Nutrients

24 pages, 5222 KiB

Open AccessArticle

Iron Deficiency: Global Trends and Projections from 1990 to 2050

by Li Wang, Dan Liang, Hengqian Huangfu, Xinfu Shi, Shuang Liu, Panpan Zhong, Zhen Luo, Changwen Ke and Yingsi Lai

Nutrients 2024, 16(20), 3434; https://doi.org/10.3390/nu16203434 (registering DOI) - 10 Oct 2024

Abstract

Background: Iron deficiency (ID) remains the leading cause of anemia, affects a vast number of persons globally, and continues to be a significant global health burden. Comprehending the patterns of ID burden is essential for developing targeted public health policies. Methods: Using data [...] Read more.

Background: Iron deficiency (ID) remains the leading cause of anemia, affects a vast number of persons globally, and continues to be a significant global health burden. Comprehending the patterns of ID burden is essential for developing targeted public health policies. Methods: Using data from the Global Burden of Disease (GBD) 2021 study for the years 1990–2021, the XGBoost model was constructed to predict prevalence and disability-adjusted life years (DALYs) for the period 2022–2050, based on key demographic variables. Shapley Additive exPlanations (SHAP) values were applied to interpret the contributions of each variable to the model’s predictions. Additionally, the Age–Period–Cohort (APC) model was used to evaluate the effects of age, period, and birth cohort on both prevalence and DALYs. The relationship between the Socio-Demographic Index (SDI) and ID’s age-standardized prevalence rate (ASPR) as well as the age-standardized DALYs rate (ASDR) was also analyzed to assess the influence of socioeconomic development on disease burden. Results: The global prevalent cases of ID grew from 984.61 million in 1990 to 1270.64 million in 2021 and are projected to reach 1439.99 million by 2050. Similarly, global DALYs from ID increased from 28.41 million in 1990 to 32.32 million in 2021, with a projected rise to 36.13 million by 2050. The ASPR declined from 18,204/100,000 in 1990 to 16,433/100,000 in 2021, with an estimated annual percentage change (EAPC) of −0.36% over this period. It is expected to decrease further to 15,922 by 2050, with an EAPC of −0.09% between 2021 and 2050. The ASDR was 518/100,000 in 1990 and 424/100,000 in 2021, with an EAPC of −0.68% from 1990 to 2021. It is expected to remain relatively stable at 419/100,000 by 2050, with an EAPC of −0.02% between 2021 and 2050. In 2021, the highest ASPRs were recorded in Senegal (34,421/100,000), Mali (34,233/100,000), and Pakistan (33,942/100,000). By 2050, Mali (35,070/100,000), Senegal (34,132/100,000), and Zambia (33,149/100,000) are projected to lead. For ASDR, Yemen (1405/100,000), Mozambique (1149/100,000), and Mali (1093/100,000) had the highest rates in 2021. By 2050, Yemen (1388/100,000), Mali (1181/100,000), and Mozambique (1177/100,000) are expected to remain the highest. SHAP values demonstrated that gender was the leading predictor of ID, with age and year showing negative contributions. Females aged 10 to 60 consistently showed higher prevalence and DALYs rates compared to males, with the under-5 age group having the highest rates for both. Additionally, men aged 80 and above exhibited a rapid increase in prevalence. Furthermore, the ASPR and ASDR were significantly higher in regions with a lower SDI, highlighting the greater burden of ID in less developed regions. Conclusions: ID remains a significant global health concern, with its burden projected to persist through 2050, particularly in lower-SDI regions. Despite declines in ASPR and ASDR, total cases and DALYs are expected to rise. SHAP analysis revealed that gender had the greatest influence on the model’s predictions, while both age and year showed overall negative contributions to ID risk. Children under 5, women under 60, and elderly men aged 80+ were the most vulnerable groups. These findings underscore the need for targeted interventions, such as improved nutrition, early screening, and addressing socioeconomic drivers through iron supplementation programs in low-SDI regions. Full article

(This article belongs to the Section Micronutrients and Human Health)

