Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1134

Special Issue Editors


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Guest Editor
Department of Biophysics, Medical University of Białystok, Mickiewicza 2a, 15-089 Białystok, Poland
Interests: interleukin; injury; markers of inflammatory response; metalloproteinases; protein DAMPs; proteasome; wound healing process; tissue damage
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, Poland
Interests: cancer; central nervous system diseases; cerebrospinal fluid; cytokines; biomarker; inflammation markers
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, Poland
Interests: cerebrospinal fluid; biomarker; central nervous system diseases; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation is a complex and necessary component of the body’s response to pathological conditions, such as infections, burns, stress, trauma, or immunologic reactions. Inflammation has been linked to numerous diseases, including arthritis, asthma, atherosclerosis, autoimmune diseases, diabetes, and cancer, as well as to conditions associated with aging. The inflammatory response involves the release of various inflammatory markers. The evaluation of biomarkers such as cytokines, growth factors, oxidative markers, and other molecular markers allows us to understand the progression of various disorders and tissue repair processes. Monitoring the levels of inflammatory markers in body fluids may be useful for diagnosing inflammation, as well as for monitoring disease treatment. The most frequently used inflammatory markers include acute-phase proteins and cytokines, predominantly TNF-α, interleukins 1β, 6, 8, 10, and 12, their receptors, and IFNγ. However, new markers of the inflammatory response and tissue damage that can provide valuable information about various pathological conditions are still being sought.

In this Special Issue, all articles, including original papers, reviews, and other forms of scientific communication that present valuable observations concerning common and novel markers of inflammation and tissue damage in various pathological conditions, are welcome.

Dr. Marzena Tylicka
Dr. Joanna Kamińska
Dr. Olga Koper-Lenkiewicz
Guest Editors

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Keywords

  • body fluids
  • cytokines
  • damage-associated molecular patterns (DAMPS)
  • inflammatory response
  • injury
  • markers of inflammation and tissue damage
  • metalloproteinases
  • novel markers
  • pathological conditions
  • proteasome
  • tissue damage
  • tissue repair processes
  • various diseases

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Published Papers (1 paper)

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Research

16 pages, 2630 KiB  
Article
Blood Growth Factor Levels in Patients with Systemic Lupus Erythematosus: High Neuregulin-1 Is Associated with Comorbid Cardiovascular Pathology
by Evgeny A. Ermakov, Mark M. Melamud, Anastasiia S. Boiko, Svetlana A. Ivanova, Alexey E. Sizikov, Georgy A. Nevinsky and Valentina N. Buneva
Life 2024, 14(10), 1305; https://doi.org/10.3390/life14101305 - 14 Oct 2024
Viewed by 654
Abstract
Patients with systemic lupus erythematosus (SLE) are known to frequently suffer from comorbid cardiovascular diseases (CVDs). There are abundant data on cytokine levels and their role in the pathogenesis of SLE, while growth factors have received much less attention. The aim of this [...] Read more.
Patients with systemic lupus erythematosus (SLE) are known to frequently suffer from comorbid cardiovascular diseases (CVDs). There are abundant data on cytokine levels and their role in the pathogenesis of SLE, while growth factors have received much less attention. The aim of this study was to analyze growth factor levels in SLE patients and their association with the presence of comorbid CVDs. The serum concentrations for the granulocyte-macrophage colony-stimulating factor (GM-CSF), nerve growth factor β (NGFβ), glial cell line-derived neurotrophic factor (GDNF), and neuregulin-1 β (NRG-1β) were determined in the SLE patients (n = 35) and healthy individuals (n = 38) by a Luminex multiplex assay. The NGFβ and NRG-1β concentrations were shown to be significantly higher in the total group of SLE patients (median [Q1–Q3]: 3.6 [1.3–4.5] and 52.5 [8.5–148], respectively) compared with the healthy individuals (2.9 [1.3–3.4] and 13.7 [4.4–42] ng/mL, respectively). The GM-CSF and GDNF levels did not differ. Interestingly, elevated NRG-1β levels were associated with the presence of CVDs, as SLE patients with CVDs had significantly higher NRG-1β levels (99 [22–242]) compared with the controls (13.7 [4.4–42]) and patients without CVDs (19 [9–80] ng/mL). The model for the binary classification of SLE patients with and without CVDs based on the NRG-1β level had an average predictive ability (AUC = 0.67). Thus, altered levels of growth factors may be associated with comorbid CVDs in SLE patients. Full article
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