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Nutrients
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Dietary Guidance and Nutritional Support to Inflammatory Bowel Disease
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Dietary Guidance and Nutritional Support to Inflammatory Bowel Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 15 February 2025 | Viewed by 1084

Special Issue Editor

Prof. Dr. Roberto Castiglione

E-Mail Website
Guest Editor
1. Department of Medical, Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, 95123 Catania, Italy
2. Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
Interests: inflammatory bowel disease; andrology; infertility; cytokines; the gut microbiota; epidemiology; nutraceutical polyphenols; micronutrients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that underlies several related diseases. Currently, there is no cure for IBD, and available treatment approaches target reducing inflammation for unspecified periods. An alteration of the gastrointestinal microbiota through dietary therapy was found to reduce IBD and is recognized as a promising therapeutic strategy for IBD. One of the recommended formulated diets is an anti-inflammatory diet (AID) that restricts the intake of carbohydrates with modified fatty acids. This diet also contains probiotics and prebiotics that can promote a balanced intestinal microbiota composition. The aim of this Special Issue on “Dietary Guidance and Nutritional Support to Inflammatory Bowel Disease” is to evaluate the AID diet’s effectiveness, which will be useful for clinicians to manage their IBD patients through the application of improved dietary therapy.

This Special Issue welcomes contributions of articles related to this topic; recommended reviews and original articles, brief reports, and communications are also welcome.

Prof. Dr. Roberto Castiglione
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-inflammatory diet
  • inflammatory bowel disease
  • nutritional intake
  • prebiotics
  • probiotics

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Published Papers (1 paper)

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Review

16 pages, 1058 KiB  
Review
Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Crohn’s Disease
by Ramasatyaveni Geesala, Pratik Gongloor, Neeraja Recharla and Xuan-Zheng Shi
Nutrients 2024, 16(21), 3581; https://doi.org/10.3390/nu16213581 - 22 Oct 2024
Viewed by 935
Abstract
Background and Objectives: Crohn’s disease (CD) is an inflammatory bowel disease (IBD) characterized by transmural inflammation and intestinal fibrosis involving mostly the small intestine and colon. The pathogenic mechanisms of CD remain incompletely understood and cures are unavailable. Current medical therapies are aimed [...] Read more.
Background and Objectives: Crohn’s disease (CD) is an inflammatory bowel disease (IBD) characterized by transmural inflammation and intestinal fibrosis involving mostly the small intestine and colon. The pathogenic mechanisms of CD remain incompletely understood and cures are unavailable. Current medical therapies are aimed at inducing prolonged remission. Most of the medical therapies such as corticosteroids have substantial adverse effects. Consequently, many dietary therapies have been explored for the management of CD. Up to now, exclusive enteral nutrition (EEN) has been considered the only established dietary treatment for IBD, especially CD. In this article, we aim to give a concise review about the current therapeutic options and challenges in the management of CD and aim to compare the efficacy of EEN with other dietary therapies and update on the possible mechanisms of the benefits of EEN and other nutritional therapies. Methods: We searched the literature up to August 2024 through PubMed, Web of Science, and other sources using search terms such as EEN, nutritional therapy, IBD, Crohn’s disease, ulcerative colitis. Clinical studies in patients and preclinical studies in rodent models of IBD were included in the summary of the therapeutic benefits. Results and Conclusions: EEN involves oral or nasogastric tube feeding of a complete liquid diet with exclusion of normal foods for a defined period (usually 6 to 8 weeks). EEN treatment is demonstrated to have anti-inflammatory and healing effects in CD through various potential pathways, including altering gut bacteria and their metabolites, restoring the barrier function, direct anti-inflammatory action, and indirect anti-inflammatory action by eliminating mechanical stress in the bowel. However, efficacy of other nutritional therapies is not well established in CD, and mechanisms of action are largely unknown. Full article
(This article belongs to the Special Issue Dietary Guidance and Nutritional Support to Inflammatory Bowel Disease)
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