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Effect of Natural Products on Skin Diseases
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Effect of Natural Products on Skin Diseases

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 8868

Special Issue Editors

Prof. Dr. Sonia Laneri

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Montesano 49, 80131 Napoli, Italy
Interests: cosmeceuticals; natural product; skin analysis; transdermal delivery; in vivo/in vitro efficacy tests of cosmetics; analytical chemistry on natural product in cosmetics; nutricosmetics; hair analysis; innovative cosmetic formulation
Special Issues, Collections and Topics in MDPI journals
Dr. Ritamaria Di Lorenzo

E-Mail Website
Guest Editor
Department of Excellence of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: cosmetics; transdermal absorption; nutricosmetics; skin analysis; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin diseases are very common worldwide, and interest has been growing in the study of the effect of natural products on the treatment of skin disorders. Natural products have been extensively reported regarding skin disorders, exhibiting anti-inflammatory, antioxidant, anti-microbial, and anti-cancer effects as the main therapeutic actions. This Special Issue will focus in detail on new active species obtained through upcycling techniques and green chemistry, with a special focus on sustainability or the circular economy.

The aim of the present Special Issue, entitled ‘Effect of Natural Products on Skin Diseases’, is to investigate the development of natural products as a promising area for the future discovery of the drug and cosmeceutical potential of these natural lead compounds against skin disorders.

In this Special Issue, we aim to collect high-quality articles on skin diseases, natural products, and the effects of natural products on skin diseases.

Different types of contributions, such as original articles, brief communications, and reviews, on the role of natural products on skin diseases are welcome.

Prof. Dr. Sonia Laneri
Dr. Ritamaria Di Lorenzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin disease
  • natural products
  • up-cycling
  • anti-inflammatory
  • antioxidant
  • anti-microbial

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Published Papers (4 papers)

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Research

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14 pages, 6854 KiB  
Article
Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation
by Guoji Zhang, Liqin Wang, Yaxuan Qu, Shilun Mo, Xiaoying Sun and Kewei Wang
Molecules 2024, 29(16), 3728; https://doi.org/10.3390/molecules29163728 - 6 Aug 2024
Viewed by 767
Abstract
Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases. However, the molecular mechanism underlying the effects of the CA remains largely unknown. Here, we report that CA and [...] Read more.
Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases. However, the molecular mechanism underlying the effects of the CA remains largely unknown. Here, we report that CA and its two analogues, caffeic acid phenethyl ester (CAPE) and caffeic acid methyl caffeate (CAMC), inhibit TRPV3 currents in their concentration- and structure-dependent manners with IC50 values ranging from 102 to 410 μM. At the single-channel level, CA reduces the channel open probability and open frequency without alteration of unitary conductance. CA selectively inhibits TRPV3 relative to other subtypes of thermo-TRPs, such as TRPA1, TRPV1, TRPV4, and TRPM8. Molecular docking combined with site-specific mutagenesis reveals that a residue T636 in the Pore-loop is critical for CA binding to TRPV3. Further in vivo evaluation shows that CA significantly reverses TRPV3-mediated skin inflammation induced by skin sensitizer carvacrol. Altogether, our findings demonstrate that CA exerts its anti-inflammatory effects by selectively inhibiting TRPV3 through binding to the pocket formed by the Pore-loop and the S6. CA may serve as a lead for further modification and identification of specific TRPV3 channel inhibitors. Full article
(This article belongs to the Special Issue Effect of Natural Products on Skin Diseases)
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29 pages, 4920 KiB  
Article
Phytochemical and Nutraceutical Screening of Ethanol and Ethyl Acetate Phases of Romanian Galium verum Herba (Rubiaceae)
by Alexandra-Denisa Semenescu, Elena-Alina Moacă, Andrada Iftode, Cristina-Adriana Dehelean, Diana-Simona Tchiakpe-Antal, Laurian Vlase, Ana-Maria Vlase, Delia Muntean and Raul Chioibaş
Molecules 2023, 28(23), 7804; https://doi.org/10.3390/molecules28237804 - 27 Nov 2023
Cited by 5 | Viewed by 1799
Abstract
Galium species are used worldwide for their antioxidant, antibacterial, antifungal, and antiparasitic properties. Although this plant has demonstrated its antitumor properties on various types of cancer, its biological activity on cutaneous melanoma has not been established so far. Therefore, the present study was [...] Read more.
Galium species are used worldwide for their antioxidant, antibacterial, antifungal, and antiparasitic properties. Although this plant has demonstrated its antitumor properties on various types of cancer, its biological activity on cutaneous melanoma has not been established so far. Therefore, the present study was designed to investigate the phytochemical profile of two extracts of G. verum L. herba (ethanolic and ethyl acetate) as well as the biological profile (antioxidant, antimicrobial, and antitumor effects) on human skin cancer. The extracts showed similar FT-IR phenolic profiles (high chlorogenic acid, isoquercitrin, quercitrin, and rutin), with high antioxidant capacity (EC50 of ethyl acetate phase (0.074 ± 0.01 mg/mL) > ethanol phase (0.136 ± 0.03 mg/mL)). Both extracts showed antimicrobial activity, especially against Gram-positive Streptococcus pyogenes and Staphylococcus aureus bacilli strains, the ethyl acetate phase being more active. Regarding the in vitro antitumor test, the results revealed a dose-dependent cytotoxic effect against A375 melanoma cell lines, more pronounced in the case of the ethyl acetate phase. In addition, the ethyl acetate phase stimulated the proliferation of human keratinocytes (HaCaT), while this effect was not evident in the case of the ethanolic phase at 24 h post-stimulation. Consequently, G. verum l. could be considered a promising phytocompound for the antitumor approach of cutaneous melanoma. Full article
(This article belongs to the Special Issue Effect of Natural Products on Skin Diseases)
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Review

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18 pages, 1562 KiB  
Review
Pharmacological Activities of Lonicerae japonicae flos and Its Derivative—“Chrysoeriol” in Skin Diseases
by Siu Kan Law, Xiao Xiao Wu, Zhou Jiang, Christy Wing Sum Tong, Wesley Yeuk Lung Chow and Dawn Ching Tung Au
Molecules 2024, 29(9), 1972; https://doi.org/10.3390/molecules29091972 - 25 Apr 2024
Cited by 1 | Viewed by 1597
Abstract
Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) “Lonicerae japonicae flos” in the dried flower bud or bloomed flower of Lonicera japonica Thunberg. Dermatoses are the most common diseases in humans, including eczema, acne, psoriasis, moles, and [...] Read more.
Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) “Lonicerae japonicae flos” in the dried flower bud or bloomed flower of Lonicera japonica Thunberg. Dermatoses are the most common diseases in humans, including eczema, acne, psoriasis, moles, and fungal infections, which are temporary or permanent and may be painless or painful. Topical corticosteroids are widely used in Western medicine, but there are some side effects when it is continuously and regularly utilized in a large dosage. Chrysoeriol is a natural active ingredient, nontoxic, and without any adverse reactions in the treatment of dermatological conditions. Methods: Nine electronic databases were searched, including WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), without regard to language constraints. The pharmacological activities of chrysoeriol from Lonicerae japonicae flos to fight against skin diseases were explained and evaluated through the literature review of either in vitro or in vivo studies. Results: Chrysoeriol decreased the mRNA levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α. These were transcriptionally regulated by NF-κB and STAT3 to combat skin inflammation. It also showed promising actions in treating many skin ailments including wound healing, depigmentation, photoprotection, and antiaging. Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated. Full article
(This article belongs to the Special Issue Effect of Natural Products on Skin Diseases)
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34 pages, 5957 KiB  
Review
The Promising Role of Polyphenols in Skin Disorders
by Mohd Farhan
Molecules 2024, 29(4), 865; https://doi.org/10.3390/molecules29040865 - 15 Feb 2024
Cited by 6 | Viewed by 4070
Abstract
The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. The existing research suggests that plant phenolics, whether consumed orally or applied directly to the skin, can be beneficial in alleviating symptoms and avoiding the development of many skin [...] Read more.
The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. The existing research suggests that plant phenolics, whether consumed orally or applied directly to the skin, can be beneficial in alleviating symptoms and avoiding the development of many skin disorders. Phenolic compounds, which are both harmless and naturally present, exhibit significant potential in terms of counteracting the effects of skin damage, aging, diseases, wounds, and burns. Moreover, polyphenols play a preventive role and possess the ability to delay the progression of several skin disorders, ranging from small and discomforting to severe and potentially life-threatening ones. This article provides a concise overview of recent research on the potential therapeutic application of polyphenols for skin conditions. It specifically highlights studies that have investigated clinical trials and the use of polyphenol-based nanoformulations for the treatment of different skin ailments. Full article
(This article belongs to the Special Issue Effect of Natural Products on Skin Diseases)
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