Molecular Effects of Phytochemicals on Cholesterol Metabolism Genes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 23045
Special Issue Editor
Interests: phytochemicals; food chemistry; lipid metabolism; leukemia; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dysregulation of cholesterol metabolism is not only associated with atherosclerotic cardiovascular diseases but also other diseases, such as cancers and neurodegenerative disorders. Modulation of plasma cholesterol levels may be achieved by diet and lifestyle changes or the use of pharmacological interventions for the regulation of cholesterol metabolism genes such as HMGCR inhibitors (statins), PCSK9 or Mylip/Idol inhibitors (LDLR degradation inhibitors), and NPC1L1 inhibitors (cholesterol absorption inhibitors) can significantly improve the clinical outcome of these events. In recent years, phytochemicals such as polyphenols, flavonoids, isoflavonoids, and terpenoids have been reported to possess a broad spectrum of pharmacological and biological activities and are considered promising agents for the maintenance of cholesterol homeostasis. Therefore, I will highlight the molecular effects of phytochemicals in the regulation of genes and signaling pathways involved in the cholesterol metabolism. In this Special Issue, we invite paper submissions regarding the molecular effects and underlying mechanisms of phytochemicals on the modulation of cholesterol metabolism genes for the management of lipid dysregulation in the prevention or treatment of chronic diseases.
Prof. Dr. Jui-Hung Yen
Guest Editor
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Keywords
- atherosclerotic cardiovascular diseases
- cancers
- neurodegenerative disorders
- cholesterol metabolism genes
- phytochemicals
- polyphenols
- flavonoids
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