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Nitrogen Nutrition and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 497

Special Issue Editor

Department of Nutrition and Food Hygiene, Peking University Health and Science Center, Beijing, China
Interests: nitrogen source nutrition; bioactive oligopeptide; dietary nucleotide; geriatric nutrition; food toxicology; metabolic disorder; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

“Nitrogen Nutrition and Human Health” has garnered significant interest worldwide. The concentration of protein, nucleic acid, and vitamin B groups, and nitrogen in food plays a central role in human nutrition. In recent years, with the rapid development of food science and technology and nutrition research, the physiological functions of food active substances containing nitrogen, such as bioactive oligopeptides, dietary nucleotides and their derivatives (e.g., nicotinamide mononucleotide), have been gradually revealed.

The identification and quantification of active compounds are of immense value for revealing their functions. The development of omics technology and analytical chemistry has provided us with powerful tools to further understand nitrogen components and makes it possible to discover, analyze, and identify food composition and biomarkers; it also enables us to explain the mechanism between internal and external exposure in humans. This Special Issue aims to present high-quality research on nitrogen nutrition so that a more comprehensive understanding of its effects on human health can be obtained. Because we still cannot fully comprehend the intricate relationship between nitrogen nutrition and human health, the latest advances in our understanding of “nitrogen nutrition” will be presented. We welcome manuscripts from the following subtopics:

  • Identification and quantification of nitrogen in food, especially using omics;
  • Demonstration of the molecular mechanisms of nitrogen substances (such as bioactive oligopeptides, exogenous nucleotides) exhibiting health functions in vivo and in vitro;
  • The investigation of metabolism and bioactivities of nitrogen substances by using clinical trials;
  • Effects of nitrogen substance on chronic diseases, and the mechanism;
  • Nitrogen substance-derived functional foods.

Dr. Meihong Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nitrogen
  • bioactive oligopeptidex
  • dietary nucleotide
  • geriatric nutrition
  • metabolic disorder

Published Papers (1 paper)

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Research

17 pages, 4883 KiB  
Article
Exogenous Nucleotides Improve the Skin Aging of SAMP8 Mice by Modulating Autophagy through MAPKs and AMPK Pathways
by Rui Fan, Ying Zhang, Rui Liu, Chan Wei, Xiujuan Wang, Xin Wu, Xiaochen Yu, Zhen Li, Ruixue Mao, Jiani Hu, Na Zhu, Xinran Liu, Yong Li and Meihong Xu
Nutrients 2024, 16(12), 1907; https://doi.org/10.3390/nu16121907 - 17 Jun 2024
Viewed by 392
Abstract
The skin, serving as the body’s primary defense against external elements, plays a crucial role in protecting the body from infections and injuries, as well as maintaining overall homeostasis. Skin aging, a common manifestation of the aging process, involves the gradual deterioration of [...] Read more.
The skin, serving as the body’s primary defense against external elements, plays a crucial role in protecting the body from infections and injuries, as well as maintaining overall homeostasis. Skin aging, a common manifestation of the aging process, involves the gradual deterioration of its normal structure and repair mechanisms. Addressing the issue of skin aging is increasingly imperative. Multiple pieces of evidence indicate the potential anti-aging effects of exogenous nucleotides (NTs) through their ability to inhibit oxidative stress and inflammation. This study aims to investigate whether exogenous NTs can slow down skin aging and elucidate the underlying mechanisms. To achieve this objective, senescence-accelerated mouse prone-8 (SAMP8) mice were utilized and randomly allocated into Aging, NTs-low, NTs-middle, and NTs-high groups, while senescence-accelerated mouse resistant 1 (SAMR1) mice were employed as the control group. After 9 months of NT intervention, dorsal skin samples were collected to analyze the pathology and assess the presence and expression of substances related to the aging process. The findings indicated that a high-dose NT treatment led to a significant increase in the thickness of the epithelium and dermal layers, as well as Hyp content (p < 0.05). Additionally, it was observed that low-dose NT intervention resulted in improved aging, as evidenced by a significant decrease in p16 expression (p < 0.05). Importantly, the administration of high doses of NTs could improve, in some ways, mitochondrial function, which is known to reduce oxidative stress and promote ATP and NAD+ production significantly. These observed effects may be linked to NT-induced autophagy, as evidenced by the decreased expression of p62 and increased expression of LC3BI/II in the intervention groups. Furthermore, NTs were found to upregulate pAMPK and PGC-1α expression while inhibiting the phosphorylation of p38MAPK, JNK, and ERK, suggesting that autophagy may be regulated through the AMPK and MAPK pathways. Therefore, the potential induction of autophagy by NTs may offer benefits in addressing skin aging through the activation of the AMPK pathway and the inhibition of the MAPK pathway. Full article
(This article belongs to the Special Issue Nitrogen Nutrition and Human Health)
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