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Polymeric and Biopolymeric Particles: Controlled Release of Natural Products

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Polymeric Materials".

Deadline for manuscript submissions: closed (10 April 2023) | Viewed by 4932

Special Issue Editor


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Guest Editor
Development and Innovation Management (DMCDI), The Directorate of Research, The Technical University of Cluj-Napoca, Constantin Daicoviciu Street, no. 15, Cluj-Napoca, 400020 Cluj County, Romania
Interests: polymeric and biopolymeric particles; topographical and morphological characterization of three-dimensional surfaces at micro/nanoscale; development of new mathematical tools in the investigation of 3D surface quality; theoretic and applied research in advanced materials science in applied sciences; mechanical and tribological characterization of macro–micro–nanostructures; experimental techniques for micro/nanomechanical and micro/nanotribological characterization; fractal and multifractal geometry analysis and applications; polymers; molecular dynamics method
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Special Issue Information

Dear Colleagues,

This Special Issue is devoted to the application of the polymeric and biopolymeric particles in natural products, which have recently revolutionized the world of medicine, food industry, agriculture, and biotechnology with biocompatible and degradable natural biological materials. Modern measurement techniques used in recent years offer a powerful research tool to characterize the various parameters for a given nanoparticle, such as particle size, surface charge, morphology, stability, structure, cellular uptake, cytotoxicity, drug loading, and drug release. On the other hand, the latest developments in polymeric and biopolymeric particles in improving their efficacy, their methods of fabrication; their characterization in terms of size, surface charge, morphology, stability, structure, cellular uptake, cytotoxicity, drug loading, drug release; and their utilization in medicine and biotechnology are also discussed along with a promising future scope. This Special Issue also supports mechanical and tribological characterization of polymeric and biopolymeric macro-micro–nanoparticles. Topographic and morphological characterization of two- and three-dimensional surfaces at micro/nanoscale, including analysis and applications of fractal and multifractal geometry are welcome. In addition, polymeric and biopolymeric particles can act as efficient drug delivery vehicles for sustained, controlled and targeted release, aiming to improve the therapeutic effects and also reduce the side effects of the formulated drugs.

The scope of this Special Issue includes, but is not limited to:

  • Topography and morphology of polymeric and biopolymeric carriers;
  • Structure and properties of polymeric and biopolymeric carriers;
  • Physical-chemical properties and biological functionality;
  • Nanoparticles as carriers for controlled release;
  • Methods, tools, computerized simulation, and mathematical models for characterization of surface topography;
  • Fractal and multifractal geometry analysis and applications;
  • Design of innovative micro/nano biostructures of biocompatible natural products;
  • Fabrication and applications of polymeric and biopolymeric particles in natural products;
  • Delivery systems based on encapsulated essential oils;
  • Stability and shelf-life of delivery systems.

Dr. Ştefan Ţălu
Guest Editor

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Keywords

  • biopolymeric particles
  • controlled release
  • particles design
  • release mechanism
  • biological functionality
  • particles stability
  • particles application
  • novel materials
  • polymeric carriers

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Published Papers (2 papers)

