Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 895
Special Issue Editors
Interests: lipidomics; metabolomics; hyphenated mass spectrometry techniques
Interests: lipidomics; metabolomics; liquid chromatography–mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the past few decades, advances in LC-MS technology have led to the expansion of metabolomics among the “omics” disciplines. On one hand, the unpaired sensitivity and versatility of MS platforms supported the development of analytical methods where tenths to hundreds of metabolites were successfully identified and quantified in a single run. On the other hand, the improvements in the field of separation science and the progressive increase in the employment of ion mobility MS provided further tools to address the unambiguous identification of isomeric species. Nowadays, the use of high-throughput LC-MS methods in combination with the latest bioinformatics tools can be reliably exploited to deepen our understanding of complex biological systems and improve the characterization of complex food matrices through targeted or untargeted metabolomics.
This Special Issue focuses on the application of innovative LC-MS approaches for animal and plant metabolomic studies. Careful attention has been dedicated to the use of MS-based strategies for the identification of lipids and low-to-average mass (<2000 Da) metabolites. The synergic use of spectroscopic and chemical tools (e.g., derivatization and reactivity evaluation) for structure elucidation is also a topic of interest. This Special Issue is also oriented toward the development and application of (un)targeted LC-MS methods for metabolomic qualitative and quantitative studies.
Dr. Andrea Castellaneta
Prof. Dr. Ilario Losito
Guest Editors
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Keywords
- liquid chromatography
- high-resolution and multi-stage mass spectrometry
- lipidomics
- structure elucidation
- LC-MS methods for metabolite screening
- quantitative method development
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