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13 pages, 497 KiB

Open AccessArticle

Complementary Role of BMI and EOSS in Predicting All-Cause and Cause-Specific Mortality in People with Overweight and Obesity

by Fabio Bioletto, Valentina Ponzo, Ilaria Goitre, Beatrice Stella, Farnaz Rahimi, Mirko Parasiliti-Caprino, Fabio Broglio, Ezio Ghigo and Simona Bo

Nutrients 2024, 16(20), 3433; https://doi.org/10.3390/nu16203433 (registering DOI) - 10 Oct 2024

Abstract

Objective: To assess the complementary role of the Body Mass Index (BMI) and Edmonton Obesity Staging System (EOSS) in predicting all-cause and cause-specific mortality in people living with overweight and obesity (PLwOW/O). Methods: A longitudinal analysis of prospectively collected data from the 1999–2018 [...] Read more.

Objective: To assess the complementary role of the Body Mass Index (BMI) and Edmonton Obesity Staging System (EOSS) in predicting all-cause and cause-specific mortality in people living with overweight and obesity (PLwOW/O). Methods: A longitudinal analysis of prospectively collected data from the 1999–2018 cycles of the National Health and Nutrition Examination Survey (NHANES) was conducted. The association between BMI, EOSS, and mortality was evaluated through Cox regression models, adjusted for confounders. Results: The analysis included 36,529 subjects; 5329 deaths occurred over a median follow-up of 9.1 years (range: 0–20.8). An increased mortality risk was observed for obesity class II and III (HR = 1.21, 95% CI 1.08–1.36, p = 0.001 and HR = 1.58, 95% CI 1.39–1.80, p < 0.001; compared to overweight), and for EOSS stage 2 and 3 (HR = 1.36, 95% CI 1.16–1.58, p < 0.001 and HR = 2.66, 95% CI 2.26–3.14, p < 0.001; compared to stage 0/1). The prognostic role of BMI was more pronounced in younger patients, males, and non-Black individuals, while that of EOSS was stronger in women. Both BMI and EOSS independently predicted cardiovascular- and diabetes-related mortality. EOSS stage 3 was the only predictor of death from malignancy or renal causes. Conclusions: BMI and EOSS independently predict all-cause and cause-specific mortality in PLwOW/O. Their integrated use seems advisable to best define the obesity-related mortality risk. Full article

(This article belongs to the Section Nutrition and Obesity)

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5 pages, 192 KiB

Open AccessEditorial

The Role of Bioactive Compounds in Immunonutrition

by Fernando Rivero-Pino and Sergio Montserrat-de la Paz

Nutrients 2024, 16(20), 3432; https://doi.org/10.3390/nu16203432 (registering DOI) - 10 Oct 2024

Abstract

The link between diet and immune function is a growing area of interest, recognized not only by the scientific community but also by global health organizations, such as the World Health Organization (WHO) [...] Full article

(This article belongs to the Special Issue The Role of Bioactive Compounds in Immunonutrition)

32 pages, 1236 KiB

Open AccessReview

The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review

by Virginia Boccardi, Luca Tagliafico, Angelica Persia, Elena Page, Silvia Ottaviani, Anna Laura Cremonini, Consuelo Borgarelli, Livia Pisciotta, Patrizia Mecocci, Alessio Nencioni and Fiammetta Monacelli

Nutrients 2024, 16(20), 3431; https://doi.org/10.3390/nu16203431 (registering DOI) - 10 Oct 2024

Abstract

Background: The aging population is associated with a net increase in the incidence and prevalence of chronic-degenerative diseases, particularly neurocognitive disorders. Therefore, the identification of preventative strategies to restrain the burden of such chronic conditions is of key relevance. Red wine and its [...] Read more.

