Molecular Mechanisms of Sperm Activation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 32353
Special Issue Editor
Special Issue Information
Dear Colleagues,
Spermatozoa in the testes are still immature, unable to move, and not fertile, even though spermatogenesis and spermiogenesis are completed. After ejaculation or spawning of semen, sperm acquire motility and fertility and can accomplish fertilization. This process is often species-specific in animals characterized by external fertilization and allows successful conspecific fertilization. Sperm activation in many animals including mammals occurs through common molecular mechanisms, whose elucidation is important to distinguish shared pathways of fertilization from species-specific authentication mechanisms.
This Special Issue will focus on the different aspects of sperm activation: initiation and activation of sperm motility, guidance of sperm swimming (including sperm chemotaxis), capacitation and hyperactivation, and induction of the acrosome reaction. It intends to create a platform for up-to-date high-quality publications on sperm activation during fertilization. Studies on the regulation mechanisms of sperm flagellar motility, the role of ion channels such as CatSper in sperm activation, the identification of molecules mediating sperm activation, etc., are welcome. We also welcome articles on applied research based on sperm activation, concerning, for example, livestock breeding, aquaculture technology, and male infertility. We hope that this Special Issue will provide a broad view of spermatology, from basic biology in marine invertebrates to reproductive medicine, fostering new research in reproductive biology areas.
Dr. Manabu Yoshida
Guest Editor
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Keywords
- Sperm motility
- Flagellar beating
- Capacitation and hyperactivation
- Sperm guidance
- Acrosome reaction
- Seminal plasma
- Ovarian fluid
- Sperm-egg interaction
- Asthenozoospermia
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