From Vessel to Muscle—an Integrative Approach to Ischemic Heart Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 851

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Department of Internal Medicine, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: cardiology; internal medicine; heart failure; atherosclerosis; arterial hypertension
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Special Issue Information

Dear Colleagues,

Ischemic heart disease (IHD) is a common health problem in the general population worldwide. It brings high morbidity and mortality and negatively impacts the quality of life, work capacity, and social integration. The pressure that IHD exerts on the healthcare system is enormous. First of all, there is a large and constantly growing number of patients with IHD who require long-term monitoring and treatment. Second, there are acute life-threatening events that compel rapid, complex, and resource-intensive interventions.

Sustained efforts are being made every day to ensure that advances in the field are translated into daily practice. The diagnosis and treatment of acute and chronic coronary syndromes have become extremely complex and are moving steadily towards personalized medicine. The integrative approach to IHD brings different specialists into a single team. Clinical and interventional cardiologists work together with cardiovascular surgeons, radiologists, nuclear medicine specialists, emergency doctors, and intensivists to achieve the best care for patients with IHD.   

Multimodal assessment of coronary circulation, diagnosis of electrical and mechanical disturbances triggered by myocardial ischemia, endovascular therapies, and highly specialized coronary and cardiac procedures and devices represent daily challenges for attending physicians. We are convinced that therapeutic success lies in a synchronous multispecialty approach, carried out with the highest level of competence. We invite colleagues with expertise in the diagnosis and treatment of ischemic heart disease to share their experience with us, through original articles and reviews, to improve the care of our patients.

Prof. Dr. Irina Iuliana Costache Enache
Prof. Dr. Ciprian Rezus
Dr. Minerva Codruta Badescu
Guest Editors

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Keywords

  • ischemic heart disease
  • atherosclerotic plaque features
  • microvascular dysfunction
  • coronary vasospasm
  • percutaneous transluminal coronary angioplasty
  • coronary artery bypass grafting
  • cardiac magnetic resonance imaging
  • coronary computed tomography angiography

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Published Papers (1 paper)

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19 pages, 2133 KB  
Systematic Review
Clinical Impact of Blood Pressure Variability in Kidney Transplant Patients: A Systematic Review and Meta-Analysis
by Mehmet Kanbay, Alexandru Dan Costache, Crischentian Brinza, Ozgur Aktas, Busra Z. Bayici, Sevde Odemis, Candan Genc, Alexandru Burlacu, Irina Iuliana Costache Enache, Andreea Simona Covic, Pantelis Sarafidis, Masanari Kuwabara and Adrian Covic
Life 2025, 15(8), 1271; https://doi.org/10.3390/life15081271 - 11 Aug 2025
Viewed by 741
Abstract
Background: The association between blood pressure (BP) dipping profiles and kidney function among chronic kidney disease (CKD) patients has been well established within the literature, but studies conducted on kidney transplant (KT) patients remain limited. Individual KT studies have small sample sizes and [...] Read more.
Background: The association between blood pressure (BP) dipping profiles and kidney function among chronic kidney disease (CKD) patients has been well established within the literature, but studies conducted on kidney transplant (KT) patients remain limited. Individual KT studies have small sample sizes and conflicting results. Meta-analysis overcomes these limitations by pooling data to increase statistical power and provide robust clinical guidance. This meta-analysis systematically assesses the impact of BP patterns on KT and CKD populations, aiming to highlight improved BP management strategies in these populations. Materials and methods: A comprehensive search was conducted up to September 9th, 2024, using multiple electronic databases. Results: The current study included 7 studies with a total of 788 patients. KT recipients showed a higher prevalence of non-dipper blood pressure profile than CKD patients. Also, those with a dipper profile had a significantly higher estimated glomerular filtration rate (eGFR) compared to non-dippers and reverse dippers, implying better graft function. No significant differences were observed in acute rejection risk, proteinuria, renal resistive index, cholesterol, or triglycerides across blood pressure profiles. Conclusions: These findings reveal a high prevalence of non-dipping blood pressure profiles in KT and CKD patients, linked to worse renal and cardiovascular outcomes, while also highlighting the need for ambulatory blood pressure monitoring and tailored BP management strategies in these high-risk populations to potentially improve outcomes. However, the observational nature of available studies limits causal inference, and further prospective research is required to establish definitive therapeutic recommendations. Full article
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