Background: The aging population is associated with a net increase in the incidence and prevalence of chronic-degenerative diseases, particularly neurocognitive disorders. Therefore, the identification of preventative strategies to restrain the burden of such chronic conditions is of key relevance. Red wine and its components have accumulated evidence regarding their positive effects in terms of neurological pathologies associated with neurocognitive symptoms. Methods: Based on this background, the present narrative review aims to summarize the state-of-the-art evidence on the effects of red wine and its components on neurocognitive disorders in both preclinical and clinical settings. Results: The main findings highlight a protective effect of wine polyphenols present in red wine on dementia in different preclinical models of cognitive decline. The current translational clinical evidence remains uncertain, especially considering the risk-to-benefit ratio of alcohol consumption on brain health. Conclusions: Given the overall health risks associated with red wine consumption and consistent with the prevailing guidelines in the literature, there is insufficient evidence to support light-to-moderate red wine consumption as an effective strategy for preventing these diseases. However, the largely preclinical findings on polyphenols derived from red wine remain of significant interest in this context. Full article

(This article belongs to the Special Issue Diet, Lifestyle and Cognition)

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21 pages, 6048 KiB

Open AccessArticle

Enhanced Effect of β-Lactoglobulin Immunization in Mice with Mild Intestinal Deterioration Caused by Low-Dose Dextran Sulphate Sodium: A New Experimental Approach to Allergy Studies

by Dagmara Złotkowska, Lidia Hanna Markiewicz, Anna Maria Ogrodowczyk, Barbara Wróblewska and Ewa Wasilewska

Nutrients 2024, 16(20), 3430; https://doi.org/10.3390/nu16203430 (registering DOI) - 10 Oct 2024

Abstract

Background/Objectives: Cow’s milk allergy is one of the most common food allergies in children, and its pathomechanism is still under investigation. Recently, an increasing number of studies have linked food allergy to intestinal barrier dysfunction. The present study aimed to investigate changes in [...] Read more.

Background/Objectives: Cow’s milk allergy is one of the most common food allergies in children, and its pathomechanism is still under investigation. Recently, an increasing number of studies have linked food allergy to intestinal barrier dysfunction. The present study aimed to investigate changes in the intestinal microenvironment during the development of β-lactoglobulin (β-lg) allergy under conditions of early intestinal dysfunction. Methods: BALB/c mice received intraperitoneal β-lg with Freund’s adjuvant, followed by oral β-lg while receiving dextran sulphate sodium salt (DSS) in their drinking water (0.2% w/v). The immunized group without DSS and the groups receiving saline, oral β-lg, or DSS served as controls. Results: The study showed that the immunization effect was greater in mice with mild intestinal barrier dysfunction. Although DSS did not affect the mice’s humoral response to β-lg, in combination with β-lg, it significantly altered their cellular response, affecting the induction and distribution of T cells in the inductive and peripheral tissues and the activation of immune mediators. Administration of β-lg to sensitized mice receiving DSS increased disease activity index (DAI) scores and pro-inflammatory cytokine activity, altered the distribution of claudins and zonulin 1 (ZO-1) in the colonic tissue, and negatively affected the balance and activity of the gut microbiota. Conclusions: The research model used appears attractive for studying food allergen sensitization, particularly in relation to the initial events leading to mucosal inflammation and the development of food hypersensitivity. Full article

(This article belongs to the Special Issue Relationship Between Food Allergy and Human Health)

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20 pages, 4006 KiB

Open AccessArticle

Feasibility of Employing mHealth in Delivering Preventive Nutrition Interventions Targeting the First 1000 Days of Life: Experiences from a Community-Based Cluster Randomised Trial in Rural Bangladesh

by Tarana E Ferdous, Md. Jahiduj Jaman, Abu Bakkar Siddique, Nadia Sultana, Takrib Hossain, Shams El Arifeen and Sk Masum Billah

Nutrients 2024, 16(20), 3429; https://doi.org/10.3390/nu16203429 (registering DOI) - 10 Oct 2024

Abstract

Background/Objectives: An Android platform-based customised app and web-linked system was developed to aid in implementing selected nutrition interventions by community health workers (CHWs) in a community-based cluster randomised trial (c-RCT) in rural Bangladesh. Methods: Here, we describe the architecture of the intervention delivery [...] Read more.