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Research

21 pages, 7149 KiB  
Article
β-Cyclodextrin Nanosponges Inclusion Compounds Associated with Silver Nanoparticles to Increase the Antimicrobial Activity of Quercetin
by Sebastián Salazar Sandoval, Tamara Bruna, Francisca Maldonado-Bravo, Karen Bolaños, Sofía Adasme-Reyes, Ana Riveros, Nelson Caro, Nicolás Yutronic, Nataly Silva, Marcelo J. Kogan and Paul Jara
Materials 2023, 16(9), 3538; https://doi.org/10.3390/ma16093538 - 5 May 2023
Cited by 6 | Viewed by 2313
Abstract
This work aimed to synthesize and characterize a nanocarrier that consisted of a ternary system, namely β-cyclodextrin-based nanosponge (NS) inclusion compounds (ICs) associated with silver nanoparticles (AgNPs) to increase the antimicrobial activity of quercetin (QRC). The nanosystem was developed to overcome the therapeutical [...] Read more.
This work aimed to synthesize and characterize a nanocarrier that consisted of a ternary system, namely β-cyclodextrin-based nanosponge (NS) inclusion compounds (ICs) associated with silver nanoparticles (AgNPs) to increase the antimicrobial activity of quercetin (QRC). The nanosystem was developed to overcome the therapeutical limitations of QRC. The host–guest interaction between NSs and QRC was confirmed by field emission scanning electron microscopy (FE–SEM), X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), and proton nuclear magnetic resonance (1H–NMR). Moreover, the association of AgNPs with the NS–QRC was characterized using FE–SEM, energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ-potential, and UV–Vis. Finally, the antimicrobial activity of the novel formulations was tested, which depicted that the complexation of QRC inside the supramolecular interstices of NSs increases the inhibitory effects against Escherichia coli ATCC25922, as compared to that observed in the free QRC. In addition, at the same concentrations used to generate an antibacterial effect, the NS–QRC system with AgNPs does not affect the metabolic activity of GES–1 cells. Therefore, these results suggest that the use of NSs associated with AgNPs resulted in an efficient strategy to improve the physicochemical features of QRC. Full article
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26 pages, 4576 KiB  
Article
Pulsatile Controlled Release and Stability Evaluation of Polymeric Particles Containing Piper nigrum Essential Oil and Preservatives
by Sidney Gomes Azevedo, Ana Luisa Farias Rocha, Ronald Zico de Aguiar Nunes, Camila da Costa Pinto, Ştefan Ţălu, Henrique Duarte da Fonseca Filho, Jaqueline de Araújo Bezerra, Alessandra Ramos Lima, Francisco Eduardo Gontijo Guimarães, Pedro Henrique Campelo, Vanderlei Salvador Bagnato, Natalia Mayumi Inada and Edgar Aparecido Sanches
Materials 2022, 15(15), 5415; https://doi.org/10.3390/ma15155415 - 5 Aug 2022
Cited by 6 | Viewed by 2059
Abstract
Considerable efforts have been spent on environmentally friendly particles for the encapsulation of essential oils. Polymeric particles were developed to encapsulate the essential oil from Piper nigrum based on gelatin and poly–ε–caprolactone (PCL) carriers. Gas Chromatography ((Flame Ionization Detection (GC/FID) and [...] Read more.
Considerable efforts have been spent on environmentally friendly particles for the encapsulation of essential oils. Polymeric particles were developed to encapsulate the essential oil from Piper nigrum based on gelatin and poly–ε–caprolactone (PCL) carriers. Gas Chromatography ((Flame Ionization Detection (GC/FID) and Mass Spectrometry (GC/MS)), Atomic Force Microscopy (AFM), Nanoparticle Tracking Analysis (NTA), Confocal Laser Scanning Microscopy (CLSM), Attenuated Total Reflectance–Fourier-transform Infrared Spectroscopy (ATR–FTIR), and Ultraviolet–Visible (UV–VIS) spectroscopy were used for the full colloidal system characterization. The essential oil was mainly composed of β-caryophyllene (~35%). The stability of the encapsulated systems was evaluated by Encapsulation Efficiency (EE%), electrical conductivity, turbidity, pH, and organoleptic properties (color and odor) after adding different preservatives. The mixture of phenoxyethanol/isotialzoni-3-one (PNE system) resulted in enhanced stability of approximately 120 and 210 days under constant handling and shelf-life tests, respectively. The developed polymeric system presented a similar controlled release in acidic, neutral, or basic pH, and the release curves suggested a pulsatile release mechanism due to a complexation of essential oil in the PCL matrix. Our results showed that the developed system has potential as an alternative stable product and as a controlling agent, due to the pronounced bioactivity of the encapsulated essential oil. Full article
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