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Novel Antimicrobial Polymers: Synthesis, Properties and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Polymeric Materials".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1601

Special Issue Editor


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Guest Editor
Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, Strzody 9, 44-100 Gliwice, Poland
Interests: polymers; polymeric materials; polymer properties; polymer characterization; structure–property relationships; dimethacrylate monomer synthesis; dental materials
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Special Issue Information

Dear Colleagues,

Polymer-based materials have a superior status in all engineering sciences that attempt to address modern technology requirements. However, particular applications require them to have antimicrobial properties. Their antibacterial, antifungal, or antiviral activity is in demand in different sectors, such as medicine, dentistry, pharmacy, food packaging, clothing, coatings, furniture, and civil engineering. The achievement of novel bioactive products results from a long and complex process. It must comply with the criteria of physicochemical, mechanical, and biological properties. Combining bioactivity with desired elasticity, high durability, and biocompatibility is the most difficult. Special attention is also paid to manufacturing simplicity and cost efficiency. Recent research trends indicate the high potential of polymers containing chemical groups with bioactive properties. They can have high antimicrobial activity and good performance characteristics and are often characterized by lower cytotoxicity than polymer composites containing low-molecular-weight and physically dispersed biocides. This Special Issue is to showcase research regarding preparing and characterizing novel monomers, polymers, and polymeric materials with antimicrobial properties. Detailed material characteristics in the context of potential applications and deeper discussions on structure–property relationships are also welcome.

Prof. Dr. Izabela Barszczewska-Rybarek
Guest Editor

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Keywords

  • antibacterial properties
  • antifungal properties
  • antiviral properties
  • cytotoxicity
  • polymers with quaternary ammonium groups
  • composites with antimicrobial nanoparticles
  • mechanical properties
  • physicochemical properties

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Published Papers (2 papers)

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Research

15 pages, 5760 KiB  
Article
From Facile One-Pot Synthesis of Semi-Degradable Amphiphilic Miktoarm Polymers to Unique Degradation Properties
by Maria Kupczak, Anna Mielańczyk, Tomasz Fronczyk, Patryk Drejka, Przemyslaw Ledwon and Dorota Neugebauer
Materials 2024, 17(11), 2684; https://doi.org/10.3390/ma17112684 - 2 Jun 2024
Viewed by 402
Abstract
We report a one-pot synthesis of well-defined A5B and A8B miktoarm star-shaped polymers where N,N-dimethylaminoethyl methacrylate (DMAEMA) and various cyclic esters such as ε-caprolactone (ε-CL), lactide (LA) and glycolide (GA) were used for the synthesis. Miktopolymers were obtained [...] Read more.
We report a one-pot synthesis of well-defined A5B and A8B miktoarm star-shaped polymers where N,N-dimethylaminoethyl methacrylate (DMAEMA) and various cyclic esters such as ε-caprolactone (ε-CL), lactide (LA) and glycolide (GA) were used for the synthesis. Miktopolymers were obtained by simultaneously carrying out atom transfer radical polymerization (ATRP) of DMAEMA, ring-opening polymerization (ROP) of cyclic esters, and click reaction between the azide group in gluconamide-based (GLBr5-Az) or lactonamide-based (GLBr8-Az) ATRP initiators and 4-pentyn-1-ol. The relatively low dispersity indices of the obtained miktoarm stars (Đ = 1.2–1.6) indicate that control over the polymerization processes was sustained despite almost complete monomers conversions (83–99%). The presence of salts from phosphate-buffered saline (PBS) in polymer solutions affects the phase transition, increasing cloud point temperatures (TCP) values. The critical aggregation concentration (CAC) values increased with a decreasing number of average molecular weights of the hydrophobic fraction. Hydrolytic degradation studies revealed that the highest reduction of molecular weight was observed for polymers with PCL and PLGCL arm. The influence of the composition on the miktopolymers hydrophilicity was investigated via water contact angle (WCA) measurement. Thermogravimetric analysis (TGA) disclosed that the number of arms and their composition in the miktopolymer affects its weight loss under the influence of temperature. Full article
(This article belongs to the Special Issue Novel Antimicrobial Polymers: Synthesis, Properties and Applications)
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21 pages, 10349 KiB  
Article
Influence of the Type of Soft Segment on the Selected Properties of Polyurethane Materials for Biomedical Applications
by Andrzej Puszka, Janusz W. Sikora and Aleksandra Nurzyńska
Materials 2024, 17(4), 840; https://doi.org/10.3390/ma17040840 - 9 Feb 2024
Cited by 1 | Viewed by 933
Abstract
This work presents the synthesis and characterization of new TPUs obtained by melt polyaddition using 1,1′-methanediylbis(4-isocyanatocyclohexane) (HMDI, Desmodur W®), a new unconventional chain extender, i.e., (methanediyldibenze-ne-4,1-diyl)dimethanediol, and five types of soft segments differing in structure and molar masses. The structure of [...] Read more.
This work presents the synthesis and characterization of new TPUs obtained by melt polyaddition using 1,1′-methanediylbis(4-isocyanatocyclohexane) (HMDI, Desmodur W®), a new unconventional chain extender, i.e., (methanediyldibenze-ne-4,1-diyl)dimethanediol, and five types of soft segments differing in structure and molar masses. The structure of the obtained polymers was determined (by using the Fourier transform infrared spectroscopy and X-ray diffraction methods), and the physicochemical (reduced viscosity, density), optical (UV-VIS), processing (MFR) and thermal (DSC and TGA-FTIR) as well as surface, antibacterial and cytotoxic properties were determined. Based on the results obtained, it can be stated that the type of soft segment used significantly affects the properties of the obtained polymers. The most favorable properties for use in medicine were demonstrated by materials based on a polycarbonate soft segment. Full article
(This article belongs to the Special Issue Novel Antimicrobial Polymers: Synthesis, Properties and Applications)
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