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New Horizons of Adipose Tissue Disorders: From Hormonal Issues to...
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New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 5132

Special Issue Editors

Dr. Laura Patton

E-Mail Website
Guest Editor
Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy
Interests: endocrinology
Special Issues, Collections and Topics in MDPI journals
Dr. Guido Gabriele

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, Università degli Studi di Siena, Siena, Italy
Interests: endocrinology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Adipose tissue disorders, especially regarding superficial adipose tissue or subcutaneous fibro-adipose tissue, and diseases involving the lymphatic system are not yet considered in the same manner as diseases of other organs or tissues by the medical/scientific community.

These disorders are therefore often not adequately studied by researchers and underestimated, consequently becoming the prerogative of non-healthcare professionals who deal with aesthetic pathologies.

Nonetheless, many years have now passed since the new vision and redefinition of adipose tissue as one of the major endocrine organs and a very important connection network between other endocrine–metabolic systems and other organs and tissues of the organism, e.g., the effects of leptin on the central nervous system and the regulation of fertility.

From the data emerging from studies carried out on rare diseases of adipose tissue, lipedema and tissue alterations linked to lymphedema, it is increasingly relevant to consider these diseases as primitive, which could originate from the tissue itself and not always be linked to changes in body weight, hormones or metabolism, and as diseases that do not only involve adipocytes, but the loose connective tissue with the extracellular matrix, other non-adipocyte cells and the entire micro- and macro-vascular and lymphatic systems.

We warmly invite you and your colleagues to submit original research articles, reviews, systematic reviews, meta-analyses and brief reports that address issues related to the future management and understanding of adipose and lymphatic tissue diseases, in particular lipedema and rare diseases of adipose tissue, as well as the clinical evaluation and instrumental diagnosis, treatment, prognosis, follow-up and prevention of these diseases.

Dr. Laura Patton
Dr. Guido Gabriele
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipose tissue
  • lipedema
  • lymphedema
  • obesity
  • matrix
  • vascular and lymphatic disorder
  • connective tissue diseases
  • dysbiosis
  • inflammation
  • pain

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Published Papers (2 papers)

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Research

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22 pages, 3710 KiB  
Article
Micromassage Compression Leggings Associated with Physical Exercise: Pilot Study and Example of Evaluation of the Clinical and Instrumental Effectiveness of Conservative Treatment in Lipedema
by Lorenzo Ricolfi, Valeria Reverdito, Guido Gabriele, Micaela Bortolon, Ilaria Macherelli, Piero Haag, Nicoletta De Santis, Massimo Guerriero and Laura Patton
Life 2024, 14(7), 854; https://doi.org/10.3390/life14070854 - 8 Jul 2024
Viewed by 3915
Abstract
We evaluated the effect of compression leggings with micromassage in association with physical activity on women with lipedema, not previously treated and without recent changes in body weight. The treatment resulted in an improvement in all subjective parameters, in spontaneous and evoked pain, [...] Read more.
We evaluated the effect of compression leggings with micromassage in association with physical activity on women with lipedema, not previously treated and without recent changes in body weight. The treatment resulted in an improvement in all subjective parameters, in spontaneous and evoked pain, in the volume of the limbs, in the absence of significant changes in body weight, and regardless of the duration of use, age, years of illness, the clinical stage, and body mass index (BMI). Evoked pain did not improve in areas affected by untreated lipedema; foot circumferences did not increase. We found a significant reduction in the thickness of subcutaneous adipose tissue (SAT) and skin evaluated in multiple points of the lower limb. Micromassage compression leggings are proposed as an integral part of conservative treatment. A method is proposed for the clinical evaluation of evoked pain, called the Progressive Pain Check (PPC), which allows for the calculation of a numerical score called the Ricolfi–Patton Score (RPS) and for the ultrasound evaluation of tissues. The method is simple and repeatable and allows for completion of the clinical evaluation of the patient at diagnosis and for an evaluation of the effects of various treatments, even applied to just one side of the body. Full article
(This article belongs to the Special Issue New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease)
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Review

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14 pages, 440 KiB  
Review
Closing the Gaps: An Integrative Review of Yoga’s Benefits for Lymphedema in Breast Cancer Survivors
by Sara Freguia, Daniela Platano, Danilo Donati, Federica Giorgi and Roberto Tedeschi
Life 2024, 14(8), 999; https://doi.org/10.3390/life14080999 - 11 Aug 2024
Viewed by 748
Abstract
Background: Dissection of the axillary lymph nodes during surgery for breast cancer with lymph node involvement is burdened by a complication: lymphedema. Approximately half of women undergoing axillary dissection suffer from it, with a notable impact in terms of perceived discomfort, presented quality [...] Read more.
Background: Dissection of the axillary lymph nodes during surgery for breast cancer with lymph node involvement is burdened by a complication: lymphedema. Approximately half of women undergoing axillary dissection suffer from it, with a notable impact in terms of perceived discomfort, presented quality of life, and alteration of body image. There is also no shortage of problems in the patient’s social and professional life. Methods: The present review aims to select Randomized Controlled Trials (RCTs) present in the literature regarding the effects of yoga as an alternative therapy in patients with breast cancer-related lymphedema. A search of four databases was undertaken: Cochrane, Pubmed, Scopus, and Web of Science. The searches were conducted on 19 May 2024, and updated to 30 June 2024 without date limits. RCTs without language limitations, in any context, and with any yoga variant were considered. Results: The postulated search strings highlighted a total of 69 potentially eligible studies. The study selection system consisted of two levels of screening, (1) abstract selection and (2) full-text selection, for a total of three studies included in the review. The three RCTs included involved mixed treatment sessions in an outpatient setting with a yoga teacher and at home using a DVD. In the various studies, the outcome measures concerned quality of life, ROM, spinal mobility, limb volume, and tissue induration. Conclusions: According to the analysis of the data obtained, yoga as an alternative therapy could be useful if combined with the usual care routine in women with lymphedema related to sensory cancer, in terms of improving physical, professional, and emotional quality of life and reducing symptoms such as fatigue, pain, and insomnia. Furthermore, yoga could bring about a reduction in tissue induration of the limb, greater spinal mobility evaluated in terms of improvement of the pelvic and kyphotic angle, and greater strength in shoulder abduction. Full article
(This article belongs to the Special Issue New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease)
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