Background/Objectives: An Android platform-based customised app and web-linked system was developed to aid in implementing selected nutrition interventions by community health workers (CHWs) in a community-based cluster randomised trial (c-RCT) in rural Bangladesh. Methods: Here, we describe the architecture of the intervention delivery system, and explore feasibility of employing mHealth as CHWs’ job aid, employing a mixed-method study design covering 17 visits per mother-child dyad. We analysed CHWs’ real-time visit information from monitoring and documentation data, and CHWs’ qualitative interviews to explore the advantages and barriers of using mHealth as a job aid. Results: Intervention coverage was high across the arms (>90%), except around the narrow perinatal period (51%) due to mothers’ cultural practice of moving to their parents’ homes and/or hospitals for childbirth. CHWs mentioned technical and functional advantages of the job aid including device portability, easy navigability of content, pictorial demonstration that improved communication, easy information entry, and automated daily scheduling of tasks. Technical challenges included charging tablets, especially in power cut-prone areas, deteriorated battery capacity over continuous device usage, unstable internet network in unsupportive weather conditions, and device safety. Nevertheless, onsite supervision and monitoring by expert supervisors remained important to ensure intervention quality. Conclusions: With appropriate training and supervision, CHWs utilised the tablet-based app proficiently, attaining high coverage of long-term visits. mHealth was thus useful for designing, planning, scheduling, and delivering nutrition interventions through CHWs, and for monitoring and supervision by supervisors. Therefore, this application and job aid can be adopted or replicated into the currently developing national health systems platform for improving coverage and quality of preventive maternal and child nutrition services. In addition, continuous supportive supervision by skilled supervisors must be accompanied to ensure CHWs’ task quality. Finally, future studies should rigorously assess undesirable health and environmental effects of mHealth before and after mainstreaming, effective interventions addressing device-induced health hazards should be designed and scaled up, and effective e-waste management must be ensured. Full article

(This article belongs to the Section Nutrition and Public Health)

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41 pages, 1903 KiB

Open AccessReview

Acute Sarcopenia: Mechanisms and Management

by Sarah Damanti, Eleonora Senini, Rebecca De Lorenzo, Aurora Merolla, Simona Santoro, Costanza Festorazzi, Marco Messina, Giordano Vitali, Clara Sciorati and Patrizia Rovere-Querini

Nutrients 2024, 16(20), 3428; https://doi.org/10.3390/nu16203428 (registering DOI) - 10 Oct 2024

Abstract

Background: Acute sarcopenia refers to the swift decline in muscle function and mass following acute events such as illness, surgery, trauma, or burns that presents significant challenges in hospitalized older adults. Methods: narrative review to describe the mechanisms and management of acute sarcopenia. [...] Read more.

Background: Acute sarcopenia refers to the swift decline in muscle function and mass following acute events such as illness, surgery, trauma, or burns that presents significant challenges in hospitalized older adults. Methods: narrative review to describe the mechanisms and management of acute sarcopenia. Results: The prevalence of acute sarcopenia ranges from 28% to 69%, likely underdiagnosed due to the absence of muscle mass and function assessments in most clinical settings. Systemic inflammation, immune–endocrine dysregulation, and anabolic resistance are identified as key pathophysiological factors. Interventions include early mobilization, resistance exercise, neuromuscular electrical stimulation, and nutritional strategies such as protein supplementation, leucine, β-hydroxy-β-methyl-butyrate, omega-3 fatty acids, and creatine monohydrate. Pharmaceuticals show variable efficacy. Conclusions: Future research should prioritize serial monitoring of muscle parameters, identification of predictive biomarkers, and the involvement of multidisciplinary teams from hospital admission to address sarcopenia. Early and targeted interventions are crucial to improve outcomes and prevent long-term disability associated with acute sarcopenia. Full article

(This article belongs to the Special Issue Malnutrition, Acute Sarcopenia and Wasting Syndromes during Hospital Stay)

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22 pages, 796 KiB

Open AccessArticle

Developing Food Consumer Attitudes towards Ionizing Radiation and Genetic Modification

by Iwan Junaedi, Lisa S. McNeill and Robert P. Hamlin

Nutrients 2024, 16(20), 3427; https://doi.org/10.3390/nu16203427 (registering DOI) - 10 Oct 2024

Abstract

Background/Objectives: This study investigates consumer perceptions and acceptance of ionizing radiation (IoR) as a perishable food stabilisation technology. Consumers’ preferences influence the success of emerging food technologies. Therefore, a comprehensive understanding of consumers’ behavioural responses and their development over time is essential. Methods: [...] Read more.

