The Role of Autophagy Processes in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 16744
Special Issue Editors
Interests: autophagy; tumor biology; molecular biology; cell biology; cell signaling
Interests: virology; cancer biology; autophagy; infectious diseases; cell biology; signaling transduction
Special Issue Information
Dear Colleagues,
Autophagy processes regulate the developmental biology and progression of various diseases. In cancer, autophagy plays a diverse role in the oncogenic or tumor-suppressive functions in the different stages of cancer progression. Autophagy also coordinates its functions in the balance of metabolic homeostasis and the development of diabetes. Furthermore, autophagy deficiency is associated with the development of Parkinson’s disease, which is a neurodegenerative disease. In the viral infection areas, some viral infections induce autophagic activity in the host cells to enhance viral replication and facilitate the viral life cycle. Moreover, accumulating reports demonstrate that autophagy is not only a degradation pathway for component recycling in the cell but also an unconventional secretion process for specific cargo releasing. Some cytosolic proteins lack the signal peptides for trafficking from the endoplasmic reticulum and are secreted by different unconventional processes. Secretory autophagy participates in one of the unconventional secretion pathways. All these reports support the idea that clarifying the molecular mechanism of autophagy to strengthen our scientific knowledge is important.
In this Special Issue, we welcome original research articles, reviews, and short communications that focus on the field of autophagy research and aim to explore the molecular regulation of autophagy in physiology and pathology. Research areas may include (but not limited to) the following: cancer, diabetes mellites, neurodegenerative diseases, metabolic diseases, infectious diseases, cell biology, immunity, and developmental biology. We are hoping that this special issue could shed some light on the molecular research of autophagy in various human diseases.
We look forward to receiving your contributions.
Dr. Shan-Ying Wu
Dr. Ying-Ray Lee
Dr. Lan Sheng-Hui
Guest Editors
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Keywords
- autophagy
- cancer
- metabolic disease
- cell signaling
- molecular mechanisms
- therapeutic strategy
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