Interferons in Lupus
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 24407
Special Issue Editor
Special Issue Information
Dear Colleagues,
Systemic lupus erythematosus (SLE) is a debilitating autoimmune disorder affecting millions of people world-wide. The pathogenesis of SLE is diverse among patients driven by dysregulated immune cells, cytokines, and hormones, resulting in a variety of symptoms such as nephritis, vasculitis, myocarditis, pleuritis, etc. Over the past several decades, the identification of elevated levels of type I interferons in a significant proportion of SLE patients has aided in the enrichment of our understanding of the pathogenesis of SLE. In addition, other interferons such as interferon-lambda, interferon-kappa, and interferon-gamma have also been suggested to play important roles in disease pathogenesis in both animal models and SLE patients.
This Special Issue, “Interferons in Lupus”, welcomes original research and review articles with a focus on cellular, molecular ,and mechanistic inducers, modulators, and responders of interferons in SLE, LE, and animal models of lupus.
Small-molecule inhibitors or specific antibodies targeting interferon induction, production, and/or effector functions offer new therapeutic strategies that may aid in controlling SLE pathogenesis. However, an understanding of the widespread immunological effects attributed to interferons is imperative for such agents to become available to SLE patients. What types of interferons are involved in disease pathogenesis at different times? What signal(s) induces interferon production in SLE patients and animal models of lupus? When does the induction of interferons take place, and when are these best targeted? Is it feasible to target the inducer(s) therapeutically? What cell subsets are involved in the production of interferons, and how do these relate to disease symptoms? What cell subsets respond to interferons, and how?
Dr. Trine N. Jorgensen
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lupus
- nephritis
- myocarditis
- vasculitis
- type I interferons
- interferon-γ
- regulation
- interference
- treatment
- immune cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.