Molecular Research on Microenvironment and Pancreatic Tumorigenesis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 14760
Special Issue Editor
Interests: pancreatic cancer; microenvironment; extracellular vesicles; intercellular communication; macrophages; cancer-associated fibroblasts; monocyte; neural remodeling; peri-neural invasion
Special Issue Information
Dear Colleagues,
While being a growing field of research to improve pancreatic cancer therapies and patient care, the role of non-tumoral cells composing the intra-tumoral microenvironment still needs to be better understood. Indeed, known to impact tumor cells’ proliferation, metabolism, cell death and resistance to therapies among others, the translational potential of studies to deepen the impact of this microenvironmental network on pancreatic cancer failed to significantly improve patients’ survival.
Composed mainly of vascular, nervous and immune cells that are embedded in a cancer-associated fibroblast-driven extracellular matrix, understanding the complex and multiscale connection shaping this intra-tumoral microenvironment, and the consequent crosstalk with tumor cells, should open new avenues to target both cellular and acellular active components of such aggressive tumors.
This Special Issue intends to deepen, at the molecular level, the impact of the intratumoral microenvironment on pancreatic cancer development and spreading, as well as its ability to avoid immune surveillance and favor therapeutic resistance.
Dr. Richard Tomasini
Guest Editor
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Keywords
- Cancer-associated fibroblasts
- Adipocytes
- Immune system
- Endothelial cells
- Nervous system
- Extracellular matrix
- Secreted factors
- Extracellular vesicles
- Biomarkers
- Therapeutic resistance
- Metabolism
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