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Nutrients
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Exercise, Diet and Type 2 Diabetes
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Exercise, Diet and Type 2 Diabetes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: 25 February 2025 | Viewed by 321

Special Issue Editor

Dr. Noriyuki Kitagawa

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Guest Editor
1. Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
2. Department of Diabetology, Kameoka Municipal Hospital, Kameoka 621-8585, Japan
Interests: nutrient; diabetes; immune metabolism; exercise in diabetes; slowly progressive insulin-dependent diabetes mellitus
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are setting a Special Issue in Nutrients dedicated to the interaction of exercise and type 2 diabetes on skeletal muscle. The loss of skeletal muscle mass or locomotor function is associated with insulin resistance and/or chronic inflammation, which induce several diseases such as type 2 diabetes and cardiovascular disease. Although several exercise therapy approaches, with or without diet manipulation, could prevent or reduce the progression towards type 2 diabetes, the ideal exercise therapy has not been fully elucidated. Therefore, new innovation is needed to establish the ideal exercise approach. This Special Issue welcomes original research articles or clinical trials highlighting new biomarkers or development of therapeutic agents targeting skeletal muscle following exercise with or without diet manipulations in type 2 diabetes or related obesity metabolic disorders We look forward to your submissions.

Dr. Noriyuki Kitagawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exercise
  • diet
  • type 2 diabetes
  • skeletal muscle mass
  • sarcopenia

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Published Papers (1 paper)

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Research

12 pages, 2791 KiB  
Article
Daidzein Inhibits Muscle Atrophy by Suppressing Inflammatory Cytokine- and Muscle Atrophy-Related Gene Expression
by Chihiro Munekawa, Takuro Okamura, Saori Majima, Budau River, Sayaka Kawai, Ayaka Kobayashi, Hanako Nakajima, Nobuko Kitagawa, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi and Michiaki Fukui
Nutrients 2024, 16(18), 3084; https://doi.org/10.3390/nu16183084 - 13 Sep 2024
Viewed by 247
Abstract
Background: Sarcopenic obesity, which is associated with a poorer prognosis than that of sarcopenia alone, may be positively affected by soy isoflavones, known inhibitors of muscle atrophy. Herein, we hypothesize that these compounds may prevent sarcopenic obesity by upregulating the gut metabolites with [...] Read more.
Background: Sarcopenic obesity, which is associated with a poorer prognosis than that of sarcopenia alone, may be positively affected by soy isoflavones, known inhibitors of muscle atrophy. Herein, we hypothesize that these compounds may prevent sarcopenic obesity by upregulating the gut metabolites with anti-inflammatory effects. Methods: To explore the effects of soy isoflavones on sarcopenic obesity and its mechanisms, we employed both in vivo and in vitro experiments. Mice were fed a high-fat, high-sucrose diet with or without soy isoflavone supplementation. Additionally, the mouse C2C12 myotube cells were treated with palmitic acid and daidzein in vitro. Results: The isoflavone considerably reduced muscle atrophy and the expression of the muscle atrophy genes in the treated group compared to the control group (Fbxo32, p = 0.0012; Trim63, p < 0.0001; Foxo1, p < 0.0001; Tnfa, p = 0.1343). Elevated levels of daidzein were found in the muscles and feces of the experimental group compared to the control group (feces, p = 0.0122; muscle, p = 0.0020). The real-time PCR results demonstrated that the daidzein decreased the expression of the palmitate-induced inflammation and muscle atrophy genes in the C2C12 myotube cells (Tnfa, p = 0.0201; Il6, p = 0.0008; Fbxo32, p < 0.0001; Hdac4, p = 0.0002; Trim63, p = 0.0114; Foxo1, p < 0.0001). Additionally, it reduced the palmitate-induced protein expression related to the muscle atrophy in the C2C12 myotube cells (Foxo1, p = 0.0078; MuRF1, p = 0.0119). Conclusions: The daidzein suppressed inflammatory cytokine- and muscle atrophy-related gene expression in the C2C12 myotubes, thereby inhibiting muscle atrophy. Full article
(This article belongs to the Special Issue Exercise, Diet and Type 2 Diabetes)
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