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New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 9830

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
Interests: phitochemicals; bioactive peptides; bioactive compounds characterization; antihypertensive activity; molecular biology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Univer-sitat Rovira i Virgili, 43007 Tarragona, Spain
Interests: phitochemicals; bioactive peptides; bioactive compounds characterization; antihypertensive activity; molecular biology

E-Mail Website
Guest Editor
Departmental Section of Galenic Pharmacy and Food Technology, Veterinary Faculty, Complutense University of Madrid, 28040 Madrid, Spain
Interests: bioactive compounds; supercritical fluids; bioactivities; HPLC; food; volatile component
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome is characterized by the coexistence of different diseases including hypertension, obesity, insulin resistance and atherogenic dyslipidemia. It has a high prevalence in our society, as it is suffered up to 25 % of adults and 19.2 % of children. However, the treatment of metabolic syndrome and its associated pathologies is still a medical challenge, considering the complexity of this multifactorial disease. Therefore, new compounds are searched in order to prevent or reduce this cluster of diseases. In this regard, food and agri-food by-products contain different compounds such as phenolic compounds, fatty acids or peptides with antihypertensive, anti-hyperglycemic, anti-hypercholesterolemic, antioxidant and anti-inflammatory effects and also they can produce body weight loss or prevent against body weight gain. Thus, these compounds are highly studied in the search of metabolic syndrome treatments.

The aim of this special issue is to collect original research manuscripts, meta-analysis and reviews dealing with the beneficial effect of bioactive compounds on metabolic syndrome and its associated diseases. We invite clinicians and researchers to submit relevant scientific work to this Special Issue. Original research manuscripts, both using human and animal models, focused on the search and evaluation of the functional properties of original or known products, extracts, and single molecules from plants, food and agri-food by-products, as well as diets will be considered. Moreover, the in vitro or in vivo studies to elucidate the involved mechanisms in the effects of different bioactive compounds will be also welcomed.

Dr. Francisca Bravo
Dr. Enrique Calvo Manso
Dr. Diego Morales
Guest Editors

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Keywords

  • antihyperglycemic
  • antihypertensive
  • antioxidants
  • bioactive peptides
  • cardiovascular diseases
  • hyper-tension
  • obesity
  • phenolic compounds
  • phytochemicals

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Published Papers (3 papers)

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Research

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14 pages, 2147 KiB  
Article
Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study
by Blanca Riquelme-Gallego, Laura García-Molina, Naomi Cano-Ibáñez, Francisco Andújar-Vera, Sheila González-Salvatierra, Cristina García-Fontana, Aurora Bueno-Cavanillas, Manuel Muñoz-Torres and Beatriz García-Fontana
Nutrients 2022, 14(14), 2991; https://doi.org/10.3390/nu14142991 - 21 Jul 2022
Cited by 4 | Viewed by 2402
Abstract
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) [...] Read more.
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone metabolism have been associated with CVR. The aim of this study was to determine the levels of undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was conducted in which a MetS population was followed for one year. Weight change, adherence to the Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was calculated using different scores. Our results showed a decrease of CVR associated with a better adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels could be good predictors of T2D prevalence. Full article
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Review

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24 pages, 426 KiB  
Review
Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides
by Francisca Isabel Bravo, Enrique Calvo, Rafael A. López-Villalba, Cristina Torres-Fuentes, Begoña Muguerza, Almudena García-Ruiz and Diego Morales
Nutrients 2023, 15(2), 457; https://doi.org/10.3390/nu15020457 - 15 Jan 2023
Cited by 12 | Viewed by 3585
Abstract
Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of [...] Read more.
Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses. Full article
17 pages, 374 KiB  
Review
Potential Role of Bioactive Proteins and Peptides Derived from Legumes towards Metabolic Syndrome
by Marta Garcés-Rimón, Diego Morales and Marta Miguel-Castro
Nutrients 2022, 14(24), 5271; https://doi.org/10.3390/nu14245271 - 10 Dec 2022
Cited by 10 | Viewed by 3010
Abstract
Legumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible [...] Read more.
Legumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible chronic diseases, specifically metabolic syndrome. An exhaustive revision of five relevant bioactivities (antioxidant, anti-inflammatory, antihypertensive, hypocholesterolemic -all of them linked to metabolic syndrome- and antitumoral) of proteins and peptides from legumes focused on isolation and purification, enzymatic hydrolysis and in vitro gastrointestinal digestion was carried out. The promising potential of bioactive hydrolysates and peptides from pulses has been demonstrated by in vitro tests. However, only a few studies validated these biological activities using animal models. No clinical trials have been carried out yet; so further research is required to elucidate their effective health implications. Full article
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