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Plant-Based Foods and Their Bioactive Components: Effects on Cardiometabolic Disorders and Related Molecular Mechanisms

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 3226

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Special Issue Editors

Dr. Ren-You Gan

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Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Singapore
Interests: phytochemicals; probiotics; prebiotics; gut microbiota; nutrition; functional food
Special Issues, Collections and Topics in MDPI journals

Dr. Hongyan Liu

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Guest Editor

Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, National Agricultural Science and Technology Center, Chengdu 610213, China
Interests: food authentication; polyphenol; MS-based metabolomics; functional food; chemometrics
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Prof. Dr. Liang Zeng

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College of Food Science, Southwest University, Chongqing, China
Interests: nutritional and functional effect of tea and natural products; development of tea products (preliminary processing, deep processing); evaluation of tea flavor quality characteristics

Prof. Dr. Dingtao Wu

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Guest Editor

Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Province Engineering Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
Interests: dietary fiber; structural characterization; chemical modification; quality evaluation; metabolic disorders; gut microbiota
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Dr. Danyue Zhao

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Guest Editor

Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong 999077, China
Interests: polyphenol; phytochemical; functional gut bacteria; probiotics; phytochemical–gut microbiota interaction; metabolic disease; mass spectrometry-based metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiometabolic disorders, such as metabolic syndrome, cardiovascular diseases, diabetes, obesity, non-alcoholic fatty liver disease, and certain types of cancers, are a significant global health concern, which require multi-faceted management approaches, such as individual lifestyle and dietary changes as well as innovative prevention and treatment strategies.

Plant-based foods, such as fruit, vegetables, whole grains, legumes, nuts, spices, wine, and certain functional plants, contain numerous bioactive components such as phytochemicals (e.g., polyphenols), vitamins, polysaccharides, dietary fibers, and bioactive peptides, which have been demonstrated to exhibit versatile bioactivities such as antioxidant, anti-inflammatory, hypotensive, hypoglycemic, hypolipidemic, anti-obesity, anti-diabetic, and anti-cancer properties. It is essential to prompt research on the potential roles of plant-based foods and their bioactive components in the prevention and treatment of cardiometabolic disorders.

The molecular mechanisms underlying the effects of plant-based foods and their bioactive components on cardiometabolic disorders are complex and multifaceted, involving metabolic pathway modulation, gene expression regulation, oxidative stress and inflammation inhibition, insulin sensitivity improvement, and gut microbiota modulation, among others.

This Special Issue welcomes authors to submit original research articles or reviews addressing the health impacts of plant-based foods and their bioactive components on cardiometabolic disorders. Potential topics include, but are not limited to, the following:

Antioxidant and anti-inflammatory properties of plant-based foods and their bioactive components;
Effects and underlying mechanisms of plant-based food bioactive components on glucose metabolism, lipid metabolism, insulin sensitivity, and cancer cells;
Health impacts of plant-based foods and their bioactive components on body weight regulation and obesity management;
Synergistic effects of plant-based foods in the management of cardiometabolic disorders;
The interaction of plant-based foods or their bioactive components with the gut microbiome and related health impacts on cardiometabolic disorders;
Clinical trials evaluating the cardiometabolic benefits of plant-based foods or their bioactive components.

Dr. Ren-You Gan
Dr. Hongyan Liu
Prof. Dr. Liang Zeng
Prof. Dr. Dingtao Wu
Dr. Danyue Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

fruit and vegetables
grains and legumes
dietary bioactive compounds
phytochemicals
flavonoids
polysaccharides
cardiometabolic disorders
cancer
gut microbiome

