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Life
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New Advances in Chest and Lung Clinical Surgery
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New Advances in Chest and Lung Clinical Surgery

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3412

Special Issue Editor

Dr. Maria Teresa Congedo

E-Mail Website
Guest Editor
Fondazione Policlinico Gemelli IRCCS Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: early-stage lung cancer; mini-invasive thoracic surgery; target therapy; multimodal therapy

Special Issue Information

Dear Colleagues,

This Special Issue, ‘New Advances in Chest and Lung Clinical Surgery’, aims to highlight the novel diagnosis and treatment of chest and lung diseases. I am delighted to share with you that I have recently accepted an invitation to serve as the Guest Editor for a Special Issue of the journal Life (ISSN 2075-1729) with a five-year Impact Factor of 3.251. In this regard, I would be very pleased if you would agree to contribute an original research paper, or a focus review, to this issue.

Dr. Maria Teresa Congedo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • early-stage lung cancer
  • mini-invasive thoracic surgery
  • target therapy
  • multimodal therapy

Published Papers (2 papers)

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Review

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15 pages, 3910 KiB  
Review
The Role of Human Papilloma Virus (HPV) in Primary Lung Cancer Development: State of the Art and Future Perspectives
by Dania Nachira, Maria Teresa Congedo, Ettore D’Argento, Elisa Meacci, Jessica Evangelista, Carolina Sassorossi, Giuseppe Calabrese, Adriana Nocera, Khrystyna Kuzmych, Rosaria Santangelo, Guido Rindi and Stefano Margaritora
Life 2024, 14(1), 110; https://doi.org/10.3390/life14010110 - 10 Jan 2024
Cited by 1 | Viewed by 2177
Abstract
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Notably, the incidence of lung cancer among never-smokers, predominantly women, has been rising in recent years. Among the various implicated risk factors, human papilloma virus (HPV) may play a role [...] Read more.
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Notably, the incidence of lung cancer among never-smokers, predominantly women, has been rising in recent years. Among the various implicated risk factors, human papilloma virus (HPV) may play a role in the development of NSCLC in a certain subset of patients. The prevalence of high-risk HPV-DNA within human neoplastic lung cells varies across the world; however, the carcinogenetic role of HPV in NSCLC has not been completely understood. Bloodstream could be one of the routes of transmission from infected sites to the lungs, along with oral (through unprotected oral sex) and airborne transmission. Previous studies reported an elevated risk of NSCLC in patients with prior HPV-related tumors, such as cervical, laryngeal, or oropharyngeal cancer, with better prognosis for HPV-positive lung cancers compared to negative forms. On the other hand, 16% of NSCLC patients present circulating HPV-DNA in peripheral blood along with miRNAs expression. Typically, these patients have a poorly differentiated NSCLC, often diagnosed at an advanced stage. However, HPV-positive lung cancers seem to have a better response to target therapies (EGFR) and immune checkpoint inhibitors and show an increased sensitivity to platinum-based treatments. This review summarizes the current evidence regarding the role of HPV in NSCLC development, especially among patients with a history of HPV-related cancers. It also examines the diagnostic and prognostic significance of HPV, investigating new future perspectives to enhance cancer screening, diagnostic protocols, and the development of more targeted therapies tailored to specific cohorts of NSCLC patients with confirmed HPV infection. Full article
(This article belongs to the Special Issue New Advances in Chest and Lung Clinical Surgery)
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10 pages, 562 KiB  
Systematic Review
Pneumonectomy for Unilateral Proximal Interruption of Pulmonary Artery: A Case Series from the Literature
by Giovanni Mattioni, Mario Nosotti, Lorenzo Rosso, Alessandro Palleschi, Davide Tosi and Paolo Mendogni
Life 2023, 13(12), 2328; https://doi.org/10.3390/life13122328 - 12 Dec 2023
Viewed by 885
Abstract
Background: Unilateral proximal interruption of the pulmonary artery (UPIPA) is a rare congenital disease, and its optimal management remains undefined in the existing literature. The occasional necessity for pneumonectomy is still supported by limited evidence. Methods: A systematic review of the literature was [...] Read more.
Background: Unilateral proximal interruption of the pulmonary artery (UPIPA) is a rare congenital disease, and its optimal management remains undefined in the existing literature. The occasional necessity for pneumonectomy is still supported by limited evidence. Methods: A systematic review of the literature was conducted using the PubMed search engine, focusing on UPIPA cases that received pneumonectomy. Thirty-one pertinent articles were selected and included in the analysis. A case reported from our institution was included in the analysis. Results: We found 25 adults and seven children affected by UPIPA who received an indication for pneumonectomy, plus an additional case that was reported by our institution. Among adult patients, the predominant indication was hemoptysis (57%), followed by suspected or confirmed lung cancer (23%). Approximately 46% of surgical procedures were classified as urgent or emergent. Postoperative complications were observed in 36% of cases, with no recorded mortality. In pediatric cases, pneumonectomy was primarily a life-saving intervention, performed urgently or emergently in 75% of instances. A possible late complication in pediatric patients involves a mediastinal shift leading to respiratory distress, which may be mitigated using an inflatable prosthesis. Conclusions: Pneumonectomy achieves complete resolution of UPIPA symptoms. In the adult population, its primary indication is hemoptysis, with procedures conducted in both elective and urgent/emergent settings. Despite a mortality rate of zero, a notable proportion of patients may experience postoperative complications. In pediatric cases, the clinical presentation varies more extensively, and pneumonectomy is typically reserved for life-threatening situations, emphasizing the need for careful patient selection. Full article
(This article belongs to the Special Issue New Advances in Chest and Lung Clinical Surgery)
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