Mast Cells in Human Health and Diseases—3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1235
Special Issue Editor
Interests: Inflammation; neuroinflammation; gut-brain axis; mast cells; learning and memory
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Increasing amounts of evidence suggest that mast cells play a crucial role in human health and diseases.
Mast cells are known to be cells involved in allergic reactions through degranulation and the release of a variety of mediators with vasoactive, inflammatory, and nociceptive activities. Mast cells are sensors of the environment, able to respond promptly and selectively. Mast cells are intriguing and multifactorial cells and play a leading role in various pathological conditions.
The localization of mast cells within the tissue and their expression of specific mediators, such as chymases or tryptases, are important pieces of evidence from the diagnostic point of view. Chronic inflammation is a common mediator of various disorders which include many pathological conditions, pain, migraine, depression, anxiety, autoimmune diseases, and fibromyalgia, but also Alzheimer’s disease, multiple sclerosis, atherosclerosis, and cardiovascular diseases. The modulation of the hyperactivity of mast cells and the reduction in the release of inflammatory factors could constitute new frontiers of therapeutic interventions aimed at preventing chronic inflammation.
Topics:
- New developments in mast cell management in human disorders;
- New molecular insights in mast cell control;
- Mast cells and the microbiome;
- Mast cells and nociception;
- Mast cells and food allergies;
- Mast cells and neuroinflammation;
- Mast cells and stress.
Dr. Giovanna Traina
Guest Editor
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Keywords
- mast cells
- human diseases
- pain
- cardiovascular diseases
- microbiome
- food allergy
- stress
- cancer
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