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Treatment of Spine Degenerative Diseases: Latest Advances and Prospects
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Treatment of Spine Degenerative Diseases: Latest Advances and Prospects

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3916

Special Issue Editor

Prof. Dr. Yukun Zhang

E-Mail Website
Guest Editor
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Interests: minimally invasive spinal surgery; lumbar disc herniation; cervical spondylosis; intervertebral disc degeneration; tissue engineering; regenerative biomaterials

Special Issue Information

Dear Colleagues,

Spinal degenerative diseases are common in patients who undergo spine surgery and have been a hot topic and focus of research in  recent years. Spinal degeneration is closely related to various factors, such as biomechanics, age, genetics, and nutrition. The treatment for spinal degenerative diseases should be specific to different pathological stages. In the current treatment strategy, the treatment is mainly divided into conservative treatment and surgery. The aim of conservative treatment is to eliminate or reduce clinical symptoms by eliminating local inflammation and tissue edema. Surgical treatment involves decompression, bone grafting and fusion to rebuild the balance and stability of the spine in order to improve the quality of life of the patient.

With the continuous development of new technologies and methods, the treatments of spinal degenerative diseases have entered a new phase, with new minimally invasive techniques being refined and developed, and new attempts being made in the practice of translational medicine. The aim of this Special Issue is to provide a comprehensive overview of the important discoveries in the diagnosis and treatment of spinal degenerative diseases and the latest clinical research advances. Therefore, clinicians and scholars in spine surgery or related fields worldwide are encouraged to submit their clinical studies or reviews to this journal.

Prof. Dr. Yukun Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spine degenerative diseases
  • intervertebral disc degeneration
  • minimally invasive surgery
  • complications
  • lateral lumbar interbody fusion
  • lumbar disc herniation
  • degenerative lumbar spondylolisthesis
  • lumbar spinal stenosis

Published Papers (2 papers)

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Research

14 pages, 1008 KiB  
Article
The Fate of Pre-Existing L5-S1 Degeneration following Oblique Lumbar Interbody Fusion of L4-L5 and Above
by Dong-Ho Kang, Ji Hwan Kim, Bong-Soon Chang, Hyoungmin Kim, Dongook Kim, Sanghyun Park, Seong Hwa Hong and Sam Yeol Chang
J. Clin. Med. 2023, 12(23), 7463; https://doi.org/10.3390/jcm12237463 - 1 Dec 2023
Viewed by 828
Abstract
Background: Previous studies have identified various risk factors for adjacent segment disease (ASD) at the L5-S1 level after fusion surgery, including preoperative sagittal imbalance, longer fusion, and preoperative disc degeneration. However, only a few studies have explored the risk factors for ASD at [...] Read more.
Background: Previous studies have identified various risk factors for adjacent segment disease (ASD) at the L5-S1 level after fusion surgery, including preoperative sagittal imbalance, longer fusion, and preoperative disc degeneration. However, only a few studies have explored the risk factors for ASD at the L5-S1 level after oblique lumbar interbody fusion (OLIF) at the L4-L5 level and above. This study aimed to identify the risk factors for symptomatic ASD at the L5-S1 level in patients with pre-existing degeneration after OLIF at L4-L5 and above. Methods: We retrospectively reviewed the data of patients who underwent OLIF at L4-L5 and above, with a minimum follow-up period of 2 years. Patients with central stenosis or Lee grade 2 or 3 foraminal stenosis at L5-S1 preoperatively were excluded. Patients were divided into ASD and non-ASD groups based on the occurrence of new-onset L5 or S1 radicular pain requiring epidural steroid injection (ESI). The clinical and radiological factors were analyzed. Logistic regression was used to identify the risk factors for ASD of L5-S1. Results: A total of 191 patients with a mean age ± standard deviation of 68.6 ± 8.3 years were included. Thirty-four (21.7%) patients underwent ESI at the L5 root after OLIF. In the logistic regression analyses, severe disc degeneration (OR (95% confidence interval (CI)): 2.65 (1.16–6.09)), the presence of facet effusion (OR (95% CI): 2.55 (1.05–6.23)), and severe paraspinal muscle fatty degeneration (OR (95% CI): 4.47 (1.53–13.05)) were significant risk factors for ASD in L5-S1. Conclusions: In this study, the presence of facet effusion, severe disc degeneration, and severe paraspinal muscle fatty degeneration at the L5-S1 level were associated with the development of ASD at L5-S1 following OLIF at L4-L5 and above. For patients with these conditions, surgeons could consider including L5-S1 in the fusion when considering OLIF at the L4-L5 level and above. Full article
(This article belongs to the Special Issue Treatment of Spine Degenerative Diseases: Latest Advances and Prospects)
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12 pages, 1236 KiB  
Article
Stand-Alone Oblique Lumbar Interbody Fusion (OLIF) for the Treatment of Adjacent Segment Disease (ASD) after Previous Posterior Lumbar Fusion: Clinical and Radiological Outcomes and Comparison with Posterior Revision Surgery
by Massimo Miscusi, Sokol Trungu, Luca Ricciardi, Stefano Forcato, Amedeo Piazza, Alessandro Ramieri and Antonino Raco
J. Clin. Med. 2023, 12(8), 2985; https://doi.org/10.3390/jcm12082985 - 20 Apr 2023
Cited by 1 | Viewed by 2352
Abstract
Background: Radiological evidence of adjacent segment disease (ASD) has been reported to have a prevalence of more than 30% and several risk factors have been reported. The aim of this study is to evaluate the clinical and radiological outcomes of patients with [...] Read more.
Background: Radiological evidence of adjacent segment disease (ASD) has been reported to have a prevalence of more than 30% and several risk factors have been reported. The aim of this study is to evaluate the clinical and radiological outcomes of patients with symptomatic ASD treated with stand-alone OLIF and compare results with a posterior revision surgery cohort. Methods: This is a retrospective case-control study. Clinical-patient-reported outcomes were obtained at preoperative, postoperative and final follow-up visits using the Short Form (SF-36) scale, the Oswestry Disability Index (ODI) and the visual analog scale (VAS). Radiological measures include lumbar lordosis (LL), segmental lordosis (SL), pelvic incidence-lumbar lordosis (PI-LL) mismatch, segmental coronal Cobb angle and intervertebral disc height (DH). The data are compared with a retrospective series of patients that underwent a posterior revision surgery for ASD. Results: Twenty-eight patients in the OLIF group and 25 patients in the posterior group meet inclusion criteria. The mean ages at the time of the surgery are 65.1 years and 67.5, respectively. The mean follow-up time is 36.1 months (range of 14–56). The clinical outcomes significantly improve from preoperative values from the surgery in both groups. The radiological parameters are significantly improved postoperatively and were maintained at the last follow-up in both groups. A statistically significant difference is observed between the two groups for minor complication rate, length of surgery, blood loss and DH restoration. Conclusions: Stand-alone OLIF is an effective and safe technique with low morbidity and complication rates for the treatment of selected patients with symptomatic ASD following a previous lumbar fusion. Full article
(This article belongs to the Special Issue Treatment of Spine Degenerative Diseases: Latest Advances and Prospects)
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