Background/Objectives: This study investigates consumer perceptions and acceptance of ionizing radiation (IoR) as a perishable food stabilisation technology. Consumers’ preferences influence the success of emerging food technologies. Therefore, a comprehensive understanding of consumers’ behavioural responses and their development over time is essential. Methods: This research employs a mixed-methods approach, surveying 313 young adults in New Zealand on their views of both irradiated (IoR) and genetically modified (GM) highly perishable foods. This study explored both participants’ attitudes towards these two technologies and also their willingness to consume these foods. Results: The qualitative research revealed a preponderance of “affective” associations over “cognitive” associations with regard to both IoR and GM technologies. The quantitative research indicated that where consumers were given time to reflect, evaluations of GM improved, while those of IoR did not (p < 0.01). There was a gender divide, with females being more positively inclined towards GM and males towards IoR (p < 0.01). Both technologies were significantly disfavoured compared to non-treated products (p < 0.01). There was a significant discrimination when the two technologies were presented as concepts and as products. GM was more favourably received as a concept than as a product (p < 0.01), while IoR was disfavoured in either form. The two food neophobia scales that were tested showed a divergence in performance, with the more affectively based scale showing a higher level of correlation with behaviour. Conclusions: This research reveals that a largely affective (visceral) distrust of both IoR and GM exists within this young food consumer sample. As it is affective in nature, this position will be very resistant to education efforts, particularly if they are “cognitively” based. However, a significant softening of these affective attitudes towards GM products indicates that such efforts may be effective, given time and investment. Full article

(This article belongs to the Special Issue Food Nutrition Labels in Relation to Diet and Public Health (2nd Edition))

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17 pages, 2535 KiB

Open AccessArticle

Comparison of Dietary Supplementation with Krill Oil, Fish Oil, and Astaxanthin on an Experimental Ethanol-Induced Gastric Ulcer Model: A Biochemical and Histological Study

by Esra Tansu Sarıyer, Murat Baş, Hatice Çolak, Naziye Özkan Yenal, Özlem Unay Demirel and Meral Yüksel

Nutrients 2024, 16(20), 3426; https://doi.org/10.3390/nu16203426 (registering DOI) - 10 Oct 2024

Abstract

Background/Objectives: Despite advances in ulcer treatment research, the search for new, safe, and effective strategies for preventing and treating ulcer diseases persists. Methods: In this study, the protective effects of dietary supplementation with krill oil (KO), fish oil (FO), and astaxanthin (ASX) on [...] Read more.

Background/Objectives: Despite advances in ulcer treatment research, the search for new, safe, and effective strategies for preventing and treating ulcer diseases persists. Methods: In this study, the protective effects of dietary supplementation with krill oil (KO), fish oil (FO), and astaxanthin (ASX) on an ethanol-induced gastric ulcer model were compared during biochemical and histological observations. Sprague–Dawley (n = 64) rats randomly divided into four groups—normal control (vehicle), KO, FO, and ASX groups—received the supplements via the orogastric route at a rate of 2.5% (v/w) of their daily feed consumption for 4 weeks. Then, ulcer induction was performed with ethanol. Results: The ulcer group showed increased levels of malondialdehyde (MDA), chemiluminescence (CL), and myeloperoxidase (MPO) activity and decreased levels of glutathione in the gastric tissues. While KO, FO, and ASX supplementation decreased chemiluminescence levels in the ulcer group, only ASX supplementation decreased MDA levels and MPO activity. Conclusions: In conclusion, supplementation with KO or FO has a similar protective effect against ethanol-induced ulcer damage, as it inhibits ROS formation and reduces lipid peroxidation. However, ASX supplementation has a higher protective effect than KO or FO supplementations against experimental ethanol-induced gastric lesions in rats, as it inhibits ROS formation and reduces neutrophil infiltration and lipid peroxidation. Full article

(This article belongs to the Special Issue Nutritional Management in Gastrointestinal Diseases)

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Nutrients, Volume 16, Issue 20 (October-2 2024) – 9 articles

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