Lipoprotein Nanoparticles for Diagnosis and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 36894
Special Issue Editors
Interests: lipoprotein (structure, function, and metabolism); drug delivery; optimization of therapeutic payload delivery; lipoprotein mimetics; apolipoprotein mimetics; anticancer drugs
Special Issues, Collections and Topics in MDPI journals
Interests: HDL mimetic nanoparticles; HDL and Imaging; SR-B1 Receptors; LRP family receptors; cancer; neurodegenerative disorders
Special Issue Information
Dear Colleagues,
Lipoprotein-based drug delivery has been pursued by several research groups since the 1980s. Nevertheless, despite many advantages over existing technologies, no lipoprotein-based formulation appears close to be tested in clinical trials. Significant research efforts on rHDL are involved in atherosclerosis treatment. Moreover, synthetic lipoproteins (rHDL and rLDL) have been utilized in targeting various malignancies (e.g. cancer) of various tissues including but not limited to adrenal, testes, ovary, liver, pancreas, breast, prostate and brain in animal models. Moreover, owing to their inflammatory and antioxidant properties, these nanoparticles have become relevant in inflammatory and diseases originating due to oxidative stress. HDL and Apo-A1 is known to play critical role in immunity as well. Several reports have implicated rHDL nanoparticles for therapy of neurodegenerative diseases such as Alzheimer's. Considering the wide array of applications of these mimics of endogenous HDL, this special edition titled “Lipoprotein Nanoparticles for Diagnosis and Therapy” of the International Journal of Molecular Sciences is intended to explore the paths for overcoming current barriers to the delivery of anti-cancer agents using reconstituted HDL or HDL mime tics by reporting on the latest developments on by the leading research groups in this area.
Prof. Dr. Andras G. Lacko
Dr. Sangram Raut
Guest Editors
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Keywords
- Recent advances HDL and HDL mimetic nanoparticles
- Tumor selective delivery
- Tumor imaging
- Specific therapeutic applications
- Challenges to overcome for translation
- HDL and antioxidant properties
- Apolipoproteins and inflammatory properties
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