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Nutrients
Special Issues
Recent Advances in Gluten-Free Diet and Celiac Disease
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Recent Advances in Gluten-Free Diet and Celiac Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 4703

Special Issue Editors

Prof. Dr. Carlo Catassi

E-Mail Website
Guest Editor
Division of Pediatrics, DISCO Department, Polytechnic University of Marche, 60123 Ancona, Italy
Interests: celiac disease and other gluten-related disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fernando Chirdo

E-Mail Website1 Website2
Guest Editor
Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Instituto de Estudios Inmunologicos y Fisiopatologicos—IIFP (UNLP-CONICET), Bv. 120 1489, La Plata 1900, Argentina
Interests: celiac disease; experimental enteropathy; inflammation

Special Issue Information

Dear Colleagues,

Thanks to the pioneering work of the Dutch pediatrician Willem Dicke in the 1950s, the gluten-free diet (GFD) has become the standard therapy for celiac disease (CeD), one of the most common life-long disorders. Through this simple and straightforward dietary treatment, thousands of lives have been saved and millions of patients have been able to live healthy lives. Recently, it has been discovered that the GFD can treat other gluten-related disorders (GRD), such as gluten ataxia and non-celiac gluten sensitivity. Nevertheless, the GFD has limitations, such as a less-than-optimal content of nutrients such as fiber and calcium, the risk of gluten contamination in many commercial foods, and a significant impact on the psycho-social aspects of daily life. As such, alternative/complementary dietary and non-dietary treatments are currently under scrutiny.

The aim of this Special Issue of Nutrients is to highlight recent advances in the gluten-free diet in CeD and other GRDs from a broad perspective, e.g., including new methods for gluten analysis, the clinical monitoring of adherence to the GFD, psycho-social quality of life in patients treated with the GFD, complementary/alternative treatments including gluten-free wheat flours, probiotics and drugs.

Prof. Dr. Carlo Catassi
Prof. Dr. Fernando Chirdo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • celiac disease
  • gluten-related disorders
  • gluten-free diet
  • wheat-related disorders
  • gluten
  • dietary treatment
  • adherence to the gluten-free diet

Published Papers (3 papers)

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Research

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14 pages, 280 KiB  
Article
Division of Responsibility in Child Feeding and Eating Competence: A Cross-Sectional Study in a Sample of Caregivers of Brazilian Children with Celiac Disease
by Larissa Caetano Silva, Eduardo Yoshio Nakano and Renata Puppin Zandonadi
Nutrients 2024, 16(7), 1052; https://doi.org/10.3390/nu16071052 - 04 Apr 2024
Viewed by 544
Abstract
The objective of this cross-sectional study was to assess eating competence (EC) and the adherence to the division of responsibility in child feeding (sDOR) of Brazilian caregivers of children with celiac disease (CD). It also examined the association between EC and sDOR, children’s [...] Read more.
The objective of this cross-sectional study was to assess eating competence (EC) and the adherence to the division of responsibility in child feeding (sDOR) of Brazilian caregivers of children with celiac disease (CD). It also examined the association between EC and sDOR, children’s adherence to a gluten-free diet, and sociodemographic data. This study administered a survey set that included sociodemographic data, health-related data, eating habits, and the instruments ecSI2.0TMBR and sDOR.2-6yTM BR, validated for a Brazilian population. The sample comprised 50 caregivers of children with CD (between 24 and 72 months of age). The participants following a gluten-free diet (GFD) presented higher scores for all EC domains and the total EC. The total EC scores were higher for the participants over 40 y/o, frequently having meals as a family, with their children consuming more than three servings of fruit and at least one serving of vegetables daily and complying with a GFD. Different from the EC, the sDOR.2-6yTM scores did not differ between the participants complying with a GFD. The sDOR.2-6yTM mealtime structure domain scores were significantly associated with the EC eating attitude, food acceptance, contextual skills, and total. These findings support the need for greater attention to exploring the division of responsibility in feeding and EC in pediatric celiac disease, potentially enhancing intervention strategies for patients and their families. Full article
(This article belongs to the Special Issue Recent Advances in Gluten-Free Diet and Celiac Disease)

Review

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15 pages, 290 KiB  
Review
Gluten and Wheat in Women’s Health: Beyond the Gut
by Francesca Manza, Lisa Lungaro, Anna Costanzini, Fabio Caputo, Umberto Volta, Roberto De Giorgio and Giacomo Caio
Nutrients 2024, 16(2), 322; https://doi.org/10.3390/nu16020322 - 22 Jan 2024
Viewed by 2405
Abstract
Since the rise of awareness of gluten/wheat-related disorders in the academic and clinical field in the last few decades, misinformation regarding the gluten-free diet (GFD) and its impact on health has been spreading among the general population. Despite the established link between gluten [...] Read more.
Since the rise of awareness of gluten/wheat-related disorders in the academic and clinical field in the last few decades, misinformation regarding the gluten-free diet (GFD) and its impact on health has been spreading among the general population. Despite the established link between gluten and celiac disease (CD), where a GFD is mandatory to reach clinical and histological remission, things are more complicated when it comes to non-celiac gluten/wheat sensitivity (NCGWS) and other autoimmune/dysimmune disorders. In the last conditions, a beneficial effect of gluten withdrawal has not been properly assessed, but still is often suggested without strong supporting evidence. In this context, women have always been exposed, more than men, to higher social pressure related to nutritional behaviors and greater engagement in controlling body weight. With this narrative review, we aim to summarize current evidence on the adherence to a GFD, with particular attention to the impact on women’s health. Full article
(This article belongs to the Special Issue Recent Advances in Gluten-Free Diet and Celiac Disease)

Other

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8 pages, 1028 KiB  
Brief Report
Dynamics of Serologic Change to Gluten in Celiac Disease Patients
by Jack Syage, Ana Ramos, Vasiliy Loskutov, Anna Norum, Adam Bledsoe, Rok Seon Choung, Matthew Dickason, Jennifer Sealey-Voyksner and Joseph Murray
Nutrients 2023, 15(24), 5083; https://doi.org/10.3390/nu15245083 - 12 Dec 2023
Viewed by 1108
Abstract
Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA and immunoglobulin G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) and for monitoring adherence to a gluten-free diet (GFD), currently the only available [...] Read more.
Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA and immunoglobulin G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) and for monitoring adherence to a gluten-free diet (GFD), currently the only available treatment for CeD. We address two issues in this study: (i) the relapse to seropositivity for CeD patients who resume a gluten containing diet and (ii) the correlation between two different tTG-IgA assays near the upper limit of normal (ULN) designated thresholds. Regarding the first issue, often a suspected CeD individual is put back on a gluten diet to return to their serologic levels. However, we show it requires a substantial amount of gluten for serology to return to a positive level. For example, in one study of 22 patients treated with placebo and taking 84 g of gluten over 6 weeks, only two converted from seronegative to seropositive for tTG-IgA. Regarding the second topic, we compare the relationship for different serologic assays, namely tTG-IgA AB (recombinant, ULN = 4 units/mL) vs. tTG-IgA (non-recombinant, ULN = 20 units). There is a strong correlation between both measurements as evidenced by a Pearson coefficient of R = 0.8584; however, we observed that the cross-correlation in terms of sensitivity and specificity improved substantially by using an ULN value of three instead of four for the tTG-IgA AB (recombinant) assay. This result suggests that assay thresholds used for initial diagnosis in patients who have not yet started a GFD may need to be adjusted for monitoring and in the setting of a diagnostic gluten challenge. Full article
(This article belongs to the Special Issue Recent Advances in Gluten-Free Diet and Celiac Disease)
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