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Nutrients
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Dietary Natural Products and Inflammation
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Dietary Natural Products and Inflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 1634

Special Issue Editor

Dr. Anna Olejnik

E-Mail Website
Guest Editor
Department of Biotechnology and Food Microbiology, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland
Interests: functional foods; dietary bioactive compounds; nutrigenomics; antioxidant activity; anticancer potential; chemoprevention; anti-inflammatory effects; obesity; inflammatory bowel disease; endometriosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Much scientific evidence points out strong correlations between inflammation and overall health and between the incidence of inflammation and disease progression and prognosis. Inflammation is involved in the pathogenesis of many chronic diseases, such as cardiovascular and bowel diseases, diabetes, arthritis, obesity, endometriosis, and cancer.

The scientific community has recognized the importance of natural bioactive compounds and dietary products with proven capabilities to reduce or reverse inflammation in preventing and treating inflammatory diseases. Anti-inflammatory nutritional intervention is believed to encompass great potential in the treatment of inflammatory-related disorders. Therefore, this Special Issue is devoted to collecting the newest research findings from clinical trials and preclinical in vitro and in vivo studies on the anti-inflammatory effects of natural dietary ingredients and discussing their potential application in nutritional recommendations for patients with inflammatory diseases.

Publicly available articles from this collection will enable the dissemination of the latest research results among researchers, clinical dietitians, and patients.

Dr. Anna Olejnik
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive dietary compounds
  • functional foods
  • inflammation
  • inflammatory-related disease
  • inflammatory bowel disease
  • cancer
  • obesity
  • diabetes
  • cardiovascular diseases
  • allergy
  • anti-inflammatory potential
  • antioxidant capacity
  • inflammatory cytokines and mediators

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Published Papers (2 papers)

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Research

22 pages, 13426 KiB  
Article
Resveratrol and Its Natural Analogs Mitigate Immune Dysregulation and Oxidative Imbalance in the Endometriosis Niche Simulated in a Co-Culture System of Endometriotic Cells and Macrophages
by Agata Gołąbek-Grenda, Wojciech Juzwa, Mariusz Kaczmarek and Anna Olejnik
Nutrients 2024, 16(20), 3483; https://doi.org/10.3390/nu16203483 (registering DOI) - 14 Oct 2024
Viewed by 331
Abstract
Background: Inflammation and immune cell dysfunction are critical facilitators of endometriosis pathophysiology. Macrophages are renowned for stimulating lesion growth, vascularization, innervation, and pain generation. By combining macrophages and endometriotic cells, we determined if resveratrol and its natural analogs can target the immune dysregulation [...] Read more.
Background: Inflammation and immune cell dysfunction are critical facilitators of endometriosis pathophysiology. Macrophages are renowned for stimulating lesion growth, vascularization, innervation, and pain generation. By combining macrophages and endometriotic cells, we determined if resveratrol and its natural analogs can target the immune dysregulation and oxidative imbalance in endometriosis. Methods: After treatment with compounds (5, 10, 25 µM), we evaluated the expression of key inflammatory and oxidative stress markers, cytokines release, and ROS production by applying q-PCR, ELISA, Cytometric Beads Array, and multiplexed fluorogenic staining and flow cytometry analysis with bioimaging. Results: The results showed that endometriosis-related macrophages treated with stilbenes have impaired expression of pro-inflammatory markers (IL6, IL8, IL1B, TNF, CCL2, CXCL10, PTGS2). The effect of resveratrol, pterostilbene, and piceatannol was observed, especially in reducing IL1B, CCL2, and CXCL10 genes up to 3.5-, 5-, and 7.7-fold at 25 µM, respectively. Also, with piceatannol or polydatin exposure, the IL-6 decrease was noticeable. This study reported an antioxidant effect by reducing ROS-positive cells from 96% to 48% by pterostilbene. Results from flow cytometry correlated with the transcript activation of detoxification enzymes (SOD, GPX). Conclusions: Prospects for potential therapy based on regulating the immune microenvironment and reducing the accumulation of free radicals with stilbenes application were described in the article. Full article
(This article belongs to the Special Issue Dietary Natural Products and Inflammation)
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17 pages, 793 KiB  
Article
Dairy Consumption and Inflammatory Bowel Disease among Arab Adults: A Case–Control Study and Meta-Analysis
by Anas M. Almofarreh, Haytham A. Sheerah, Ahmed Arafa, Ahmed S. Al Mubarak, Aidrous M. Ali, Nasser M. Al-Otaibi, Mohammed A. Alzahrani, Atif R. Aljubayl, Mohammad A. Aleid and Suliman S. Alhamed
Nutrients 2024, 16(16), 2747; https://doi.org/10.3390/nu16162747 - 17 Aug 2024
Viewed by 941
Abstract
Background: Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a complex disease with increasing global incidence and prevalence. Although dairy consumption has been linked to various chronic diseases, its relationship with IBD remains uncertain. Additionally, there is [...] Read more.
Background: Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a complex disease with increasing global incidence and prevalence. Although dairy consumption has been linked to various chronic diseases, its relationship with IBD remains uncertain. Additionally, there is a lack of data on this topic from Arab countries. This study aimed to investigate the association between dairy consumption and IBD through a case–control study among Arab populations, followed by a meta-analysis of available studies. Method: First, we used data from 158 UC patients, 244 CD patients, and 395 controls attending a polyclinic in Riyadh, Saudi Arabia. All participants were aged ≥ 18 years. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) of UC and CD for individuals who reported the highest versus the lowest frequencies of dairy consumption. Next, we conducted a meta-analysis, combining our results with those from other eligible studies after searching several databases. We used the I2 statistics to examine statistical heterogeneity across studies and the regression test for funnel plot asymmetry to assess publication bias. Results: The case–control study showed a negative association between frequent dairy consumption and UC (OR (95% CI) = 0.64 (0.41, 1.00)) but not CD (OR (95% CI) = 0.97 (0.65, 1.45)). In the meta-analysis, the highest frequencies of dairy consumption were negatively associated with both UC and CD: ORs (95% CIs) = 0.82 (0.68, 0.98) and 0.72 (0.59, 0.87), respectively. A moderate heterogeneity across studies was noticed in the UC meta-analysis (I2 = 59.58%) and the CD meta-analysis (I2 = 41.16%). No publication bias was detected. Conclusions: Frequent dairy consumption could protect against the development of UC and CD, suggesting potential dietary recommendations in the context of IBD prevention. Full article
(This article belongs to the Special Issue Dietary Natural Products and Inflammation)
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