Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Newer Developments in the Field of Glomerular Diseases
share announcement

Newer Developments in the Field of Glomerular Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 617

Special Issue Editor

Dr. Sophia Lionaki

E-Mail Website
Guest Editor
Department of Nephrology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece
Interests: glomerular disease; IgA nephropathy; ANCA vasculitis and glomerulonephritis; membranous nephropathy; lupus nephritis; complement-mediated glomerular diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The field of glomerular diseases has made significant progress over recent decades with new concepts of genetic risk factors, etiologic events, nephritogenic responses, and treatment of the major immunologically mediated types of glomerular injury. These include post-infectious glomerulonephritis, IgA nephropathy, anti-GBM antibody disease, ANCA-associated glomerulonephritis, lupus nephritis complement-mediated glomerular diseases, and podocytopathies such as minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy. Yet, identification of mechanistic pathways for these diseases has evolved into emerging therapies involving therapeutic targets as a result of newly appreciated roles for older mediators, like complement and complement regulatory proteins. Ongoing advances in understanding the immunopathogenesis of each of these entities also offer many opportunities for future therapeutic interventions.

This Special Issue welcomes articles either highlighting recent developments or continuing efforts to elucidate the pathogenesis and guide the management of glomerular diseases.

We are excited to host this Special Issue and welcome solicited and unsolicited submissions to create a special collection of articles that will help to advance the state of knowledge in this field.

Dr. Sophia Lionaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glomerual diseases
  • post-infectious glomerulonephritis
  • IgA nephropathy
  • anti-GBM antibody glomerulonephritis
  • ANCA-associated glomerulonephritis
  • lupus nephritis complement-mediated glomerular diseases
  • minimal change disease
  • focal segmental glomerulosclerosis
  • membranous nephropathy

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

9 pages, 246 KiB  
Article
The Role of TNF-α in the Pathogenesis of Idiopathic Nephrotic Syndrome and Its Usefulness as a Marker of the Disease Course
by Agnieszka Pukajło-Marczyk and Danuta Zwolińska
J. Clin. Med. 2024, 13(7), 1888; https://doi.org/10.3390/jcm13071888 - 25 Mar 2024
Viewed by 502
Abstract
Background: The pathogenesis of idiopathic nephrotic syndrome (INS) has not been fully explained. Among the likely factors, tumor necrosis factor - alpha (TNF-α) is considered. We aimed to evaluate the TNF-α (sTNF-α, uTNF-α) levels in the serum and urine of INS children, [...] Read more.
Background: The pathogenesis of idiopathic nephrotic syndrome (INS) has not been fully explained. Among the likely factors, tumor necrosis factor - alpha (TNF-α) is considered. We aimed to evaluate the TNF-α (sTNF-α, uTNF-α) levels in the serum and urine of INS children, with the aim of determining its association with proteinuria, and of determining its usefulness as a marker of the disease severity. Methods: Fifty-one examined patients were divided into subgroups depending on the number of relapses as follows: group IA—first episode; group IB—more than two relapses, and according to treatment modality; group IIA—glucocorticosteroids (GS) alone; and group IIB—GS with immunosuppressants. Healthy age-matched children served as the control group. Results: sTNF-α and uTNF-α levels were significantly increased in active phases in the whole INS group compared to the control group. They decreased in remission, but remained significantly higher when compared to the control group. During remission in the IB group, sTNF-α levels were significantly higher than in IA, whereas, in the relapse phase, these values were similar. In the IA group, a positive correlation between proteinuria and sTNF-α was demonstrated. Conclusions: Our findings suggest that TNF-α plays a role in the development of INS, and may be used as a prognostic marker, as well as an indicator for the continuation of therapy. Additional research is required to verify this statement. Full article
(This article belongs to the Special Issue Newer Developments in the Field of Glomerular Diseases)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop