Natural Metabolites on Gut Microbiome Modulation

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 13162

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, Ohio University, Athens, OH 45701, USA
Interests: gut microbiome; gut metabolites; bacterial infection; probiotics; bacteriophages

Special Issue Information

Dear Colleagues,

Gut microbiome plays a major role in the maintenance of human heath, while gut microbiome deviations are involved in the progress and development of human diseases. Modulation of gut microbiome in a healthy state has been a promising strategy for maintaining human health and disease therapy. Natural metabolites, including primary and secondary metabolites from plants, fungi and bacteria, are important resources for developing gut microbiome modulators. Although some natural metabolites have demonstrated potential roles in gut microbiome modulation, more studies are needed to distinguish novel natural metabolites and explore how they improve human health and combat human diseases via modulating gut microbiome. This Special Issue engages with, but is not limited to the following topics:

  • Studying the structures and roles of natural metabolites on gut microbiome;
  • New techniques on developing novel natural metabolites as gut microbiome modulators;
  • Optimization of known natural metabolites as gut microbiome modulators;
  • Roles of natural metabolites on human health and diseases through modulating gut microbiome;
  • Mechanisms linking natural metabolites and gut microbiome as well as human health conditions.

Dr. Shaohua Wang
Guest Editor

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Keywords

  • natural metabolites
  • gut microbiome
  • gut microbiome modulator
  • human health
  • human diseases

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Published Papers (3 papers)

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Research

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17 pages, 3031 KiB  
Article
Functional Muffins Exert Bifidogenic Effects along with Highly Product-Specific Effects on the Human Gut Microbiota Ex Vivo
by Stef Deyaert, Jonas Poppe, Lam Dai Vu, Aurélien Baudot, Sarah Bubeck, Thomas Bayne, Kiran Krishnan, Morgan Giusto, Samuel Moltz and Pieter Van den Abbeele
Metabolites 2024, 14(9), 497; https://doi.org/10.3390/metabo14090497 - 14 Sep 2024
Viewed by 1455
Abstract
GoodBiome™ Foods are functional foods containing a probiotic (Bacillus subtilis HU58™) and prebiotics (mainly inulin). Their effects on the human gut microbiota were assessed using ex vivo SIFR® technology, which has been validated to provide clinically predictive insights. GoodBiome™ Foods (BBM/LCM/OSM) [...] Read more.
GoodBiome™ Foods are functional foods containing a probiotic (Bacillus subtilis HU58™) and prebiotics (mainly inulin). Their effects on the human gut microbiota were assessed using ex vivo SIFR® technology, which has been validated to provide clinically predictive insights. GoodBiome™ Foods (BBM/LCM/OSM) were subjected to oral, gastric, and small intestinal digestion/absorption, after which their impact on the gut microbiome of four adults was assessed (n = 3). All GoodBiome™ Foods boosted health-related SCFA acetate (+13.1/14.1/13.8 mM for BBM/LCM/OSM), propionate (particularly OSM; +7.4/7.5/8.9 mM for BBM/LCM/OSM) and butyrate (particularly BBM; +2.6/2.1/1.4 mM for BBM/LCM/OSM). This is related to the increase in Bifidobacterium species (B. catenulatum, B. adolescentis, B. pseudocatenulatum), Coprococcus catus and Bacteroidetes members (Bacteroides caccae, Phocaeicola dorei, P. massiliensis), likely mediated via inulin. Further, the potent propionogenic potential of OSM related to increased Bacteroidetes members known to ferment oats (s key ingredient of OSM), while the butyrogenic potential of BBM related to a specific increase in Anaerobutyricum hallii, a butyrate producer specialized in the fermentation of erythritol (key ingredient of BBM). In addition, OSM/BBM suppressed the pathogen Clostridioides difficile, potentially due to inclusion of HU58™ in GoodBiome™ Foods. Finally, all products enhanced a spectrum of metabolites well beyond SCFA, including vitamins (B3/B6), essential amino acids, and health-related metabolites such as indole-3-propionic acid. Overall, the addition of specific ingredients to complex foods was shown to specifically modulate the gut microbiome, potentially contributing to health benefits. Noticeably, our findings contradict a recent in vitro study, underscoring the critical role of employing a physiologically relevant digestion/absorption procedure for a more accurate evaluation of the microbiome-modulating potential of complex foods. Full article
(This article belongs to the Special Issue Natural Metabolites on Gut Microbiome Modulation)
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Review

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12 pages, 619 KiB  
Review
From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates
by Riadh Cheddadi, Venkata Yeramilli and Colin Martin
Metabolites 2023, 13(12), 1184; https://doi.org/10.3390/metabo13121184 - 5 Dec 2023
Viewed by 2067
Abstract
The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, prompting the development of new frameworks through epidemiological studies. Traditionally, [...] Read more.
The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, prompting the development of new frameworks through epidemiological studies. Traditionally, it was believed that each individual harbored unique microbial communities acquired early in life, evolving over the course of their lifetime, with little acknowledgment of any prenatal microbial development, but recent research challenges this belief. The neonatal microbiome’s onset, influenced by factors like delivery mode and maternal health, remains a subject of intense debate, hinting at potential intrauterine microbial processes. In-depth research reveals associations between microbiome profiles and specific health outcomes, ranging from obesity to neurodevelopmental disorders. Understanding these diverse microbiome profiles is essential for unraveling the intricate relationships between the microbiome and health outcomes. Full article
(This article belongs to the Special Issue Natural Metabolites on Gut Microbiome Modulation)
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18 pages, 1346 KiB  
Review
Tryptophan Metabolism and Gut Microbiota: A Novel Regulatory Axis Integrating the Microbiome, Immunity, and Cancer
by Yingjian Hou, Jing Li and Shuhuan Ying
Metabolites 2023, 13(11), 1166; https://doi.org/10.3390/metabo13111166 - 20 Nov 2023
Cited by 27 | Viewed by 8290
Abstract
Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the host. We focused on how the gut microbiome controls tryptophan breakdown via [...] Read more.
Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the host. We focused on how the gut microbiome controls tryptophan breakdown via the indole, kynurenine, and serotonin pathways. Dysbiosis of the gut microbiota induces disruptions in tryptophan catabolism which contribute to disorders like inflammatory conditions, neuropsychiatric diseases, metabolic syndromes, and cancer. These disruptions affect immune homeostasis, neurotransmission, and gut-brain communication. Elucidating the mechanisms of microbial tryptophan modulation could enable novel therapeutic approaches like psychobiotics and microbiome-targeted dietary interventions. Overall, further research on the microbiota-tryptophan axis has the potential to revolutionize personalized diagnostics and treatments for improving human health. Full article
(This article belongs to the Special Issue Natural Metabolites on Gut Microbiome Modulation)
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