Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Biomarkers and Lung Cancer: Clinical Application
share announcement

Biomarkers and Lung Cancer: Clinical Application

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 568

Special Issue Editor

Dr. Roberto Gasparri

E-Mail Website
Guest Editor
Department of Thoracic Surgery, European Institute of Oncology, Via Giuseppe Ripamonti 435, 20141 Milan, Italy
Interests: lung cancer; thoracic surgery; thoracic diseases; early diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lung cancer is the leading cause of cancer-related mortality worldwide. The five-year survival rate is strongly associated with late diagnosis (23% for stage III–IV vs. 67% for the early stages).

Screening programs based on low-dose computed tomography (LD-CT) determined a 20% reduction in lung cancer mortality. However, it is not very suitable as a screening test for the mass population due to its high costs, radiation, and false positive rate. Thus, early diagnosis is essential for its therapeutic and prognostic implications. In this scenario, the absence of a non-invasive and inexpensive screening tool is the main issue for the population, particularly for high-risk subjects. Consequently, the discovery of lung cancer biomarkers in body fluids such as blood, urine, stool, saliva, sputum and breath could play a key role in the diagnosis, prognosis and treatment of lung cancer.

The goal of this Special Issue is to share new knowledge about the latest biomolecules and techniques available for minimally invasive screening of lung cancer as well as the critical limitations that require future improvement in order to upgrade the diagnosis, prognosis and treatment of lung cancer patients.

We will include clinically oriented research papers and reviews, with a strong focus on the topics of early diagnosis of lung cancer and biomarkers.

We hope this Special Issue will be of interest to you, and we look forward to receiving your contributions.

Dr. Roberto Gasparri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • early diagnosis
  • prognosis
  • biomarkers
  • body fluids
  • liquid biopsy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

21 pages, 2835 KiB  
Article
Toll-like Receptors: Key Players in Squamous Cell Carcinoma Progression
by Jolanta Smok-Kalwat, Paulina Mertowska, Sebastian Mertowski, Stanisław Góźdź and Ewelina Grywalska
J. Clin. Med. 2024, 13(15), 4531; https://doi.org/10.3390/jcm13154531 - 2 Aug 2024
Viewed by 371
Abstract
Background/Objectives Lung squamous cell carcinoma (SCC) is one of the major subtypes of lung cancer, characterized by diverse molecular pathways and variable clinical outcomes. This study focused on assessing the levels of TLR-2, TLR-3, TLR-4, TLR-7, TLR-8, and TLR-9 on peripheral blood lymphocytes [...] Read more.
Background/Objectives Lung squamous cell carcinoma (SCC) is one of the major subtypes of lung cancer, characterized by diverse molecular pathways and variable clinical outcomes. This study focused on assessing the levels of TLR-2, TLR-3, TLR-4, TLR-7, TLR-8, and TLR-9 on peripheral blood lymphocytes in patients with newly diagnosed SCC compared to a group of healthy controls, in the context of disease development and patient survival, conducted over three years. The study aimed to investigate the differences in TLR expression between SCC patients and healthy people and to understand their role in the development of the disease and patient survival over three years. Methods: The study included the assessment of TLR-2, TLR-3, TLR-4, TLR-7, TLR-8, and TLR-9 levels on peripheral blood lymphocytes in patients with newly diagnosed SCC and in the control group. The expression of TLRs was measured using flow cytometry, and the soluble forms of the tested TLRs were measured using enzyme-linked immunosorbent assays. All the analyses were conducted over a three-year period from the time patients were recruited to the study. The obtained test results were statistically analyzed. Results: Results showed statistically significant differences in TLR expression between the groups, with higher TLR levels correlating with an advanced stage of disease and poorer survival rates. This suggests that the deregulation of TLR levels may be involved in promoting tumor development and influencing its microenvironment. Conclusions: The research, conducted over three years, indicates the need for further research on the role of TLRs in SCC, including their potential use as therapeutic targets and biomarkers. This may help to increase the effectiveness of standard treatments and improve clinical outcomes in patients with SCC. Full article
(This article belongs to the Special Issue Biomarkers and Lung Cancer: Clinical Application)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop