Molecules, Volume 30, Issue 16

Herbs and spices are a rich source of bioactive compounds that exhibit multidirectional health-promoting effects. Their bioactivity is mainly related to the presence of phenolic acids, flavonoids, carotenoids, essential oils, alkaloids, tannins, sapo...

Exposure of LIB materials to ambient conditions with some level of humidity, either accidentally owing to imperfect fabrication or cell damage, or deliberately due to battery opening operations for analytical or recycling purposes, is a rather common...

The determination of RNA secondary structure (RSS) could help understand RNA’s functional mechanisms, guiding the design of RNA-based therapeutics, and advancing synthetic biology applications. However, traditional methods such as NMR for deter...

Applying physico-analytical methods to whole hair fibers enables investigation of hair dye performance. Light microscopy, SEM imaging and EDX mapping of intact hair fibers, as well as TEM imaging of microtome cuts, provided insights into the distribu...

In continuation of our efforts to identify novel herbicide lead compounds, twenty new 5-(1-amino-4-phenoxybutylidene)barbituric acid derivatives containing an enamino diketone motif were synthesized and evaluated for their herbicidal activities. The...

The photochemistry of 1,3,4-oxadiazoles remains poorly understood, despite their recognized importance in medicinal chemistry and materials science. In this work, we report a detailed matrix-isolation study of 2-amino-5-(4-methoxyphenyl)-1,3,4-oxadia...

Nicotine is a highly used addictive substance that has recently also become available through electronic cigarettes. Here we present a study of nicotine from e-cigarette liquids through reversed-phase (RP) and hydrophilic interaction (HILIC) liquid c...

Databases of organic compounds are rooted in chemical formats, typically modeling chemical structures as simple graphical representations, which are easily readable by both humans and machines. This information can be handled by software and standard...

A series of novel discotic liquid crystalline donor–acceptor hybrid heterojunctions were prepared by blending the triphenylene derivative (T5E36) as donor and perylene tetracarboxylic esters as acceptor. Mesophases of blends were characterized...

Nickel-catalyzed cyanation of aryl halides has emerged as a powerful and sustainable method for the synthesis of aryl nitriles—valuable motifs widely found in pharmaceuticals, agrochemicals, and functional materials. Compared to traditional cya...

Background: It has been shown previously that thienobenzo-1,2,3-triazoles exhibit very good selective inhibition toward butyrylcholinesterase (BChE), while the same derivatives converted into salts also display inhibitory activity against acetylcholi...

The consumption of animal- and plant-based protein food is increasing as the world population grows. Alternative protein sources that are nutritious, safe and sustainable are needed. There is a growing research interest in integrating wheat-based sta...

There is a growing interest in using essential oils with phytoprotectant properties instead of synthetic pesticides to mitigate the risks of insect pesticide resistance, environmental harm, and adverse effects on non-target organisms and human health...

This study systematically explored the interaction mechanisms between two KRAS G12C inhibitors (Sotorasib and Adagrasib) and human serum albumin (HSA) via UV-vis spectroscopy, fluorescence spectroscopy, three-dimensional fluorescence spectroscopy, an...

Co-combustion is regarded as an effective means for high-efficiency utilization of low-quality fuels. However, low-quality fuel has problems such as low energy density and high water content. The fuel quality and blending performance can be further o...

This study explores how intermolecular interactions govern the composition of saturated solutions of influence flufenamic acid (FlA) in deep eutectic solvents (DESs). Using choline chloride (ChCl) or menthol (Men) as the HBAs and various polyols as t...

In the context of chlorate’s application as a cathodic reagent of power sources, the mechanism of its electroreduction has been studied in electrochemical cells under diffusion-limited current conditions with operando spectrophotometric analysi...

This study explores the antioxidant potential and delivery performance of five structurally distinct cannabinoids, with a particular focus on cannabinol (CBN). Comprehensive structural characterization using mass spectrometry (MS) and nuclear magneti...

Structure–property relationships in imidazolium-based hybrid Sb(III) chlorides provide critical guidance for designing high-performance materials. Three zero-dimensional metal halides, namely, [C₃mmim]₂SbCl₅ (1, [C₃mmim]⁺ = 1-propyl-2,3-dimethy...

Bamboo, as a rapidly renewable biomass material, has garnered significant attention in contemporary research due to its cost effectiveness as a viable source for supercapacitor electrode materials. However, untreated bamboo as an electrode material o...

This paper reports on a validated, stability-indicating high-performance thin-layer chromatography (HPTLC)-based assay for the quantification of nitrofurazone in an ointment formulation. The simple and rapid HPTLC analysis was performed on silica gel...

This article presents an innovative method for phosphate(V) removal from industrial wastewater using cerium(III) chloride as a coagulant, integrated with reagent recovery. The process combines coagulation, acid extraction, and multistage recovery of...

Type 2 diabetes is a multifactorial disease characterized by chronic hyperglycemia, insulin resistance, oxidative stress, inflammation, and dyslipidemia, factors that contribute to the development of long-term complications. In this context, the 2-am...

This study reports the separation of methyl ethyl ketone (MEK), a relevant compound in the biorefinery context, from aqueous solutions using activated carbons derived from avocado seed biomass. Two synthesis routes were explored via chemical and ther...

Multi-drug resistance in human bacterial pathogens has become a significant challenge for global healthcare this century, mainly due to the widespread misuse of antibiotics worldwide. As a result, millions of people have been affected by multi-drug-r...

Guanine-rich nucleic acid sequences can adopt G-quadruplex (G4) structures, which pose barriers to DNA replication and repair. The FANCJ helicase contributes to genome stability by resolving these structures, a function linked to its G4-binding site...

Plasmid DNA (pDNA) purification plays a key role in the development of vaccines and gene therapies. Affinity chromatography stands out as a promising method for plasmid purification, leveraging a range of biological and synthetic ligands to achieve s...

Twelve undescribed peptidic compounds, bukhansantaibols A–K (1–10) and bukhansantaibals A–B (11–12), were isolated from the soil fungus Trichoderma atroviride through LC-MS and bioactivity-guided purification. Their structures...

The endohedral metallofullerenes with a rare-earth metal encapsulated into the carbon cage are nanoparticles with potentially wide applications. We present the results of our quantum-chemical modelling of Sc@${\mathrm{C}}_{60}$, Y@${\mathrm{C}}_{60}$ and Sc₂@${\mathrm{C}}_{60}$, Y₂@${\mathrm{C}}_{60}$ endofullere...

Oxidative stress, driven by excess reactive oxygen species (ROS), is a key factor in the progression of neurodegenerative diseases like Alzheimer’s disease (AD). In this context, copper dysregulation can also contribute to this imbalance, being...

This study introduces a green method for converting waste polyvinyl chloride (PVC) into hierarchical porous carbon materials. By using CaCO₃ pre-activation to capture HCl and form meso/macroporous frameworks, followed by KOH activation to tune microp...

Low-temperature plasma cleaning technology has been widely used to clean various optical components precisely. After the complete removal of organic contaminants from fused silica surfaces through plasma cleaning, continuous plasma irradiation can le...

Scandium(III) (Sc(III)) is the smallest among the trivalent ions in Group 3, which includes yttrium(III) and lanthanides (III) with a hydration number of 8 and 8–9, respectively. The hydration number of Sc(III) in aqueous solutions reported so...

Stevioside, a natural high-intensity sweetener, is widely employed across the food, pharmaceutical, and daily chemical industries due to its intense sweetness and health benefits. However, traditional extraction and purification processes for steviol...

Facial aging is a multifactorial process involving changes in bone, fat compartments, ligaments, muscles, and skin. Collagen biostimulators, including synthetic agents and autologous platelet concentrates, have gained attention for facial rejuvenatio...

The journal retracts the article entitled “Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir” [...]

The saponin-rich plant extracts are mixtures of various surface-active and non-surface-active compound substances. Their exact composition depends on the type of plant and its part from which they were extracted. In this study, we analyze the wetting...

The experimental IR and Raman vibrational spectra of a hydrated La(III) complex with a 1,2,3-triazole ligand were characterized by using four different Density Functional Theory (DFT) levels and two accurate scaling procedures. In the theoretical cal...

The study aimed to produce semolina pasta enriched with walnut or hazelnut oil cake and to investigate its nutritional and technological properties. The pasta was prepared by substituting 10% of semolina with walnut or hazelnut oil cakes. The chemica...

(1) Background: Following the discovery of the adipokine/hormone asprosin, a substantial amount of research has provided evidence for its role in the regulation of glucose homeostasis, as well as appetite, and insulin sensitivity. Its levels are dysr...

Despite the widespread use of vaccines against SARS-CoV-2, COVID-19 continues to pose global health challenges, requiring efficient drug screening and repurposing strategies. This study presents a novel hybrid framework that integrates deep learning...

Climate change has led to increased extreme weather events, such as severe droughts and intense rainfall, with regions in Portugal, like Alentejo and Algarve, being particularly affected. Understanding the influence of water availability in the conce...

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by a clinical and/or biochemical hyperandrogenism. In addition, PCOS is also associated with the presence of ovarian cysts, anovulation, and menstrual abnormalities...

The design of photocatalysts capable of generating localized surface plasmon resonance (LSPR) effects represents a promising strategy for enhancing photocatalytic activity. However, the mechanistic role of plasmonic nanoparticles-induced interfacial...

This short review provides a focused overview of recent advances in catalytic systems for water purification, with particular attention to photocatalysis, Fenton-like processes, and biocatalysis. While not intended as a comprehensive survey, this rev...

Phase change absorbents are deemed a promising alternative for CO₂ capture due to their excellent CO₂ absorption performance, good stability, and low renewable energy consumption. To address the issues of insufficient loading capacity, low regenerati...

In the quest for greener alternatives to conventional organic solvents, Deep Eutectic Solvents (DESs) have gained significant attention due to their sustainability, biodegradability, and tunability. The use of water as an active and genuine component...

Proteolysis-targeting chimera (PROTAC) technology has demonstrated remarkable progress in tumor therapy, attributed to its unique capability of catalytically degrading “undruggable” targets. In the context of the ongoing global health thr...

The escalating crisis of multidrug resistance, together with the persistence of antibiotic residues in clinical and environmental matrices, demands integrated strategies that couple sensitive detection, efficient decontamination, and controlled deliv...

To discover novel, potent anticonvulsant compounds, a series of compounds containing triazole structural fragments were synthesized and evaluated for their anticonvulsant activity. Compounds 6f (maximal electroshock (MES), 50% effective dose (ED₅₀) =...