized in a limited spectrum of diseases. Typical examples are hereditary nephrogenic diabetes insipidus (AQP2), congenital cataract (AQP1), neuromyelitis optica (AQP4) , obesity (AQP7) and Sjogren’s syndrome (AQP5). There are 13 members of AQP in human and they are conserved through the evolution, implying that they play indispensable roles for survival that are easily overlooked in comfortable environment in modern life. Understanding aquaporinopathy is anticipated to reveal novel therapeutic targets in many diseases. This special issue will welcome papers focusing on AQP-related diseases and abnormal states, and their pathophysiologies.
Prof. Sei Sasaki
Dr. Yumi Noda
Guest Editors
Manuscript Submission Information
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Keywords
- Aquaporin
- AQP
- aquaporinopathy
- nephrogenic diabetes insipidus
- neuromyelitis optica
- congenital cataracta
- obesity
- kidney
- brain edema
- water transport
