Advances in Medical Imaging of Animal Models for Human Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 26 November 2025 | Viewed by 751

Special Issue Editors


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Guest Editor
Department of Medical Research and Development, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
Interests: molecular imaging; image analysis; drug delivery system; animal model; radiolabeling PET and SPECT
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute of Stem Cell and Translational Cancer Research, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
Interests: molecular biology; tumor biology; syngeneic murine model; glycolipid; tumor microenvironment and PET

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Advances in Medical Imaging of Animal Models for Human Diseases", will explore the use of medical imaging techniques such as MRI, CT, SPECT, PET, and US in animal models to better understand and treat human diseases. We are seeking original research and review articles demonstrating the successful application of advanced medical imaging techniques in small or large animal models. These techniques should investigate disease mechanisms, progression, treatment efficiency, and potential therapeutic strategies.

Submissions should specifically focus on medical imaging techniques applied to animal models in the fields of oncology, neurodegeneration, cardiology, GI diseases, and inflammation, as they relate to human diseases. We are particularly interested in research that deals with preclinical model establishment, translation, implementation challenges, and clinical application.

Our goal is to feature high-quality research that advances technology and translation research, making sophisticated human-like diseases more accessible and efficient. We also encourage contributions that advance medical imaging in less commonly used animal models.

Dr. Yihsiu Chung
Dr. Tsai-Hsien Hung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medical imaging
  • animal models
  • preclinical research
  • human disease
  • oncology

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Published Papers (1 paper)

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Research

16 pages, 1852 KB  
Article
Minimally-Invasive Imaging of Sublingual Vessels—A New Method to Study Microvascular Changes in Mice
by Ellen Dyminski Parente Ribeiro, Maryam Dastan, Ursula Bellut-Staeck, Juan Zhou and Christian Lehmann
Life 2025, 15(9), 1478; https://doi.org/10.3390/life15091478 - 20 Sep 2025
Viewed by 202
Abstract
Sepsis causes profound microcirculatory dysfunction, where heterogeneous capillary perfusion and abnormal vasomotion contribute to tissue hypoxia and organ failure. Sublingual videomicroscopy is established in large animals and humans to monitor these alterations, but this approach has not been applied in murine models. We [...] Read more.
Sepsis causes profound microcirculatory dysfunction, where heterogeneous capillary perfusion and abnormal vasomotion contribute to tissue hypoxia and organ failure. Sublingual videomicroscopy is established in large animals and humans to monitor these alterations, but this approach has not been applied in murine models. We developed a method to assess sublingual perfusion and vasomotion in mice using sidestream dark field (SDF) videomicroscopy. Male C57BL/6 mice were anesthetized, and sublingual vessels were imaged for 90 min. Perfusion and vasomotion parameters were assessed, and a Fast Fourier Transform was performed on vasomotion data to characterize the frequency components of rhythmic microvessel diameter changes. Another group of animals was administered lipopolysaccharide (LPS) intraperitoneally as a model of systemic inflammation in sepsis. LPS-treated mice exhibited a significant decline in the proportion of perfused vessels at 90 min and in the microvascular flow index. Very low-frequency vasomotion (0.005–0.15 Hz) declined in controls but was preserved during endotoxemia, suggesting an active microvascular tone response to inflammatory stress. This study establishes the first murine protocol for sublingual SDF imaging, allowing early detection of perfusion deficits and vasomotor changes in experimental sepsis. The minimal-invasive approach offers a translational platform for mechanistic and therapeutic studies in sepsis. Full article
(This article belongs to the Special Issue Advances in Medical Imaging of Animal Models for Human Diseases)
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