Metabolism in Health and Disease 2020

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 14116

Special Issue Editors


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Guest Editor
School of Life Science, Handong Global University, Pohang, Korea
Interests: innate immunity; inflammation; immunometabolism; cell migration; autoimmunity; immunopathology; skin immunity; renal immunity; antigen presentation; T cell activation; macrophages; dendritic cells

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Guest Editor
Department of Molecular Life Science, Hanyang University, Ansan, Korea
Interests: cell death; cell senescence; inflammation; cancer; innate immunity; immunomodulatory signal transduction; immunometabolism; metabolic diseases; microbial metabolites

Special Issue Information

Dear Colleagues,

Metabolism is a hallmark of life and underlies most biological processes in both health and disease. Since Otto H. Warburg discovered anomalous metabolism in cancer cells around 100 years ago, researchers have been addressing the implication of metabolism in various physiological and pathological scenarios. Innovative systems biology tools have revolutionized metabolic research and are currently providing us with an overwhelming amount of data and new insights, which need to be put together to form a bigger picture. Particularly, immune cell metabolism has attracted much attention in translational research over the past decade and suggests novel therapeutic strategies in various pathologic states.

This Special Issue intends to present to the scientific community new and current information on how metabolism regulates physiological and pathological conditions as well as provide an overview of current metabolic research. We welcome original research, reviews, and short reports on various aspects of metabolic regulation related to health and disease as well as technical reports.

Prof. Dr. Jea-Hyun Baek
Prof. Dr. Chun Kim
Guest Editors

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Keywords

  • cancer metabolism
  • immunometabolism
  • metabolic disorders
  • metabolism in obesity
  • immune cell metabolism
  • metabolic reprogramming
  • mitochondrial dysfunction
  • mitochondrial disorders

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Published Papers (1 paper)

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Review

19 pages, 1812 KiB  
Review
Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
by Inseok Choi, Hyewon Son and Jea-Hyun Baek
Life 2021, 11(1), 69; https://doi.org/10.3390/life11010069 - 19 Jan 2021
Cited by 103 | Viewed by 13182
Abstract
The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins. In the eukaryotic system, the TCA cycle occurs completely in mitochondria, [...] Read more.
The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins. In the eukaryotic system, the TCA cycle occurs completely in mitochondria, while the intermediates of the TCA cycle are retained inside mitochondria due to their polarity and hydrophilicity. Under cell stress conditions, mitochondria can become disrupted and release their contents, which act as danger signals in the cytosol. Of note, the TCA cycle intermediates may also leak from dysfunctioning mitochondria and regulate cellular processes. Increasing evidence shows that the metabolites of the TCA cycle are substantially involved in the regulation of immune responses. In this review, we aimed to provide a comprehensive systematic overview of the molecular mechanisms of each TCA cycle intermediate that may play key roles in regulating cellular immunity in cell stress and discuss its implication for immune activation and suppression. Full article
(This article belongs to the Special Issue Metabolism in Health and Disease 2020)
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