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Medicina
Special Issues
Early Detection and Clinical Treatment of Acute Kidney Injury
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Early Detection and Clinical Treatment of Acute Kidney Injury

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Urology & Nephrology".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 6621

Special Issue Editor

Dr. Yu-Jang Su

E-Mail Website
Guest Editor
1. Division of Toxicology, Department of Emergency Medicine, MacKay Memorial Hospital, Taipei, Taiwan
2. Department of Medicine, MacKay Medical College, New Taipei City, Taiwan
3. MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan
4. Department of Nursing, Yuanpei University of Medical Technology, Hsinchu. Taiwan
Interests: resuscitation; CPR; emergency management; emergency treatment; cardiopulmonary resuscitation; critical care medicine; airway management; intensive care medicine; sepsis; ventilation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute kidney injury is commonly seen in daily practice, especially in those patients admitted to emergency departments and intensive care units. 

The goal of this Special Issue is to collate articles on the detection, treatment, and prevention of acute kidney injury.

The cutting-edge research: Warning signs and treatment strategies for patients with acute kidney injury.

The articles, reviews, opinions, and case reports are all welcome.

Dr. Yu-Jang Su
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute kidney injury
  • poisoning
  • trauma
  • infectious disease
  • critical care

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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9 pages, 513 KiB  
Article
A Comparative Analysis of Toxicology and Non-Toxicology Care in Intoxicated Patients with Acute Kidney Injury
by Chi-Syuan Pan, Chun-Hung Chen, Wei-Kung Chen, Han-Wei Mu, Kai-Wei Yang and Jiun-Hao Yu
Medicina 2024, 60(12), 1997; https://doi.org/10.3390/medicina60121997 - 3 Dec 2024
Viewed by 925
Abstract
Background and Objectives: Intoxicated patients with acute kidney injury (AKI) experience high morbidity and mortality. While prior studies suggest that toxicology care settings improve outcomes, the impact of care settings on patients with AKI remains unclear. This study aimed to compare the [...] Read more.
Background and Objectives: Intoxicated patients with acute kidney injury (AKI) experience high morbidity and mortality. While prior studies suggest that toxicology care settings improve outcomes, the impact of care settings on patients with AKI remains unclear. This study aimed to compare the outcomes of intoxicated patients with AKI managed in toxicology versus non-toxicology care settings. Materials and Methods: This retrospective cohort study included intoxicated patients admitted to a tertiary hospital between January 2022 and December 2023. Patients were categorized into toxicology and non-toxicology care settings. Demographic characteristics, clinical outcomes focusing on mortality and length of hospital stay, and evaluation scores were compared. Results: A total of 31 intoxicated patients with AKI were included in the study. There were no significant differences in mortality or hospital length of stay between toxicology and non-toxicology care settings. However, the mortality rate in the AKI group was significantly higher (16%) compared to intoxicated patients without AKI (1.9%). Additionally, hospital stays were consistently longer in the AKI group than in the non-AKI group across all age groups. Conclusions: Hospital length of stay and mortality did not differ significantly between toxicology and non-toxicology care settings for intoxicated patients with AKI. However, both hospital length of stay and mortality were notably higher in patients with AKI compared to those without AKI. Full article
(This article belongs to the Special Issue Early Detection and Clinical Treatment of Acute Kidney Injury)
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11 pages, 946 KiB  
Article
Perioperative Marinobufagenin (MBG) Measurement May Improve Acute Kidney Injury Risk Assessment in Patients Undergoing Major Cardiac Surgery: A Proof-of-Concept Study
by Davide Bolignano, Giuseppe Filiberto Serraino, Patrizia Pizzini, Federica Jiritano, Mariateresa Zicarelli, Belinda Spoto, Marco Mobrici, Michela Musolino, Désirée Napolitano, Alessandra Testa, Michele Andreucci, Pasquale Mastroroberto and Giuseppe Coppolino
Medicina 2024, 60(7), 1079; https://doi.org/10.3390/medicina60071079 - 30 Jun 2024
Cited by 1 | Viewed by 1540
Abstract
Background and Objectives: Acute kidney injury (AKI) remains a significant complication following major cardiac surgery. Marinobufagenin (MBG), a cardiotonic steroid involved in sodium balance and blood pressure regulation, has been linked to organ damage after ischemia–reperfusion events. This pilot, prospective study investigates the [...] Read more.
Background and Objectives: Acute kidney injury (AKI) remains a significant complication following major cardiac surgery. Marinobufagenin (MBG), a cardiotonic steroid involved in sodium balance and blood pressure regulation, has been linked to organ damage after ischemia–reperfusion events. This pilot, prospective study investigates the utility of circulating MBG to improve AKI risk assessment in cardiac surgery patients as a stand-alone biomarker and after inclusion in a validated risk model (STS-AKI score). Materials and Methods: We included 45 patients undergoing elective cardiac surgery. The MBG levels were measured preoperatively and at 4, 8, and 12 h post-surgery. The AKI was defined according to the KDIGO guidelines. Statistical analyses assessed the diagnostic and prognostic utility of MBG and its integration with the STS-AKI score. Results: An AKI occurred in 26.7% of the patients. The STS-AKI score performed well in this cohort (AUC: 0.736). The MBG levels displayed a decreasing trend in the whole population after surgery (p = 0.02). However, in the AKI patients, MBG increased at 4 and 8 h before decreasing at 12 h post-surgery. The MBG changes from the baseline to 8 h and from 8 to 12 h post-surgery showed a remarkable diagnostic accuracy for an AKI (AUCs: 0.917 and 0.843, respectively). Integrating these MBG changes with the STS-AKI score significantly improved the model performance, including discrimination, calibration, and risk reclassification. Conclusions: The MBG measurement, particularly any dynamic changes post-surgery, enhances AKI risk stratification in cardiac surgery patients. Integrating MBG with the STS-AKI score offers more accurate risk predictions, potentially leading to better patient management and outcomes. Full article
(This article belongs to the Special Issue Early Detection and Clinical Treatment of Acute Kidney Injury)
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Review

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12 pages, 335 KiB  
Review
Poisoning-Induced Acute Kidney Injury: A Review
by Ching-Hsiang Yu, Lan-Chi Huang and Yu-Jang Su
Medicina 2024, 60(8), 1302; https://doi.org/10.3390/medicina60081302 - 12 Aug 2024
Cited by 2 | Viewed by 3102
Abstract
Acute kidney injury (AKI) is a debilitating, multi-etiological disease that is commonly seen in clinical practice and in the emergency department. In this review, we introduce the definition, symptoms, and causes of poisoning-related AKI; we also discuss its mechanisms, risk factors, and epidemiology, [...] Read more.
Acute kidney injury (AKI) is a debilitating, multi-etiological disease that is commonly seen in clinical practice and in the emergency department. In this review, we introduce the definition, symptoms, and causes of poisoning-related AKI; we also discuss its mechanisms, risk factors, and epidemiology, as well as elaborate on the relevant laboratory tests. Subsequently, we discuss the treatment strategies for toxin- and substance-related AKI caused by Glafenin, antimicrobial agents, lithium, contrast media, snake venom, herbicides, ethylene glycol, synthetic cannabinoids, cocaine, heroin, and amphetamines. Finally, for a comprehensive overview of poisoning-related AKI, we review the management, prevention, and outcomes of this condition. Full article
(This article belongs to the Special Issue Early Detection and Clinical Treatment of Acute Kidney Injury)
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