Reabsorbable Magnesium Scaffold in Clinical Practice: State of the Art and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 2911

Special Issue Editor


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Guest Editor
Department of Invasive Cardiology, Centro Cardiologico Monzino, IRCCS, Milan, Italy
Interests: interventional cardiology; structural cardiology; intravascular imaging; bifurcation; bioresorbable scaffold

Special Issue Information

Dear Colleagues,

Bioresorbable scaffolds (BRS) may represent a step forward in the treatment of coronary artery lesions. The advantages of this device are mainly due to its potential long-term benefits, limiting stent thrombosis, restenosis, neoatherosclerosis, constant vascular inflammation, and providing complete vascular restoration. Current guidelines, based on historical data on poly-L-lactide (PLLA) scaffolds, recommend the use of any bioresorbable scaffold, exclusively within controlled clinical trials (class III recommendation, evidence level C). Nevertheless, a metallic resorbable magnesium scaffold (RMS), Magmaris (Biotronik AG, Bulach, Switzerland), was launched on the market. Metallic and antithrombotic properties make this scaffold an attractive technology, its mechanical properties substantially differ from those of polymer-based scaffolds and the experience with previous procedures has shown that a standardized implantation technique and optimal patient and lesion selection are key factors for a successful implantation. Following the first consensus document on the use of this device, recently, a panel of expert Italian cardiologists published a second consensus document on the best practices for Magmaris implantation, in a selected patient population. The aim of this Special Issue is to highlight the benefits of this new technology and discuss new potential future indication in a global context.

Dr. Stefano Galli
Guest Editor

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Keywords

  • Resorbable magnesium scaffold
  • Bioresorbable scaffolds
  • Coronary artery lesions
  • Neoatherosclerosis
  • Restenosis
  • Stent thrombosis
  • Vascular restoration

Published Papers (1 paper)

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Research

10 pages, 462 KiB  
Article
The 1-Year Safety and Efficacy Outcomes of Magmaris, Novel Magnesium Bioresorbable Vascular Scaffolds in Diabetes Mellitus Patients with Acute Coronary Syndrome
by Adrian Włodarczak, Magdalena Łanocha, Marek Szudrowicz, Mateusz Barycki, Alicja Gosiewska, Jan Jakub Kulczycki, Maciej Lesiak, Adrian Doroszko and Piotr Rola
J. Clin. Med. 2021, 10(14), 3166; https://doi.org/10.3390/jcm10143166 - 18 Jul 2021
Cited by 8 | Viewed by 2340
Abstract
Background: Diabetes mellitus (DM) is one of the major risk factors contributing to Acute Coronary Syndromes (ACS) and is associated with an increased risk of adverse clinical outcomes following percutaneous coronary intervention (PCI), even when the second generation of drug-eluting stents (DES) is [...] Read more.
Background: Diabetes mellitus (DM) is one of the major risk factors contributing to Acute Coronary Syndromes (ACS) and is associated with an increased risk of adverse clinical outcomes following percutaneous coronary intervention (PCI), even when the second generation of drug-eluting stents (DES) is used. In order to overcome the disadvantages of permanent caging of a vessel with metallic DES, bioresorbable scaffold (BRS) technology has been recently developed. However, the prognosis of patients with DM and ACS treated with PCI via subsequent implantation of Magmaris (Biotronik, Berlin, Germany)—a novel magnesium-bioresorbable scaffold—is poorly investigated. Methods: A total of 193 consecutive subjects with non-ST elevation acute coronary syndrome (NSTE-ACS) who, from October 2016 to March 2020, received one or more Magmaris scaffolds were enrolled in this study. The diabetic group was compared with non-diabetic subjects. Results: There were no significant differences in the occurrence of primary endpoints (cardiovascular death, myocardial infarction, and in-stent thrombosis) and principal secondary endpoints (target-lesion failure, scaffold restenosis, death from any reason, and other cardiovascular events) between the two compared groups in a 1-year follow-up period. Conclusions: The early 1-year-outcome of magnesium bioresorbable scaffold (Magmaris) seems to be favorable and suggests that this novel BRS is safe and effective in subjects with NSTE-ACS and co-existing DM. Full article
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