Gut Microbiota and Gastrointestinal Cancer: Pathways to Progression and Opportunities for Intervention
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 323
Special Issue Editors
Interests: bacterial pathogenesis; pancreatic cancer; vaccine and drug development
Special Issues, Collections and Topics in MDPI journals
Interests: radiation oncology; cancer biology; lipids metabolism
Interests: infectious diseases; host-pathogen interaction; bacterial infection; viral infection; gut microbiome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The human gut microbiota, consisting of trillions of microorganisms, plays a crucial role in maintaining overall health, particularly within the gastrointestinal (GI) system. Recent research has uncovered a complex relationship between the gut microbiota and gastrointestinal cancers, which include colorectal, gastric, pancreatic, and esophageal cancers. Dysbiosis, or an imbalance in the gut microbiome, has been increasingly recognized as a key factor in the pathogenesis of these cancers. Not only does the microbiota influence the development of malignancies, but it also affects tumor progression, metastasis, and response to therapy. This Special Issue (SI) aims to explore the various mechanisms by which gut microbiota contributes to gastrointestinal cancer progression, with a focus on microbial-induced inflammation, immune modulation, and metabolic alterations. Additionally, the SI will investigate the emerging opportunities for microbiota-targeted interventions, including probiotics, prebiotics, dietary modifications, and fecal microbiota transplantation, as promising therapeutic approaches to combat cancer and improve patient outcomes.
By integrating cutting-edge research, this Special Issue will contribute to a better understanding of the intricate interactions between gut microbiota and gastrointestinal cancers, providing novel insights that could lead to more effective diagnostic and therapeutic strategies.
Dr. Vikas Kumar Somani
Dr. Naoshad Muhammad
Dr. Somya Aggarwal
Guest Editors
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Keywords
- gut microbiota
- gastrointestinal cancer
- dysbiosis
- colorectal cancer
- gastric cancer
- pancreatic cancer
- esophageal cancer
- cancer progression
- tumor microenvironment
- inflammation
- immune modulation
- metabolic alterations
- probiotics
- prebiotics
- microbial therapies
- fecal microbiota transplantation
- cancer immunotherapy
- tumor-associated microbiome
- gut–brain axis
- microbiome modulation
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