Mast Cells in Human Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 38815
Special Issue Editor
Interests: inflammation; neuroinflammation; gut-brain axis; mast cells; learning and memory
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Increasing evidence suggests that mast cells play a crucial role in human health and diseases.
Mast cells are known to be involved cells in allergic reactions through degranulation and the release of a variety of mediators with vasoactive, inflammatory, and nociceptive activities. Mast cells are sensors of the environment, able to respond promptly and selectively. Mast cells are intriguing and multifactorial cells and play a leading role in various pathological conditions.
The localization of mast cells within the tissue and their expression of specific mediators such as chymases or tryptases is important evidence from the diagnostic point of view. Chronic inflammation is a common mediator of various disorders which include many pathological conditions, pain, migraine, depression, anxiety, autoimmune diseases, fibromyalgia, but also Alzheimer’s disease, multiple sclerosis, atherosclerosis, and cardiovascular diseases. Modulation of the hyperactivity of mast cells and the reduction of the release of inflammatory factors could constitute a new frontier of therapeutic intervention aimed at preventing chronic inflammation.
Topics:
- New developments in mast cell management in human disorders
- New molecular insights in mast cell control
- Mast cells and microbiome
- Mast cells and nociception
- Mast cells and food allergy
- Mast cells and neuroinflammation
- Mast cells and stress
Dr. Giovanna Traina
Guest Editor
Manuscript Submission Information
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Keywords
- mast cells
- human diseases
- pain
- cardiovascular diseases
- microbiome
- food allergy
- stress
- cancer