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Research

18 pages, 3163 KiB

Open AccessArticle

Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies

by Mihai Babotă, Oleg Frumuzachi, Corneliu Tanase and Andrei Mocan

Nutrients 2024, 16(21), 3730; https://doi.org/10.3390/nu16213730 - 31 Oct 2024

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Abstract

Background/Objectives: Type 2 diabetes mellitus (T2DM) is a disorder characterized by insulin resistance, hyperglycemia, and dyslipidemia. Myricetin, a flavonoid found in various plants, has shown potential anti-diabetic effects in murine studies. This meta-analysis aimed to evaluate the impact of myricetin supplementation on glucose metabolism and lipid profiles in mouse models of metabolic diseases. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines (PROSPERO: CRD42024591569). Studies involving mice with metabolic disease models and exclusively using myricetin supplementation were checked across four databases (Embase, Scopus, PubMed, and WoS) until 23rd September 2024. The primary outcomes assessed were blood glucose (BG), insulin levels, triacylglycerol (TAG), total cholesterol (TC), HDL, and LDL. A random-effects model was applied to estimate standardized mean differences (SMD), and SYRCLE’s risk-of-bias tool for animal studies was used. Results: Twenty-one studies with 514 mice met the inclusion criteria. Myricetin supplementation significantly reduced BG (SMD = −1.45, CI: −1.91 to −0.99, p < 0.00001, I² = 74%), insulin (SMD = −1.78, CI: −2.89 to −0.68, p = 0.002, I² = 86%), TAG (SMD = −2.60, CI: −3.24 to −1.96, p < 0.00001, I² = 81%), TC (SMD = −1.86, CI: −2.29 to −1.44, p < 0.00001, I² = 62%), and LDL (SMD = −2.95, CI: −3.75 to −2.14, p < 0.00001, I² = 74%). However, the effect on HDL was not statistically significant (SMD = 0.71, CI: −0.01 to 1.43, p = 0.05, I² = 83%). Conclusions: Myricetin supplementation improved glucose metabolism and lipid profiles in mouse models, suggesting its potential as a therapeutic agent for managing T2DM. However, further research is needed to confirm these findings in human studies. Full article

(This article belongs to the Special Issue Plant-Based Foods and Their Bioactive Components: Effects on Cardiometabolic Disorders and Related Molecular Mechanisms)

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16 pages, 4181 KiB

Open AccessArticle

Discovery of Curcuminoids as Pancreatic Lipase Inhibitors from Medicine-and-Food Homology Plants

by Xiao-Qin He, Hai-Dan Zou, Yi Liu, Xue-Jiao Chen, Atanas G. Atanasov, Xiao-Li Wang, Yu Xia, Siew Bee Ng, Maima Matin, Ding-Tao Wu, Hong-Yan Liu and Ren-You Gan

Nutrients 2024, 16(15), 2566; https://doi.org/10.3390/nu16152566 - 5 Aug 2024

Cited by 1 | Viewed by 1744

Abstract

Researchers are increasingly interested in discovering new pancreatic lipase inhibitors as anti-obesity ingredients. Medicine-and-food homology plants contain a diverse set of natural bioactive compounds with promising development potential. This study screened and identified potent pancreatic lipase inhibitors from 20 commonly consumed medicine-and-food homology plants using affinity ultrafiltration combined with spectroscopy and docking simulations. The results showed that turmeric exhibited the highest pancreatic lipase-inhibitory activity, and curcumin, demethoxycurcumin, and bisdemethoxycurcumin were discovered to be potent pancreatic lipase inhibitors within the turmeric extract, with IC₅₀ values of 0.52 ± 0.04, 1.12 ± 0.05, and 3.30 ± 0.08 mg/mL, respectively. In addition, the enzymatic kinetics analyses demonstrated that the inhibition type of the three curcuminoids was the reversible competitive model, and curcumin exhibited a higher binding affinity and greater impact on the secondary structure of pancreatic lipase than found with demethoxycurcumin or bisdemethoxycurcumin, as observed through fluorescence spectroscopy and circular dichroism. Furthermore, docking simulations supported the above experimental findings, and revealed that the three curcuminoids might interact with amino acid residues in the binding pocket of pancreatic lipase through non-covalent actions, such as hydrogen bonding and π-π stacking, thereby inhibiting the pancreatic lipase. Collectively, these findings suggest that the bioactive compounds of turmeric, in particular curcumin, can be promising dietary pancreatic lipase inhibitors for the prevention and management of obesity. Full article

(This article belongs to the Special Issue Plant-Based Foods and Their Bioactive Components: Effects on Cardiometabolic Disorders and Related Molecular Mechanisms)

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Plant-Based Foods and Their Bioactive Components: Effects on Cardiometabolic Disorders and Related Molecular Mechanisms

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