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Metabolites
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Metabolic Research in Drosophila melanogaster
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Metabolic Research in Drosophila melanogaster

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 8758

Special Issue Editor

Prof. Dr. Youngseok Lee

E-Mail Website
Guest Editor
Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 2707, Korea
Interests: taste; sleep; temperature; memory; metabolism

Special Issue Information

Dear Colleagues,

The small insect Drosophila melanogaster, or vinegar fly, represents one of the most famous model organisms in genetics and biomedical research. As a trackable model organism, the D. melanogaster research toolbox contains many functional genetics tools, as well as genomics tools, such as transcriptomics, proteomics, and metabolomics. D. melanogaster has 20,000~25,000 genes (humans ~35,000) and 0.1 million neurons (humans ~100 billion). About 75% of known human disease genes have a recognizable match in the genome of vinegar flies. Furthermore, 50% of fly protein sequences have mammalian homologs. The fly is being used to study mechanisms underlying aging and oxidative stress, immunity, diabetes, circadian rhythm, cancer, and drug abuse. This Special Issue is devoted to recent applications of metabolic research to study the metabolism in D. melanogaster. However, it is not limited to the D. melanogaster, so research concerning other insects, such as mosquitoes and bees, is also welcome. We are happily considering original articles and technically updated protocols, as well as review articles, devoted to different aspects of the field of research.

Prof. Dr. Youngseok Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Drosophila melanogaster
  • Metabolism
  • Metabolic regulation
  • Feeding
  • Insects
  • Metabolomics

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Published Papers (2 papers)

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Research

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13 pages, 28257 KiB  
Article
The Impact of Microbiome and Microbiota-Derived Sodium Butyrate on Drosophila Transcriptome and Metabolome Revealed by Multi-Omics Analysis
by Fan Zhou, Biaodi Liu, Xin Liu, Yan Li, Luoluo Wang, Jia Huang, Guanzheng Luo and Xiaoyun Wang
Metabolites 2021, 11(5), 298; https://doi.org/10.3390/metabo11050298 - 6 May 2021
Cited by 17 | Viewed by 4333
Abstract
The host microbiome plays an important role in regulating physiology through microbiota-derived metabolites during host-microbiome interactions. However, molecular mechanism underly host-microbiome interactions remains to be explored. In this study, we used Drosophila as the model to investigate the influence of microbiome and microbiota-derived [...] Read more.
The host microbiome plays an important role in regulating physiology through microbiota-derived metabolites during host-microbiome interactions. However, molecular mechanism underly host-microbiome interactions remains to be explored. In this study, we used Drosophila as the model to investigate the influence of microbiome and microbiota-derived metabolite sodium butyrate on host transcriptome and metabolome. We established both a sterile Drosophila model and a conventional Drosophila model to demonstrate the role of sodium butyrate. Using multi-omics analysis, we found that microbiome and sodium butyrate could impact host gene expression patterns in both the sterile Drosophila model and the conventional Drosophila model. The analysis of gut microbial using 16S rRNA sequencing showed sodium butyrate treatment also influenced Drosophila bacterial structures. In addition, Drosophila metabolites identified by ultra-high performance liquid chromatography-MS/MS were shown to be affected by sodium butyrate treatment with lipids as the dominant changed components. Our integrative analysis of the transcriptome, the microbiome, and the metabolome data identified candidate transcripts that are coregulated by sodium butyrate. Taken together, our results reveal the impact of the microbiome and microbiota-derived sodium butyrate on host transcriptome and metabolome, and our work provides a better understanding of host-microbiome interactions at the molecular level with multi-omics data. Full article
(This article belongs to the Special Issue Metabolic Research in Drosophila melanogaster)
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Review

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12 pages, 1970 KiB  
Review
Salt Sensation and Regulation
by Sonali Puri and Youngseok Lee
Metabolites 2021, 11(3), 175; https://doi.org/10.3390/metabo11030175 - 17 Mar 2021
Cited by 7 | Viewed by 3663
Abstract
Taste sensation and regulation are highly conserved in insects and mammals. Research conducted over recent decades has yielded major advances in our understanding of the molecular mechanisms underlying the taste sensors for a variety of taste sensations and the processes underlying regulation of [...] Read more.
Taste sensation and regulation are highly conserved in insects and mammals. Research conducted over recent decades has yielded major advances in our understanding of the molecular mechanisms underlying the taste sensors for a variety of taste sensations and the processes underlying regulation of ingestion depending on our internal state. Salt (NaCl) is an essential ingested nutrient. The regulation of internal sodium concentrations for physiological processes, including neuronal activity, fluid volume, acid–base balance, and muscle contraction, are extremely important issues in animal health. Both mammals and flies detect low and high NaCl concentrations as attractive and aversive tastants, respectively. These attractive or aversive behaviors can be modulated by the internal nutrient state. However, the differential encoding of the tastes underlying low and high salt concentrations in the brain remain unclear. In this review, we discuss the current view of taste sensation and modulation in the brain with an emphasis on recent advances in this field. This work presents new questions that include but are not limited to, “How do the fly’s neuronal circuits process this complex salt code?” and “Why do high concentrations of salt induce a negative valence only when the need for salt is low?” A better understanding of regulation of salt homeostasis could improve our understanding of why our brains enjoy salty food so much. Full article
(This article belongs to the Special Issue Metabolic Research in Drosophila melanogaster)
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