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High Fat Diet and Hepatic Steatosis

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 1444

Special Issue Editor


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Guest Editor
Department of Medicine and Surgery, University of Perugia, via L. Severi 1, 06132 Perugia, Italy
Interests: metabolic disease; bile acids; bile acids receptors; inflammation; innate and adaptive immune system, intestinal microbiota

Special Issue Information

Dear Colleagues,

Nonalcoholic Fatty Liver Disease (NAFLD) is a common hepatic disorder affecting approximately one quarter of the world’s population caused by an excessive accumulation of lipids in hepatocytes, and representing a rapidly growing healthcare problem. NAFLD is categorized histologically into non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). In the last two decades, NAFLD has become the leading cause of liver disease on a global scale becoming the main determinant of liver-related mortality.

The increase in the incidence of NASH over the past 10–15 years, coupled with the absence of approved drugs for the treatment of NASH, has made this disease an attractive field of research in fact several candidate drugs have been advanced to Phase II and III.

Dr. Michele Biagioli
Guest Editor

Manuscript Submission Information

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Keywords

  • lipid metabolism
  • inflammation
  • Non-Alcoholic Fatty Liver Disease (NAFLD)
  • Non-Alcoholic steatohepatitis
  • cardiovascular diseases
  • microbiota

Published Papers (1 paper)

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Research

14 pages, 2210 KiB  
Article
Food Network Analysis in Non-Obese Patients with or without Steatosis
by Rossella Donghia, Pasqua Letizia Pesole, Sergio Coletta, Caterina Bonfiglio, Giovanni De Pergola, Sara De Nucci, Roberta Rinaldi and Gianluigi Giannelli
Nutrients 2023, 15(12), 2713; https://doi.org/10.3390/nu15122713 - 11 Jun 2023
Cited by 2 | Viewed by 1081
Abstract
Background: Steatosis is the most common liver disease worldwide and the leading cause of liver-associated morbidity and mortality. The aim of this study was to explore the differences in blood parameters and dietary habits in non-obese patients with and without steatosis. Methods: The [...] Read more.
Background: Steatosis is the most common liver disease worldwide and the leading cause of liver-associated morbidity and mortality. The aim of this study was to explore the differences in blood parameters and dietary habits in non-obese patients with and without steatosis. Methods: The present study included 987 participants with BMI < 30, assessed in the fourth recall of the MICOL study. Patients were divided by steatosis grade, and a validated food frequency questionnaire (FFQ) with 28 food groups was administered. Results: The prevalence of non-obese participants with steatosis was 42.86%. Overall, the results indicated many statistically significant blood parameters and dietary habits. Analysis of dietary habits revealed that non-obese people with or without steatosis had similar dietary habits, although higher daily amounts of red meat, processed meat, ready meals, and alcohol were recorded in participants with liver disease (p < 0.05). Conclusions: Many differences were found in non-obese people with and without steatosis, but in light of a network analysis, the two groups demonstrated similar dietary habits, proving that pathophysiological, genetic, and hormonal patterns are probably the basis of their liver status, regardless of weight. Future genetic analyses will be performed to analyze the expression of genes involved in the development of steatosis in our cohort. Full article
(This article belongs to the Special Issue High Fat Diet and Hepatic Steatosis)
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