Latest Advances in Clinical Diagnosis and Treatment of Rheumatoid Arthritis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 15 November 2024 | Viewed by 1218

Special Issue Editors


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Guest Editor
1. Rheumatology Department, ULS Santa Maria, Lisbon Academic Medical Centre, 1649-035 Lisbon, Portugal
2. Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon Academic Medical Centre, 1649-035 Lisbon, Portugal
Interests: rheumatoid arthritis; synovitis; Sjögren’s syndrome; clinical outcomes; biomarkers; precision medicine

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Guest Editor
1. Division of Rheumatology, Department of Internal Medicine 3, Medical University of Vienna, 1090 Vienna, Austria
2. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Interests: outcomes research; clinical and observational trials; digital health; collaborative research; autoantibodies; inflammatory arthritis

Special Issue Information

Dear Colleagues,

Recent years have brought cutting-edge advancements in the clinical diagnosis and treatment of rheumatoid arthritis (RA), addressing pivotal challenges in the field. With a focus on elucidating the current research status and tackling core issues, this Special Issue aims to enhance the understanding and management of RA. Encompassing a broad scope, contributions span innovative diagnostic techniques, novel therapeutic modalities, and emerging prognostic markers. Through this Special Issue, we endeavor to foster interdisciplinary collaboration, promote knowledge dissemination, and stimulate further investigations aimed at refining RA management strategies. Together, we aspire to empower clinicians and researchers in their quest to alleviate the burden of RA and improve the quality of life for affected individuals.

Dr. Vasco C. Romão
Dr. Paul Studenic
Guest Editors

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Keywords

  • rheumatoid arthritis
  • diagnosis
  • clinical practice
  • treatment
  • management
  • prognosis

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Published Papers (1 paper)

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Research

13 pages, 791 KiB  
Article
Therapeutic Maintenance of Janus Kinase Inhibitors in Real Life for Rheumatoid Arthritis: Retrospective Study
by Camille Farnos, Vincent Barbier, Marie Doussiere, Valentine Deprez, Yannis Hamidou, Pierre Antoine Bruy, Jean Marc Sobhy Danial and Vincent Goeb
J. Clin. Med. 2024, 13(16), 4608; https://doi.org/10.3390/jcm13164608 - 7 Aug 2024
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Abstract
Background/Objectives: Janus kinase inhibitors (JAKis) belong to a new class of targeted oral drugs that have been added to the therapeutic arsenal for rheumatoid arthritis (RA). The aim of this study was to evaluate the efficacy and safety profiles of these four available [...] Read more.
Background/Objectives: Janus kinase inhibitors (JAKis) belong to a new class of targeted oral drugs that have been added to the therapeutic arsenal for rheumatoid arthritis (RA). The aim of this study was to evaluate the efficacy and safety profiles of these four available molecules (tofacitinib, baricitinib, filgotinib, and upadacitinib) in real life. Methods: A retrospective, single-center observational study including all patients treated with JAKis for RA from 1 October 2017 to 1 December 2023. We assessed the maintenance rate at 24 months, which is an indirect reflection of the clinical and biological safety and efficacy profiles. Results: The 76 patients in our study were thus treated for the first time with anti-JAK, including 55 patients with baricitinib (BAR), 9 patients with tofacitinib (TOF), 4 patients with upadacitinib (UPA), and 8 patients with filgotinib (FIL). The majority of our patients had BAR introduced as the first intention. The therapeutic maintenance at 2 years for all our patients was 50%. The average maintenance duration was 8.6 months and was similar in all the groups. Of the 76 patients included in this study treated with Baricitinib (72.3%), 38 (50%) discontinued their treatment after two years of follow-up. Conclusions: Although this retrospective study is subject to various biases, it shows that the persistence rates of the four JAKi molecules in daily practice did not differ significantly, thus confirming the long-term efficacy of these drugs. Full article
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